Allogeneic immunotherapy

Nature Reviews Bioengineering, Published online: 05 August 2026; doi:10.1038/s44222-026-00468-wStem cell engineering is expanding the scope of cell-based allogeneic immunotherapy beyond conventional peripheral blood mononuclear cell-derived approaches. This Review highlights advances in genetic modification and differentiation platforms that enable scalable production of T cells, natural killer cells and macrophages with enhanced functionality, safety and immune tolerance, and discusses emerging clinical evidence and therapeutic potential.

dlvr.it

The unmet need for cervicovaginal biosensors

Nature Reviews Bioengineering, Published online: 03 August 2026; doi:10.1038/s44222-026-00482-yDespite advances in precision medicine, continuous biomarker monitoring for women’s health is largely unavailable. The cervicovaginal tract is an ideal site for tracking biologically and clinically relevant biomarkers. Multiplexed sensor technologies could enable early diagnosis and improve gynaecological health, but substantial challenges remain.

dlvr.it

Electroecology for biohybrid and robotic systems

Nature Reviews Bioengineering, Published online: 03 August 2026; doi:10.1038/s44222-026-00481-zExogenous electric fields enable sensory perception and information exchange between organisms and their surroundings, influencing vital processes from pollination to microbial metabolism. Integrating electroecological principles into bioengineering could support the development of new energy sources, robots and biohybrid systems that interact with organisms and ecosystems.

dlvr.it

The unmet need for cervicovaginal biosensors

Nature Reviews Bioengineering, Published online: 03 August 2026; doi:10.1038/s44222-026-00482-yDespite advances in precision medicine, continuous biomarker monitoring for women’s health is largely unavailable. The cervicovaginal tract is an ideal site for tracking biologically and clinically relevant biomarkers. Multiplexed sensor technologies could enable early diagnosis and improve gynaecological health, but substantial challenges remain.

dlvr.it

Electroecology for biohybrid and robotic systems

Nature Reviews Bioengineering, Published online: 03 August 2026; doi:10.1038/s44222-026-00481-zExogenous electric fields enable sensory perception and information exchange between organisms and their surroundings, influencing vital processes from pollination to microbial metabolism. Integrating electroecological principles into bioengineering could support the development of new energy sources, robots and biohybrid systems that interact with organisms and ecosystems.

dlvr.it

Bioiontronics

Nature Reviews Bioengineering, Published online: 28 July 2026; doi:10.1038/s44222-026-00471-1Bioiontronics enables communication with living systems through controlled ion and biomolecule transport at abiotic–biotic interfaces. This Review outlines the mechanisms and emerging device prototypes driving the field and discusses key challenges in ion control, miniaturization, biocompatible fabrication, as well as diagnostic and therapeutic applications.

dlvr.it

Bioiontronics

Nature Reviews Bioengineering, Published online: 28 July 2026; doi:10.1038/s44222-026-00471-1Bioiontronics enables communication with living systems through controlled ion and biomolecule transport at abiotic–biotic interfaces. This Review outlines the mechanisms and emerging device prototypes driving the field and discusses key challenges in ion control, miniaturization, biocompatible fabrication, as well as diagnostic and therapeutic applications.

dlvr.it

New approach methodologies to reduce reliance on animal toxicity testing

Nature Reviews Bioengineering, Published online: 22 July 2026; doi:10.1038/s44222-026-00480-0New approach methodologies are transforming safety science towards more human-relevant, mechanistic models. Bioengineers are central to this shift, but their impact depends on delivering systems that are relevant, robust, scalable and bridge the research-to-regulation gap.

dlvr.it

New approach methodologies to reduce reliance on animal toxicity testing

Nature Reviews Bioengineering, Published online: 22 July 2026; doi:10.1038/s44222-026-00480-0New approach methodologies are transforming safety science towards more human-relevant, mechanistic models. Bioengineers are central to this shift, but their impact depends on delivering systems that are relevant, robust, scalable and bridge the research-to-regulation gap.

dlvr.it

Bioengineering needs systems thinking

Nature Reviews Bioengineering, Published online: 14 July 2026; doi:10.1038/s44222-026-00469-9Bioengineering succeeds or fails as a system, not as a collection of optimized parts. From closed-loop devices to cell therapies, organ chips and synthetic circuits, systems engineering can help convert independently optimized components into robust, validated and usable technologies that work across laboratories, clinics and everyday life.

