Post-mitotic cardiomyocyte senescence redefines cardiac ageing

Nature Reviews Cardiology, Published online: 03 August 2026; doi:10.1038/s41569-026-01332-5Ilias Simon and Yohan Santin discuss the study that demonstrated that post-mitotic cardiomyocytes can acquire a senescent phenotype with age.

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Social determinants of cardiovascular health: lessons from Whitehall

Nature Reviews Cardiology, Published online: 03 August 2026; doi:10.1038/s41569-026-01333-4Benjamin Dowsing describes the Whitehall studies, which established the inverse relationship between socioeconomic status and the risk of death from coronary heart disease, leading to the concept of social determinants of health.

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Mitochondrial uncoupling therapy reduces established atherosclerosis in mice

Nature Reviews Cardiology, Published online: 28 July 2026; doi:10.1038/s41569-026-01330-7Targeting systemic metabolism through mild mitochondrial uncoupling with a controlled-release mitochondrial protonophore can reduce atherosclerosis in a mouse model of cardiometabolic syndrome, even when administered at late stages of disease progression.

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Cardioprotective properties of empagliflozin and other SGLT2 inhibitors

Nature Reviews Cardiology, Published online: 27 July 2026; doi:10.1038/s41569-026-01325-4In this Review, Zelniker and Braunwald summarize the cardioprotective effects of empagliflozin and other sodium–glucose cotransporter 2 inhibitors and discuss the underlying mechanisms of these effects, including haemodynamic modulation, improved mitochondrial bioenergetics and activation of cytoprotective pathways that inhibit oxidative stress, inflammation and fibrosis.

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The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing

Nature Reviews Cardiology, Published online: 23 July 2026; doi:10.1038/s41569-026-01322-7In this Review, Wang and Dobreva discuss nuclear and chromatin organization and remodelling during cardiac development, disease and ageing, highlight emerging methods to investigate nuclear architecture, describe how mechanical and metabolic signals shape the cardiac 4D nucleome, and examine the therapeutic and translational implications for cardiovascular health and disease.

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The renaissance of cardiac glycosides in heart failure: why, for whom and when

Nature Reviews Cardiology, Published online: 17 July 2026; doi:10.1038/s41569-026-01323-6Cardiac glycosides were the cornerstone of heart failure treatment for decades, but their use progressively declined after the introduction of modern prognostic medications. Two clinical trials now report that cardiac glycosides can reduce the risk of worsening heart failure events in patients with heart failure with reduced ejection fraction. These results do not mandate a paradigm shift but support a specific role for cardiac glycosides in selected patients.

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YAP at the heart of cardiac regeneration

Nature Reviews Cardiology, Published online: 16 July 2026; doi:10.1038/s41569-026-01328-1In this Journal Club article, Dar describes the first study to report the transcriptional coactivator YAP as a central regulator of cardiac regeneration in mice.

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In the era of AI, omics and organoids, animal models are still needed in cardiovascular research

Nature Reviews Cardiology, Published online: 14 July 2026; doi:10.1038/s41569-026-01327-2As artificial intelligence (AI), multiomics and human organoids reshape cardiovascular research, calls to replace animal models are accelerating. We argue that understanding complex, multiorgan cardiovascular disease requires an integrated framework in which in vivo, in vitro and computational models each provide complementary biological insights.

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World Heart Federation Roadmap on cardiac rehabilitation: a pathway to lifelong cardiovascular health

Nature Reviews Cardiology, Published online: 13 July 2026; doi:10.1038/s41569-026-01312-9In this Roadmap from the World Heart Federation, cardiac rehabilitation is reframed as programmes to promote lifelong cardiovascular health. Redfern et al. identify roadblocks and propose multifaceted solutions, together with international case studies of successful implementation.

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Transfer of a gain-of-function PCSK9 gene to induce atherosclerosis in mice

Nature Reviews Cardiology, Published online: 08 July 2026; doi:10.1038/s41569-026-01326-3In this Tools of the Trade article, Albarrán-Juárez describes the utility of the adeno-associated virus-PCSK9 model of atherosclerosis.

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Sarcomere dysfunction as the molecular basis of hypertrophic cardiomyopathy

Nature Reviews Cardiology, Published online: 08 July 2026; doi:10.1038/s41569-026-01324-5Dababneh and Roston describe the studies that first demonstrated that variants in genes encoding sarcomere proteins are the main cause of hypertrophic cardiomyopathy.

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Epidemiology and determinants of cardiovascular disease in Indigenous populations

Nature Reviews Cardiology, Published online: 07 July 2026; doi:10.1038/s41569-026-01314-7In this Review, Brown and colleagues collate contemporary epidemiological data on cardiovascular disease in the Indigenous populations of Aotearoa New Zealand, Australia, Canada and the USA. The authors explore the potential drivers of inequalities in cardiovascular outcomes between Indigenous and non-Indigenous populations, as well as pathways for change in the pursuit of equity in cardiovascular health.

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The origin of clinical left ventricular ejection fraction measurement

Nature Reviews Cardiology, Published online: 03 July 2026; doi:10.1038/s41569-026-01321-8The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.

