Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice

Nature Biomedical Engineering, Published online: 05 August 2026; doi:10.1038/s41551-026-01765-wEngineered lipid nanoparticles enable CD34-targeted delivery and in vivo editing of haematopoietic stem and progenitor cells while preserving haematopoiesis.

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XunZi, an AI biologist, reveals disease-modifying targets

Nature Biomedical Engineering, Published online: 04 August 2026; doi:10.1038/s41551-026-01769-6XunZi is an AI biologist capable of synergizing logical reasoning and multimodal data fusion to generate de novo therapeutic target hypotheses. XunZi was used to discover two therapeutic targets in Parkinson’s disease that were subsequently verified.

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EU’s fragmented early-stage medical device study requirements need reform

Nature Biomedical Engineering, Published online: 31 July 2026; doi:10.1038/s41551-026-01750-3Legislative change must fix the European Union’s disharmonized map of early-stage medical device clinical study requirements, whereby fragmented interpretations across Member States create barriers to innovation and delay patient access to life-saving technologies.

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Rebalancing bone remodelling in osteoporosis

Nature Biomedical Engineering, Published online: 30 July 2026; doi:10.1038/s41551-026-01702-xA structurally engineered sulfated polysaccharide rebalances bone homeostasis by limiting bone resorption without depleting regenerative cell populations.

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Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis

Nature Biomedical Engineering, Published online: 30 July 2026; doi:10.1038/s41551-026-01744-1A synthetic polysaccharide modulates cell signalling to arrest preosteoclast fusion and drive mineralization, balancing bone resorption and formation in the treatment of osteoporosis.

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European Union innovation needs regulatory science excellence centres

Nature Biomedical Engineering, Published online: 29 July 2026; doi:10.1038/s41551-026-01756-xFit-for-purpose regulation of medical devices and medical artificial intelligence in Europe needs Centres of Excellence in Regulatory Science and Innovation, providing research on concepts, early evidence generation, and horizon scanning on emerging needs and technologies.

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In vivo CRISPR base editing for treatment of Huntington’s disease

Nature Biomedical Engineering, Published online: 29 July 2026; doi:10.1038/s41551-026-01747-yCRISPR base editors were used to create proteolysis-resistant huntingtin isoforms to reduce the production of aggregation-prone protein fragments that contribute to neurotoxicity and to mitigate toxicity in mouse models of Huntington’s disease.

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Sequencing-free spatial profiling of post-transcriptional regulation in fresh tissues using nanoneedle arrays

Nature Biomedical Engineering, Published online: 28 July 2026; doi:10.1038/s41551-026-01745-0A sequencing-free and amplification-free approach for the spatial profiling of post-transcriptional regulation across large tissue sections maps RNA regulation in developing mouse neural tissue and the olfactory bulb.

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Atmospheric water harvesting for humidity control in medical devices for global health

Nature Biomedical Engineering, Published online: 27 July 2026; doi:10.1038/s41551-026-01751-2This Perspective examines how atmospheric water harvesting can be repurposed to manage moisture in biomedical devices, enabling hydration buffering, sample generation and improved performance.

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A PET reporter ligand for quantitative imaging of gene expression in the brain

Nature Biomedical Engineering, Published online: 27 July 2026; doi:10.1038/s41551-026-01748-xA small-molecule fluorine-18 HaloTag ligand optimized for entry into the brain and covalent retention at the reporter provides a tool for non-invasive positron emission tomography quantification of gene expression in mouse models.

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Pathology-CoT: learning visual chain-of-thought agents from expert whole-slide image diagnosis behaviour

Nature Biomedical Engineering, Published online: 24 July 2026; doi:10.1038/s41551-026-01739-yPathology-CoT converts routine viewing logs into task-conditioned behavioural supervision paired with expert-verified reasoning, supplying the supervision required for the development of Pathology-o3, a human-aligned agent for digital pathology.

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Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart

Nature Biomedical Engineering, Published online: 24 July 2026; doi:10.1038/s41551-026-01755-yA submillimetre in vivo cardiac diffusion tensor imaging method enables voxel-scale phenomapping of myocardial microstructure and shows preserved microstructural classes in the pressure-overloaded human heart.

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CLEAR: an auditable foundation model for radiology grounded in clinical concepts

Nature Biomedical Engineering, Published online: 22 July 2026; doi:10.1038/s41551-026-01741-4CLEAR is an auditable foundation model for chest X-rays that leverages the collective knowledge of the radiological community to offer improved interpretability, performance and new applications.

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Super homotypic targeting by surface engineering of extracellular vesicles

Nature Biomedical Engineering, Published online: 22 July 2026; doi:10.1038/s41551-026-01743-2Engineering the surface of small extracellular vesicles with lanthanide ions enhances homotypic targeting of cells through competitive coordination with sialic acid residues overexpressed on cancer cell surfaces, allowing the detection of cancer cell-derived small extracellular vesicles and circulating tumour cells.