dlvr.it

Bioengineering needs systems thinking

Nature Reviews Bioengineering, Published online: 14 July 2026; doi:10.1038/s44222-026-00469-9Bioengineering succeeds or fails as a system, not as a collection of optimized parts. From closed-loop devices to cell therapies, organ chips and synthetic circuits, systems engineering can help convert independently optimized components into robust, validated and usable technologies that work across laboratories, clinics and everyday life.

dlvr.it

Soft robotic phantoms for ethical and multimodal surgical simulation

Nature Reviews Bioengineering, Published online: 13 July 2026; doi:10.1038/s44222-026-00474-ySurgical phantoms are artificial models of human tissues used for training, preoperative planning and device testing. Soft robotics is transforming these systems from passive anatomical replicas into dynamic, sensorized and multimodal systems, enabling more realistic surgical training and reducing reliance on animal models.

dlvr.it

Soft robotic phantoms for ethical and multimodal surgical simulation

Nature Reviews Bioengineering, Published online: 13 July 2026; doi:10.1038/s44222-026-00474-ySurgical phantoms are artificial models of human tissues used for training, preoperative planning and device testing. Soft robotics is transforming these systems from passive anatomical replicas into dynamic, sensorized and multimodal systems, enabling more realistic surgical training and reducing reliance on animal models.

dlvr.it

CAR-T cells reshape the tumour microenvironment

Nature Reviews Bioengineering, Published online: 08 July 2026; doi:10.1038/s44222-026-00472-0Analyses of tumour microenvironments (TMEs) in the context of chimeric antigen receptor T cell (CAR-T cell) therapy development typically focus on how the TME impacts CAR-T cells and how to engineer CAR-T cells to overcome barriers present in the TME. However, CAR-T cells can also alter the TME, and greater understanding of this interaction can be leveraged for the development of next-generation CAR-T cell therapies.

dlvr.it

Digital Biomarkers Conference 2027

The Nature Conference ‘Digital Biomarkers’ will take place at ETH Zurich 3-4 February 2027, bringing together global experts to explore the development, application and clinical translatio...

natureconferences.streamgo.live

CAR-T cells reshape the tumour microenvironment

Nature Reviews Bioengineering, Published online: 08 July 2026; doi:10.1038/s44222-026-00472-0Analyses of tumour microenvironments (TMEs) in the context of chimeric antigen receptor T cell (CAR-T cell) therapy development typically focus on how the TME impacts CAR-T cells and how to engineer CAR-T cells to overcome barriers present in the TME. However, CAR-T cells can also alter the TME, and greater understanding of this interaction can be leveraged for the development of next-generation CAR-T cell therapies.

dlvr.it

Computational approaches in bioprinting processes

Nature Reviews Bioengineering, Published online: 03 July 2026; doi:10.1038/s44222-026-00455-1Computational simulations are emerging as powerful complements to bioprinting, enabling prediction of bioink behaviours, shear effects and printability across extrusion-based, droplet-based and light-based techniques. This Review outlines key modelling frameworks, rheological considerations, major applications and remaining challenges, highlighting how simulations can streamline workflows and guide future bioprinting advances.

dlvr.it

Computational approaches in bioprinting processes

Nature Reviews Bioengineering, Published online: 03 July 2026; doi:10.1038/s44222-026-00455-1Computational simulations are emerging as powerful complements to bioprinting, enabling prediction of bioink behaviours, shear effects and printability across extrusion-based, droplet-based and light-based techniques. This Review outlines key modelling frameworks, rheological considerations, major applications and remaining challenges, highlighting how simulations can streamline workflows and guide future bioprinting advances.

dlvr.it

CRISPR-based ex vivo gene editing of donor organs

Nature Reviews Bioengineering, Published online: 29 June 2026; doi:10.1038/s44222-026-00462-2Donor organs are frequently discarded because of concerns about quality or pathogen risk, challenges that could be mitigated through ex vivo gene editing or silencing during machine perfusion. Here, we discuss the development of CRISPR-based approaches for ex vivo gene silencing in human donor organs, from proof of concept in kidney biopsies to the challenges of organ-scale translation.

dlvr.it

CRISPR-based ex vivo gene editing of donor organs

Nature Reviews Bioengineering, Published online: 29 June 2026; doi:10.1038/s44222-026-00462-2Donor organs are frequently discarded because of concerns about quality or pathogen risk, challenges that could be mitigated through ex vivo gene editing or silencing during machine perfusion. Here, we discuss the development of CRISPR-based approaches for ex vivo gene silencing in human donor organs, from proof of concept in kidney biopsies to the challenges of organ-scale translation.

