Who gets told what is impossible? - Nature Reviews Cancer

Twenty-five years after the launch of Nature Reviews Cancer, the experiences of women in cancer research have changed in important ways, with gains in visibility, representation and recognition. In this World View, Joyce reflects on the progress achieved and the persistent structural barriers that continue to impede equity.

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Converging engineered models of cancer and artificial intelligence

Nature Reviews Cancer, Published online: 03 August 2026; doi:10.1038/s41568-026-00966-4No existing model can reliably predict how an individual cancer will evolve. In this Comment, Guimarães and Reis argue that the future of precision oncology lies not in increasingly sophisticated in vitro tumour models or in artificial intelligence alone, but in the iterative feedback loop between the two.

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Igniting antitumour immunity with cancer cell pyroptosis - Nature Reviews Cancer

In this Review, Liu et al. discuss how pyroptosis, executed by a family of pore-forming proteins known as gasdermins, can induce antitumour immunity, which might be therapeutically leveraged for synergy with existing cancer immunotherapies.

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Accelerated ageing confers early-onset cancer risk

Nature Reviews Cancer, Published online: 03 August 2026; doi:10.1038/s41568-026-00967-3Tian et al. conducted an observational cohort study utilizing data from biobanks in the UK and USA, finding that more advanced biological ageing compared to chronological age may be a risk factor for early-onset solid cancers with implications for cancer prevention and early interception.

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A viral coding circRNA contributes to HPV-driven oncogenesis - Nature Reviews Cancer

In this Journal Club, Muñoz-Bello and Lizano discuss the discovery of circE7, a protein-coding circular RNA generated by back-splicing in high-risk HPV that drives E7 expression and tumour growth, revealing a previously unappreciated mechanism of viral oncogene regulation.

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The DNA damage response and cancer immunotherapy

Nature Reviews Cancer, Published online: 28 July 2026; doi:10.1038/s41568-026-00958-4In this Review, Hong and Li explore how defects in DNA damage response (DDR) pathways shape tumour immunogenicity and influence responses to immune checkpoint inhibitors. They highlight shared immunological consequences across distinct DDR alterations, discuss mechanisms of resistance and evaluate therapeutic strategies integrating DDR-targeting agents with immunotherapy to improve clinical outcomes.

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Who gets told what is impossible?

Nature Reviews Cancer, Published online: 27 July 2026; doi:10.1038/s41568-026-00961-9Twenty-five years after the launch of Nature Reviews Cancer, the experiences of women in cancer research have changed in important ways, with gains in visibility, representation and recognition. In this World View, Joyce reflects on the progress achieved and the persistent structural barriers that continue to impede equity.

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Igniting antitumour immunity with cancer cell pyroptosis

Nature Reviews Cancer, Published online: 27 July 2026; doi:10.1038/s41568-026-00959-3In this Review, Liu et al. discuss how pyroptosis, executed by a family of pore-forming proteins known as gasdermins, can induce antitumour immunity, which might be therapeutically leveraged for synergy with existing cancer immunotherapies.

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Cuproptosis promotes antitumour immunity - Nature Reviews Cancer

In a recent study, Lei, Lu, Xu et al. identify cuproptosis as a form of immunogenic cell death that stimulates adaptive antitumour immunity. In turn, CD8⁺ T cell-derived IFNγ enhances tumour sensitivity to cuproptosis through STAT1–IRF1–FDX1 signalling, establishing a reciprocal immunometabolic circuit with important implications for cancer immunotherapy.

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GABA takes the edge off anti-tumour immunity - Nature Reviews Cancer

Glioblastoma exhibits sex-specific differences in disease progression, incidence and immune regulation. Now, Pathak et al. identify GABA (γ-aminobutyric acid) as a key driver of granulocytic myeloid-derived suppressor cell-mediated glioblastoma progression in women.

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A viral coding circRNA contributes to HPV-driven oncogenesis

Nature Reviews Cancer, Published online: 21 July 2026; doi:10.1038/s41568-026-00962-8In this Journal Club, Muñoz-Bello and Lizano discuss the discovery of circE7, a protein-coding circular RNA generated by back-splicing in high-risk HPV that drives E7 expression and tumour growth, revealing a previously unappreciated mechanism of viral oncogene regulation.

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Cuproptosis promotes antitumour immunity

Nature Reviews Cancer, Published online: 15 July 2026; doi:10.1038/s41568-026-00964-6In a recent study, Lei, Lu, Xu et al. identify cuproptosis as a form of immunogenic cell death that stimulates adaptive antitumour immunity. In turn, CD8⁺ T cell-derived IFNγ enhances tumour sensitivity to cuproptosis through STAT1–IRF1–FDX1 signalling, establishing a reciprocal immunometabolic circuit with important implications for cancer immunotherapy.

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GABA takes the edge off anti-tumour immunity

Nature Reviews Cancer, Published online: 15 July 2026; doi:10.1038/s41568-026-00963-7Glioblastoma exhibits sex-specific differences in disease progression, incidence and immune regulation. Now, Pathak et al. identify GABA (γ-aminobutyric acid) as a key driver of granulocytic myeloid-derived suppressor cell-mediated glioblastoma progression in women.

