A micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by attenuating cGAS–STING–type I IFN signaling in macrophages - Nature Cancer

Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-ass...

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IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial - Nature Cancer

In the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial, Platten and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant ...

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GPNMB-directed CAR-T cell therapies for solid tumors - Nature Cancer

Target discovery remains a considerable challenge in the development and translation of chimeric antigen receptor (CAR)-T cell therapies for solid tumors. Two reports in Nature and Nature Cancer now d...

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Iron-mediated ferroptosis impairs CAR-T cell function and antitumor efficacy - Nature Cancer

Huang and colleagues report that elevated iron levels are associated with ferroptosis of chimeric antigen receptor (CAR)-T cells and inhibition of ferroptosis improves antitumor efficacy of CAR-T cell...

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Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes - Nature Cancer

Jin et al. developed an artificial intelligence tool that leverages histology to predict methylation-based central nervous system tumor subtypes and validated it for tumor classification, demonstratin...

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Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma - Nature Cancer

In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...

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Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma - Nature Cancer

In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...

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CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells - Nature Cancer

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibitin...

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Harnessing myeloid cell plasticity for cancer therapy - Nature Cancer

Gabrilovich and colleagues provide an overview of myeloid cell plasticity during differentiation, within the tumor microenvironment and in response to therapy, and discuss the challenges to therapeuti...

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Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial - Nature Cancer

Johanns and colleagues report the results (including safety, efficacy and immunogenicity) of a phase 1 clinical trial of a DNA-based personalized therapeutic cancer vaccine administered following surg...

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Cellular neighborhoods in cancer - Nature Cancer

Tan and colleagues discuss recent advances in spatial omics and computational models that inform the classification and clinical relevance of cellular neighborhoods in cancer.

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Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study - Nature Cancer

In this paper, Steeghs and colleagues report the safety, activity, pharmacokinetic and pharmacodynamic results of a phase 1 dose-escalation trial with MP0317 (FAP x CD40 DARPin) monotherapy in patients with advanced solid tumors.

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Heterogeneity and plasticity of cancer-associated fibroblasts - Nature Cancer

Sherman and colleagues provide an overview of the current understanding of the heterogeneity and plasticity of cancer-associated fibroblasts.

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Epithelial-to-mesenchymal transition as a central driver of tumor cell plasticity - Nature Cancer

Jimenez-Castaño and Nieto review the latest research on cellular plasticity associated with epithelial–mesenchymal transition (EMT) states in cancer cells, highlighting the contributions of EMT to tum...

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Cancer Neuroscience: from mechanisms to therapy

With this collection, Nature Communications, Nature, Nature Cancer, Nature Neuroscience, Nature Progress Oncology, Nature Progress Brain Health, and ...

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Predictive value of early PSMA upregulation for the response to enzalutamide ± 177Lu-PSMA-617 in poor-risk, metastatic, castration-resistant prostate cancer: substudy of the randomized, phase 2 ENZA-p...

Emmett and colleagues evaluate the frequency, magnitude and clinical significance of early prostate-specific membrane antigen (PSMA) upregulation in patients with metastatic castrate-resistant prostat...

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Multi-omic characterization of nasopharyngeal carcinoma delineates the subtype-specific landscape of response to induction chemotherapy - Nature Cancer

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

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Advances in predicting T cell epitope recognition for cancer immunotherapy - Nature Cancer

Gfeller et al. discuss the recent technological and computational advances in prediction of TCR–epitope recognition and the therapeutic applications in cancer immunotherapy.

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Single-cell and spatial profiling in cancer biology and clinical oncology - Nature Cancer

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...

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Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling - Nature Cancer

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hy...

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PRET is a few-shot system for pan-cancer recognition without example training - Nature Cancer

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks...

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Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma - Nature Cancer

Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cel...

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Tucatinib–trastuzumab–capecitabine for treatment of leptomeningeal metastasis in women with HER2+ breast cancer: TBCRC049 phase 2 study results - Nature Cancer

Murthy and colleagues discussed recent research on the effect of a tucanitib–trastuzumab–capecitabine regimen in patients with HER2+ breast cancer and leptomeningeal metastasis.

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Associate or Senior Editor, Nature Cancer

Job Title: Associate or Senior Editor, Nature Cancer Location: Beijing, Madrid, Nanjing or Shanghai - Hybrid working model  Applications Deadline: 29th March About Springer Nature Springer Nature is o...

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