If you like harnessing carbenes from di-chlorides, you’ll LOVE skeletal editing with tri-chlorides! Congrats to Bethany, Hojin, Victoria, and our collaborators from Chicago (Ethan & Mark Levin) and California (Anna, Zhang & Dave Olson)! Open access: authors.elsevier.com/a/1mqdE8jWHE...

There's no better validation of a synthetic method than success in other chemists' hands!! Many thanks! 🙏

Scott Bagley@bagphos.bsky.social · 7mo ago

Wonderful deutero carbene cyclopropanation work here from the @nagiblab.bsky.social on #OrgLettASAP Super easy to set up So much better than other routes Just came out this week and I’ve already made compounds with this reaction - if I can do it…anyone can! #ChemSky

Wonderful deutero carbene cyclopropanation work here from the @nagiblab.bsky.social on #OrgLettASAP Super easy to set up So much better than other routes Just came out this week and I’ve already made compounds with this reaction - if I can do it…anyone can! #ChemSky

Deuterated Cyclopropanation of Alkenes by Iron Catalysis

Deuterium labeling is a key tool used in drug development to observe and prevent metabolism. Here, we report a mild and operationally simple protocol for the synthesis of deuterated cyclopropanes with high levels of deuterium incorporation. This Fe-catalyzed strategy uses dichloromethane-d2 for safe, practical, and diazo-free access to carbene reactivity. A sterically and electronically diverse range of alkenes with varying functional groups are tolerated in this deuterated cyclopropanation. This highly air and water tolerant method complements existing strategies and significantly broadens access to valuable deuterated cyclopropanes, including with applications for the late-stage functionalization of pharmaceuticals.

doi.org

THE Organic Chemistry Buckeye Tailgate! 👀 Sevov Zhang Raps Thomas Labs

In @science.org this week, THE @nagiblab.bsky.social makes all the carbenes (no, seriously!) and classifies their electronic properties on a common basis chemsky 🧪 www.science.org/doi/10.1126/...

Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes

Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all ...

science.org

After a decade of obssession by our lab, Pavitra & Ipshita developed an enantioselective Hofmann-Loffler-Freytag reaction! If you haven't had a chance to read about our chiral pyrrolidine story … Open access link expires tomorrow: authors.elsevier.com/a/1jxh-9URZ7... 1st #chemsky