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A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia - Nature Reviews Cancer

In this Review, Iacobucci and Mullighan discuss how advances in genomic, transcriptomic and epigenomic profiling of acute lymphoblastic leukaemia have revealed molecular heterogeneity, lineage plasticity and mechanisms of treatment resistance in both B cell and T cell disease, thereby refining risk stratification and informing therapeutic decision-making.

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Escaping the trap - Nature Reviews Cancer

A recent study identifies TEX264-dependent nucleophagy as an important mechanism that mediates the clearance of trapped PARP1, thereby limiting PARP1-induced toxicity and promoting resistance to PARP inhibitors.

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Systemic health impact of cancer-associated extracellular vesicles and particles - Nature Reviews Cancer

In this Review, Wang et al. describe how extracellular vesicles and particles contribute to the systemic effects of cancer by providing a form of intercellular communication between tumours and the host through the transfer of bioactive cargo to recipient cells. These systemic effects include immune dysregulation in pre-metastatic niches, thrombosis and cardiovascular disease, liver metabolic dysfunction, glucose metabolism disorders and cachexia, suggesting that holistic approaches to cancer treatment are necessary to simultaneously target the tumour and its multi-organ paraneoplastic effects.

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Imaging the hallmarks of cancer - Nature Reviews Cancer

In this Review, Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice.

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Serving sulfur to boost anti-tumour immunity - Nature Reviews Cancer

Gut microbiome composition and metabolite profiles have previously been linked to both colorectal tumorigenesis and immune checkpoint inhibitor responsiveness. Now, Lobel et al. identify sulfur amino acid metabolism as a microorganism-derived metabolic pathway that enhances anti-tumour immunity.

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Escaping the trap

Nature Reviews Cancer, Published online: 02 July 2026; doi:10.1038/s41568-026-00957-5A recent study identifies TEX264-dependent nucleophagy as an important mechanism that mediates the clearance of trapped PARP1, thereby limiting PARP1-induced toxicity and promoting resistance to PARP inhibitors.

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A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia

Nature Reviews Cancer, Published online: 02 July 2026; doi:10.1038/s41568-026-00951-xIn this Review, Iacobucci and Mullighan discuss how advances in genomic, transcriptomic and epigenomic profiling of acute lymphoblastic leukaemia have revealed molecular heterogeneity, lineage plasticity and mechanisms of treatment resistance in both B cell and T cell disease, thereby refining risk stratification and informing therapeutic decision-making.

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How to give a bad talk - Nature Reviews Cancer

Effective presentations require clarity and audience awareness. In this Comment, Itai Yanai outlines common misconceptions about presentations and how to address them to deliver more impactful and insightful talks.

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Systemic health impact of cancer-associated extracellular vesicles and particles

Nature Reviews Cancer, Published online: 01 July 2026; doi:10.1038/s41568-026-00952-wIn this Review, Wang et al. describe how extracellular vesicles and particles contribute to the systemic effects of cancer by providing a form of intercellular communication between tumours and the host through the transfer of bioactive cargo to recipient cells. These systemic effects include immune dysregulation in pre-metastatic niches, thrombosis and cardiovascular disease, liver metabolic dysfunction, glucose metabolism disorders and cachexia, suggesting that holistic approaches to cancer treatment are necessary to simultaneously target the tumour and its multi-organ paraneoplastic effects.

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CLIM-TIME links tumour genetics to spatial immune architecture

Nature Reviews Cancer, Published online: 29 June 2026; doi:10.1038/s41568-026-00956-6In this Tools of the Trade, Weiwei Hu describes the development and use of CLIM-TIME, a scalable in vivo platform that integrates CRISPR perturbation screens with spatially resolved transcriptomic and immune profiling to link tumour-intrinsic genetic alterations to distinct immune microenvironments.

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Imaging the hallmarks of cancer

Nature Reviews Cancer, Published online: 29 June 2026; doi:10.1038/s41568-026-00950-yIn this Review, Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice.

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Serving sulfur to boost anti-tumour immunity

Nature Reviews Cancer, Published online: 25 June 2026; doi:10.1038/s41568-026-00955-7Gut microbiome composition and metabolite profiles have previously been linked to both colorectal tumorigenesis and immune checkpoint inhibitor responsiveness. Now, Lobel et al. identify sulfur amino acid metabolism as a microorganism-derived metabolic pathway that enhances anti-tumour immunity.

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How to give a bad talk

Nature Reviews Cancer, Published online: 24 June 2026; doi:10.1038/s41568-026-00954-8Effective presentations require clarity and audience awareness. In this Comment, Itai Yanai outlines common misconceptions about presentations and how to address them to deliver more impactful and insightful talks.

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Beyond oncogenesis: the unexplored benefits of viruses in cancer immunity - Nature Reviews Cancer

The study of tumour virology has traditionally focused on oncogenic viruses and their associated mechanisms of cancer initiation and promotion. Yet certain viral exposures can be beneficial by enhancing antitumour immunity. In this Review, Wang et al. explore the increasingly emerging evidence of protective roles of viruses in cancer immunity and how this knowledge could be harnessed to develop a virome-guided framework for cancer immunoprevention.

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3D multi-omics tumour atlases: from technology to biology and clinical translation - Nature Reviews Cancer

In this Review, Liu et al. describe the established and emerging tools for the generation of comprehensive 3D tumour atlases, the analysis of which has the potential to uncover novel biomarkers for risk stratification, early detection, preventive interventions, and transformative diagnostic and treatment strategies.

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