Diabetes in China: epidemiology, pathophysiology and multi-omics - Nature Metabolism

In this Review, the authors summarize epidemiological trends of type 2 diabetes in China, discuss unique risk factors contributing to diabetes risk in the Chinese population and highlight how recent advances from multi-omics studies can affect treatment of diabetes in China.

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Cellular and organismal function of choline metabolism - Nature Metabolism

Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

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The perineurium integrates leptin with its sympathetic outflow to protect against obesity - Nature Metabolism

Lepr+Adrb2+ sympathetic perineurial cells coordinate leptin signalling and sympathetic output to modulate energy expenditure, thermogenesis and body weight in male mice, independent of changes to food intake.

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Palmitoylation modulates neutrophil anti-tumour function in liver metastasis

Nature Metabolism, Published online: 05 August 2026; doi:10.1038/s42255-026-01581-1How liver metastases evade immunity remains unclear. A new study published in Nature Metabolism reveals that DHHC17-driven laminin 511 palmitoylation and its subsequent secretion blunts neutrophil-mediated killing of metastatic cancer cells, uncovering a druggable immune checkpoint in the liver.

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Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour

Nature Metabolism, Published online: 05 August 2026; doi:10.1038/s42255-026-01582-0DHHC17-mediated palmitoylation promotes laminin-511 stabilization and availability in the liver metastatic niche, which decreases the cancer cell-killing capacity of neutrophils.

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Short-chain fatty acids

Nature Metabolism, Published online: 29 July 2026; doi:10.1038/s42255-026-01579-9This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases.

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Metabolic Messengers: small extracellular vesicles - Nature Metabolism

Olefsky, Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history, role as biomarkers, mechanisms of action and therapeutic potential.

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Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism

This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

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Host metabolism can produce many indoles and phenols independently of the microbiome - Nature Metabolism

This study demonstrates that many physiologically important circulating indole and phenol metabolites are derived from host metabolism.

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A non-classical biosynthetic route enables tocopherol synthesis in bacteria

Nature Metabolism, Published online: 27 July 2026; doi:10.1038/s42255-026-01576-yThe study reports a non-classical tocopherol pathway in Rhodobacter that enables heterologous α-tocopherol synthesis by bypassing DMPBQ via a γ/β-tocopherol methyltransferase.

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Mitochondrial quality control in human ageing and longevity - Nature Metabolism

Picca and Ferrucci synthesize current knowledge on mitochondrial quality control (MQC) mechanisms, their regulation during human ageing and their relevance to healthspan and longevity, highlighting emerging therapeutic strategies targeting MQC to mitigate age-related decline and disease.

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Author Correction: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL

Nature Metabolism, Published online: 31 July 2026; doi:10.1038/s42255-026-01597-7Author Correction: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL

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Cancer cachexia: multilevel metabolic dysfunction - Nature Metabolism

In this Review, the authors highlight cancer cachexia as a complex and multifactorial disorder, and discuss the underlying host-driven and tumour-driven metabolic changes, therapeutic opportunities and the pertinent challenges in the treatment of cancer cachexia.

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Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism

Nature Metabolism, Published online: 24 July 2026; doi:10.1038/s42255-026-01575-zThe study employs region-specific knockout of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in either the area postrema or hypothalamus of mice to determine how GIPR agonism and antagonism regulate food intake and body weight via distinct brain regions.

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AI-READI: rethinking AI data collection, preparation and sharing in diabetes research and beyond - Nature Metabolism

Here, we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI), a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type 2 diabetes mellitus.

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Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer

Nature Metabolism, Published online: 23 July 2026; doi:10.1038/s42255-026-01578-wMitochondrial oxidative metabolism is found to strongly affect the response of colorectal cancer (CRC) cells to the chemotherapeutic drug 5-fluorouracil (5FU). Targeting mitochondrial metabolism sensitizes CRC cells to 5FU.

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Exploring pancreatic beta-cell subgroups and their connectivity - Nature Metabolism

Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved and its potential role in islet physiology and diabetes.

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Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics

Nature Metabolism, Published online: 22 July 2026; doi:10.1038/s42255-026-01557-1This study demonstrates that lipids in ascites impair T cell activation through disrupting TCR dynamics, which has translational implications for adoptive T cell therapies.

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Ascites-derived lipid barrier at the T cell synapse

Nature Metabolism, Published online: 22 July 2026; doi:10.1038/s42255-026-01564-2Ovarian cancer ascites can blunt T cell attack, but the earliest steps affected have remained unclear. In this issue of Nature Metabolism, Brown et al. show that ascites-derived lipids disrupt T cell receptor organization and early activation, revealing a synaptic barrier to immunity.

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Polyendocrine metabolic ovarian syndrome — a new name for an old problem - Nature Metabolism

The recent global consensus to rename polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) accurately reframes the condition as a lifelong, multisystemic disorder rather than a localized ovarian pathology. This transition underscores the central role of metabolic dysfunction, specifically the high prevalence of insulin resistance and hyperinsulinaemia, and has important consequences for basic and clinical research.

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Short-chain fatty acids

Nature Metabolism, Published online: 29 July 2026; doi:10.1038/s42255-026-01579-9This Review provides an overview of the biology of short-chain fatty acids, with a focus on their synthesis, signalling and physiological effects, highlighting their translational potential for metabolic and inflammatory diseases.

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GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management - Nature Metabolism

Holst reflects on the development of GLP-1-based drugs for the therapy of obesity, from early observations to remarkable results in more recent clinical trials, discussing physiological, pharmacological and clinical considerations related to their use.

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Metabolism as the biochemical language for mechanistic biomedical AI - Nature Metabolism

Artificial intelligence (AI) excels at prediction but often remains disconnected from biological mechanisms. We propose that metabolism may serve as a biochemical language through which AI systems can gain mechanistic understanding of how molecular states govern physiological function.

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The impact of microbial metabolites on host chromatin and epigenetic regulation

Nature Metabolism, Published online: 21 July 2026; doi:10.1038/s42255-026-01577-xThis Perspective describes the emerging roles of microbiota-derived metabolites in influencing host chromatin and thereby gene regulation and host physiology.

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On the pathogenesis of obesity: causal models and missing pieces of the puzzle - Nature Metabolism

This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.

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Microbial catalysts unlock vitamin bioproduction

Nature Metabolism, Published online: 27 July 2026; doi:10.1038/s42255-026-01584-yThe sustainable production of vitamin E in microbial cell factories has been restricted to tocotrienol derivatives. In this issue of Nature Metabolism, Zhang, Li and Cao et al. leverage non-classical enzymatic catalysts that are endogenous to Rhodobacter species to engineer a microbial chassis that produces tocopherols at gram scale.

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A non-classical biosynthetic route enables tocopherol synthesis in bacteria

Nature Metabolism, Published online: 27 July 2026; doi:10.1038/s42255-026-01576-yThe study reports a non-classical tocopherol pathway in Rhodobacter that enables heterologous α-tocopherol synthesis by bypassing DMPBQ via a γ/β-tocopherol methyltransferase.

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A brief guide to studying extracellular vesicle function in the context of metabolism - Nature Metabolism

Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

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Metabolic Messengers: itaconate - Nature Metabolism

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

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A safety guide for transgenic Cre drivers in metabolism - Nature Metabolism

Despite the high utility and widespread use of Cre driver lines, lack of Cre specificity, Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research.

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