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Nanosensor-integrated catheters for chemical mapping of bladder cancer biomarkers

Nature Biomedical Engineering, Published online: 17 July 2026; doi:10.1038/s41551-026-01763-yNanosensor-integrated catheters for chemical mapping of bladder cancer biomarkers

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Design with women in mind

Nature Biomedical Engineering, Published online: 17 July 2026; doi:10.1038/s41551-026-01758-9Biomedical engineers are poised to meet urgent unmet needs in women’s health. We share our excitement about research in women’s health and our plans to champion such advances in our pages.

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RModBlock antisense oligonucleotides as a universal tool for precise and efficient inhibition of RNA modifications

Nature Biomedical Engineering, Published online: 16 July 2026; doi:10.1038/s41551-026-01746-zA strategy using chemically modified antisense oligonucleotides with locked nucleic acid shows broad applicability for inhibiting RNA modifications by blocking the formation of required structural conformations.

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AI meets high-throughput screening of LNPs

Nature Biomedical Engineering, Published online: 15 July 2026; doi:10.1038/s41551-026-01737-0Two studies highlight the ways in which artificial intelligence can be used to improve ionizable lipid design for lipid nanoparticle-mediated mRNA delivery.

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Small language models in medicine

Nature Biomedical Engineering, Published online: 13 July 2026; doi:10.1038/s41551-026-01734-3Small language models can serve as a more scalable, practical and efficient alternative for medical applications compared to large language models. Here we discuss the strengths and limitations, challenges and future directions of small language models in healthcare implementation, highlighting their potential to enable broader real-world adoption across diverse clinical settings.

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Large-scale multi-sequence pretraining for generalizable MRI analysis in versatile clinical applications

Nature Biomedical Engineering, Published online: 13 July 2026; doi:10.1038/s41551-026-01740-5A foundation model for magnetic resonance imaging (MRI) with large-scale multi-sequence pretraining, MARS, overcomes limitations in image heterogeneity to enable versatile real-world multi-sequence MRI analysis on diverse anatomical structures.

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Neuro-symbolic artificial intelligence in medicine

Nature Biomedical Engineering, Published online: 10 July 2026; doi:10.1038/s41551-026-01728-1Neuro-symbolic approaches may address long-standing limitations in biomedical artificial intelligence by integrating data-driven inference with explicit clinical knowledge to improve safety, transparency and accountability.

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Author Correction: Towards clinical-level interpretation of dental panoramic radiography using an instance-guided vision-language model

Nature Biomedical Engineering, Published online: 08 July 2026; doi:10.1038/s41551-026-01759-8Author Correction: Towards clinical-level interpretation of dental panoramic radiography using an instance-guided vision-language model

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Real-time single-particle imaging of functional lungs reveals mosaic-like patterns of aerosol deposition in alveoli

Nature Biomedical Engineering, Published online: 08 July 2026; doi:10.1038/s41551-026-01724-5Real-time single-particle imaging of whole lungs reveals deterministic, mosaic-like aerosol deposition that is conserved across species, shaped by lung architecture and disrupted in models of emphysema, fibrosis and metastasis.

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Author Correction: Rewiring oncogenic signalling to precision ablation of metastatic cancer

Nature Biomedical Engineering, Published online: 07 July 2026; doi:10.1038/s41551-026-01753-0Author Correction: Rewiring oncogenic signalling to precision ablation of metastatic cancer

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Engineering bispecific antibodies for brain delivery of biotherapeutics in multiple species

Nature Biomedical Engineering, Published online: 07 July 2026; doi:10.1038/s41551-026-01717-4Using active learning-guided antibody engineering, we developed CD98hc-targeted central nervous system (CNS) shuttles with broad cross-species reactivity and similar affinities. These bispecific antibodies achieve efficient and sustained brain delivery, overcoming key translational barriers and enabling preclinical evaluation without the use of surrogate antibodies or humanized models.

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Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells

Nature Biomedical Engineering, Published online: 07 July 2026; doi:10.1038/s41551-026-01738-zChemRNAs are chemically synthesized RNA lacking typical mRNA features that are nevertheless efficiently translated by CD8+ T cells to overcome limitations associated with in vitro transcription for developing anti-cancer mRNA vaccines.

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Rewiring tumour mechanosensing to overcome CAR T cell resistance

Nature Biomedical Engineering, Published online: 06 July 2026; doi:10.1038/s41551-026-01731-6A genetic circuit sensing microenvironment softness-induced calcium signalling can be rewired to express a synthetic antigen, boosting chimeric antigen receptor (CAR) T cell killing of stem-like tumour cells.

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AI-orchestrated design–build–test–learn is the future of mammalian biodesign

Nature Biomedical Engineering, Published online: 06 July 2026; doi:10.1038/s41551-026-01730-7Mammalian biodesign increasingly demands decisions that are hard to make with intuition and trial and error alone. Placing virtual cell and tissue models at the centre of an artificial intelligence-orchestrated design–build–test–learn loop turns discovery into a disciplined engineering practice that prioritizes decision quality, shortens iteration and improves translational reliability.

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Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours

Nature Biomedical Engineering, Published online: 06 July 2026; doi:10.1038/s41551-026-01722-7A calcium-activated genetic recorder identifies cancer cells made resistant by soft matrices and can be reprogrammed to express a tumour antigen that restores effective CAR-T cell killing.

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