dlvr.it

Antigen-presenting nanoparticles for in vivo CAR T cell engineering

Nature Reviews Bioengineering, Published online: 25 June 2026; doi:10.1038/s44222-026-00467-xIn vivo cell engineering enables chimeric antigen receptor (CAR) production directly within the body. Most in vivo CAR approaches target broad T cell populations. However, antigen-presenting nanoparticles could be used to engineer specific T cell subsets, leveraging the phenotypic and functional properties of the cells for T cell therapy.

dlvr.it

Decentralized molecular diagnostics for viral diseases

Nature Reviews Bioengineering, Published online: 24 June 2026; doi:10.1038/s44222-026-00456-0Viral diseases continue to impose a major global health burden, yet substantial inequities in access to accurate molecular diagnostics persist, limiting effective surveillance and response. This Review highlights disparities in diagnostic availability, evaluates key molecular diagnostic technologies suited for decentralized settings, and outlines essential factors for translating molecular tests into diverse real-world contexts.

dlvr.it

Antigen-presenting nanoparticles for in vivo CAR T cell engineering

Nature Reviews Bioengineering, Published online: 25 June 2026; doi:10.1038/s44222-026-00467-xIn vivo cell engineering enables chimeric antigen receptor (CAR) production directly within the body. Most in vivo CAR approaches target broad T cell populations. However, antigen-presenting nanoparticles could be used to engineer specific T cell subsets, leveraging the phenotypic and functional properties of the cells for T cell therapy.

dlvr.it

Decentralized molecular diagnostics for viral diseases

Nature Reviews Bioengineering, Published online: 24 June 2026; doi:10.1038/s44222-026-00456-0Viral diseases continue to impose a major global health burden, yet substantial inequities in access to accurate molecular diagnostics persist, limiting effective surveillance and response. This Review highlights disparities in diagnostic availability, evaluates key molecular diagnostic technologies suited for decentralized settings, and outlines essential factors for translating molecular tests into diverse real-world contexts.

dlvr.it

Integrating experimental and computational approaches for protein–protein interaction discovery

Nature Reviews Bioengineering, Published online: 22 June 2026; doi:10.1038/s44222-026-00464-0Protein–protein interactions organize cellular processes and are essential for understanding disease and enabling drug discovery. This Review examines how a combination of experimental techniques and computational approaches can be used to map and predict protein–protein interactions, highlighting how integrative strategies are key to achieving comprehensive and reliable interactome maps.

dlvr.it

Pregnancy-associated organs-on-chips

Nature Reviews Bioengineering, Published online: 22 June 2026; doi:10.1038/s44222-026-00459-xPregnancy-associated organs-on-chips (PAOOCs) are microphysiological systems that model gestational tissues to unveil the mechanisms of obstetric conditions and evaluate drug safety and efficacy during pregnancy in vitro. In this Review, we discuss the biological and mechanical components of PAOOCs and propose design recommendations to improve their physiological fidelity, reproducibility and accessibility.

dlvr.it

Menstrual blood for health and disease monitoring

Nature Reviews Bioengineering, Published online: 22 June 2026; doi:10.1038/s44222-026-00465-zMenstrual blood is one of the most information-rich biofluids humans produce. Devices to analyse menstrual blood can enable non-invasive, longitudinal monitoring of reproductive, inflammatory, metabolic and oncological conditions.

dlvr.it

Menstrual blood for health and disease monitoring

Nature Reviews Bioengineering, Published online: 22 June 2026; doi:10.1038/s44222-026-00465-zMenstrual blood is one of the most information-rich biofluids humans produce. Devices to analyse menstrual blood can enable non-invasive, longitudinal monitoring of reproductive, inflammatory, metabolic and oncological conditions.

dlvr.it

Pregnancy-associated organs-on-chips

Nature Reviews Bioengineering, Published online: 22 June 2026; doi:10.1038/s44222-026-00459-xPregnancy-associated organs-on-chips (PAOOCs) are microphysiological systems that model gestational tissues to unveil the mechanisms of obstetric conditions and evaluate drug safety and efficacy during pregnancy in vitro. In this Review, we discuss the biological and mechanical components of PAOOCs and propose design recommendations to improve their physiological fidelity, reproducibility and accessibility.

dlvr.it