Our recent review on i-motifs reflects on our current insights on i-motifs and methodological challenges! #DNA

Department of Medical Biochemistry and Biophysics (MBB)@mbb-umu.bsky.social · 4mo ago

New review out in Genome Biology by Dr. Sengupta & @nasimsabouri.bsky.social on i-motifs—four-stranded DNA structures with emerging roles in gene regulation. 👉 rdcu.be/feK1J #GenomeBiology #DNA #Research #UmeåUniversity

We carried out a mechanistic study on how the PCBP1 protein destabilizes i-motifs. Understanding these interactions helps clarify fundamental mechanisms that control genome function. Grateful for the long-term support we have received! @kawresearch.bsky.social @mbb-umu.bsky.social rdcu.be/e2pIv

Mechanistic insights into PCBP1-driven unfolding of selected i-motif DNA at G1/S checkpoint

Nature Communications - I-motifs are non-canonical secondary DNA structures that form dynamically in certain C-rich DNA regions. Here, the authors show that PCBP1 binds and unfolds i-motifs in a...

rdcu.be

Knut and Alice Wallenberg Foundation@kawresearch.bsky.social · 6mo ago

Researchers have shown that i-DNA, not only forms in living cells but also acts as a regulatory bottleneck linked to cancer @nasimsabouri.bsky.social @umeauniversitet.bsky.social #research supported by Knut and Alice Wallenberg Foundation tinyurl.com/45rdhz9s To the study tinyurl.com/2eybhhc9

CRISPR-Cas9 targeting of G-Quadruplex DNA in ADH1 promoter highlights its role in transcriptome and metabolome regulation url: academic.oup.com/nar/article/... Grateful for all the hard work from my team. #yeast #quadruplex #metabolomics

Big milestone from our team! Congrats to all! Photodynamic Therapy Using a Heavy-Atom-Free G-Quadruplex-Targeted Photosensitizer to Efficiently Regress Rhabdomyosarcoma Tumors In Vivo pubs.acs.org/doi/10.1021/... #quadruplex #G4 #DNA #cancer #zebrafish

Our newest preprint demonstrates that a single G-quadruplex (G4) DNA structure can significantly impact yeast metabolism. www.biorxiv.org/content/10.1...

CRISPR-Cas9 Targeting of G-Quadruplex DNA in ADH1 promoter Highlights its role in Transcriptome and Metabolome Regulation

G-quadruplex (G4) structures are critical regulators of gene expression, yet the role of an individual G4 within its native chromatin remains underexplored. Here, we used CRISPR-Cas9 to introduce guan...

biorxiv.org

We have a postdoctoral position opening in my lab at Umeå University. Please share! More info about the position and how to apply: //www.nature.com/naturecareers/job/12838556/postdoctoral-fellowship-in-molecular-biology-with-focus-on-quadruplex-dna-structures

Postdoctoral fellowship in Molecular Biology with focus on Quadruplex DNA structures - Umeå, Sweden job with Umeå University | 12838556

The Department of Medical Biochemistry and Biophysics at Umeå University, Sweden, invites applicants for a two-year Postdoctoral fellowship.

nature.com

The deadline is approaching fast for our postdoc position in Quadruplex DNA structures at Umeå University. Make sure to apply before February 28th! #sciencecareers #postdoc #DNA

Nasim Sabouri@nasimsabouri.bsky.social · 2y ago

🚨 On the market for an exciting Postdoctoral position? 🧬We are passionate about Quadruplex DNA structures and just have an opening in my lab at Umeå University 🗓 Deadline Feb 28th Please share 👇 More info www.nature.com/naturecareer...

It was a beautiful, peaceful morning and a magical evening on the very first day of the year. Let’s welcome 2025 with hope and endless possibilities! Wishing you all a Happy New Year! ✨

🚨 On the market for an exciting Postdoctoral position? 🧬We are passionate about Quadruplex DNA structures and just have an opening in my lab at Umeå University 🗓 Deadline Feb 28th Please share 👇 More info www.nature.com/naturecareer...

🚨 JOB OPENING 🚨 We are seeking a new Chief Editor for @naturesynthesis.bsky.social 🧪 📍 Beijing, New York or Shanghai 🗓️ Closing date: Dec 31, 2024 ✉️ DMs open for questions 🙏 Re-posts very much appreciated! springernature.wd3.myworkdayjobs.com/SpringerNatu... #Chemsky #Editorial #Publishing

a cartoon of two bears applying to jobs

Alt: A cartoon of a panda typing on a computer with a brown bear pacing in the background. At the top it says 'applying to jobs'.

media.tenor.com

Join Umeå University as Assistant Professor and benefit from an amazing start-up package and state-of-the-art facilities to jumpstart your next step in your academic career. Please share this post. www.umu.se/en/work-with...

Up to three positions as assistant professor (tenure track, group leader) in molecular medicine at Wallenberg Centre for Molecular Medicine

umu.se

Given the growth of this forum in the last couple of weeks, I'm reposting our open PhD position. Come do a PhD on virus replication using our world-class, in-house cryo-EM facility. Dynamic and friendly infection biology community. Deadline in <2 weeks!

Lars-Anders Carlson@lacarlson.bsky.social · 2y ago

Repost appreciated: Open #PhDposition in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET with great #virology and #biophysics collaborators. Customisable project. Application deadline 15 December. More info: www.carlsonlab.se/join/

We are now on board 👍 @valwood.bsky.social