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Narayanan Lab

@narayananlab.bsky.social

Systems neuroscientist & Parkinson's neurologist. We map brain circuits of higher-order thought. @UIowaNeuro @IowaNeurology

53 Posts184 Follower35 Folgt
Narayanan Lab@narayananlab.bsky.social · 4mo ago

pubmed.ncbi.nlm.nih.gov/41966430/ congrats to the Aldridge lab on getting this important methods paper out!

Renovating the Barnes maze for mouse models of dementia with STARR FIELD: A 4-day protocol for learning rate, retention, and cognitive flexibility - PubMed

Land-based spatial mazes are a low-stress method to evaluate learning in rodent models of dementia. By using innate exploratory and hiding behavior, the Barnes maze requires fewer trials, allowing exa...

pubmed.ncbi.nlm.nih.gov

Narayanan Lab@narayananlab.bsky.social · 4mo ago

I've been quiet on social media recently - but I miss the opportunity to talk about all the cool things happening with other scientists since the days of Twitter. So - congrats to Hannah Stutt on defending her PhD on dorsal striatal dopamine and timing. Next step: on to awesome postdoctoral work!

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Narayanan Lab@narayananlab.bsky.social · last yr.

Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : www.medrxiv.org/content/10.1...

Linear predictive coding electroencephalography algorithms predict Parkinson's disease mortality using out-of-sample tests

Background: Parkinson's disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives: We used el...

medrxiv.org

Narayanan Lab@narayananlab.bsky.social · last yr.

Our latest work: www.biorxiv.org/content/10.1... We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.

Timing, movement, and reward contributions to prefrontal and striatal ramping activity

Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if ra...

biorxiv.org

Narayanan Lab@narayananlab.bsky.social · 2y ago

Very happy that our paper describing a new D1 FLP mouse is up: pubmed.ncbi.nlm.nih.gov/39701542/ Youngcho Kim's first paper as corresponding author! Some brief backstory (1/5)

Generation and validation of a D1 dopamine receptor Flpo knock-in mouse - PubMed

We demonstrated brain-wide GFP expression driven by Drd1-Flpo, suggesting that this mouse line may be useful for comprehensive anatomical and functional studies in many brain regions. The Drd1-Flpo mo...

pubmed.ncbi.nlm.nih.gov

Narayanan Lab@narayananlab.bsky.social · 2y ago

All this pressure from all these new followers! Luckily, we have a new preprint: pubmed.ncbi.nlm.nih.gov/39569181/

Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories - PubMed

Generalizing aversive memories helps organisms avoid danger, whereas discriminating between dissimilar situations promotes opportunistic behaviors. We identified a novel pathway that controls the cont...

pubmed.ncbi.nlm.nih.gov

Narayanan Lab@narayananlab.bsky.social · 2y ago

Wild - the term 'prefrontal' I think first appeared in 1878 in the journal Brain relating Phineas Gage and other lesions. For the human chauvinists out there - I think the term originates from fish skull anatomy, and in the first description - animal references abound:

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