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Inclusive cardiovascular care for sexual and gender minority populations

Nature Reviews Cardiology, Published online: 26 June 2026; doi:10.1038/s41569-026-01320-9Guidance is limited on how to move beyond the recognition of disparities in cardiovascular care among sexual and gender minority (SGM) adults towards scalable health-care delivery that both supports risk assessment for and improves prevention of cardiovascular disease. We propose key components of cardiovascular programmes for SGM adults, including clinical scope, multidisciplinary health-care teams, SGM-specific considerations and measurable quality outcomes.

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Modular cardiac microtissues for interrogating cell-type contributions

Nature Reviews Cardiology, Published online: 24 June 2026; doi:10.1038/s41569-026-01319-2In this Tools of the Trade article, Lees and Lim describe a human modular cardiac microtissue platform used in their research laboratory that allows the contribution of each cell type to be established within an otherwise-intact human engineered cardiac tissue.

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Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis

Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.

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Epigenetic regulation in atherosclerosis and its therapeutic potential

Nature Reviews Cardiology, Published online: 19 June 2026; doi:10.1038/s41569-026-01313-8In this Review, Santovito and colleagues provide an overview of epigenetic regulation in atherosclerosis, focusing on how epigenetic modifications guide cell-specific transcriptional programmes in vascular endothelial cells, vascular smooth muscle cells, and immune cells to regulate cell plasticity and intercellular communication. They also discuss translational opportunities and the challenges of using epigenetic drugs to treat atherosclerotic cardiovascular disease.

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Coronary artery calcium on chest CT scans: from incidental finding to mandatory reporting

Nature Reviews Cardiology, Published online: 18 June 2026; doi:10.1038/s41569-026-01317-4Coronary artery calcium visible on routine, low-dose, non-contrast, chest computed tomography (CT) scans provides clinically relevant information about cardiovascular risk, without additional radiation exposure or cost. Mandatory systematic reporting of coronary artery calcium findings, supported by artificial intelligence and standardized workflows, could transform and elevate an often-overlooked, incidental finding into a practical tool in preventive cardiovascular care.

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Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers

Nature Reviews Cardiology, Published online: 18 June 2026; doi:10.1038/s41569-026-01301-yIn this Review, Okazaki and colleagues provide an overview of the phenotypic presentations of mitochondrial cardiomyopathy, describe the underlying molecular mechanisms and genetic causes, and summarize the latest diagnostic modalities and emerging treatment strategies.

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Role of systemic and epicardial adipose tissue in cardiometabolic disease

Nature Reviews Cardiology, Published online: 16 June 2026; doi:10.1038/s41569-026-01304-9In this Review, Nerlekar and colleagues describe how the collective biology of adipose depots, rather than quantity alone, drives cardiometabolic risk, highlight how patterns of fat distribution specific to sex and ethnicity can modulate this risk, and summarize numerous pharmacological interventions to target adipose tissue for the reduction of cardiometabolic risk.

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Heart rate monitoring during everyday use of smartphones

Nature Reviews Cardiology, Published online: 15 June 2026; doi:10.1038/s41569-026-01316-5Researchers have developed a deep learning system that uses short videos of the face passively recorded during everyday use of smartphones to monitor heart rate and resting heart rate. The system was validated under laboratory and free-living conditions and across a range of skin tones.

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Promising results with stem-cell-derived tissue transplantation in heart failure

Nature Reviews Cardiology, Published online: 09 June 2026; doi:10.1038/s41569-026-01315-6In patients with advanced, symptomatic heart failure with reduced ejection fraction refractory to guideline-directed therapy, transplantation of a tissue allograft produced from induced pluripotent stem cells promotes heart remuscularization and leads to increases in heart wall thickness, left ventricular ejection fraction and quality of life at 3 months, according to an interim analysis of the ongoing, phase I–II BioVAT-HF clinical trial.

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The direction of cardiomyocyte growth is orchestrated by microtubule dynamics

Nature Reviews Cardiology, Published online: 04 June 2026; doi:10.1038/s41569-026-01311-wA new study shows that the microtube network directs cardiomyocyte growth through two mechanisms: by redirecting the localization of mRNA and protein synthesis and by modifying the intercalated disc, the site of cell–cell adhesion at the ends of the cardiomyocyte.

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Management and long-term surveillance of hypertensive disorders of pregnancy

Nature Reviews Cardiology, Published online: 28 May 2026; doi:10.1038/s41569-026-01309-4Hypertensive disorders experienced during pregnancy can continue to increase cardiovascular risk after childbirth. However, adequate follow-up (including blood pressure management, risk stratification and cardiometabolic prevention) is not always incorporated into postpartum care. A life-course pathway that integrates surveillance and targeted interventions could reduce inequities and improve long-term cardiovascular outcomes.

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MicroRNA-132 inhibitor is well-tolerated in patients with MI and LV dysfunction

Nature Reviews Cardiology, Published online: 27 May 2026; doi:10.1038/s41569-026-01308-5In the randomized, phase II HF-REVERT trial, the miR-132 inhibitor CDR132L was well-tolerated and showed pharmacodynamic target engagement in patients with myocardial infarction and reduced left ventricular ejection fraction, but did not improve ventricular remodelling compared with placebo.

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The beating heart as a tumour-suppressive niche

Nature Reviews Cardiology, Published online: 21 May 2026; doi:10.1038/s41569-026-01307-6The beating of the heart does more than circulate blood; its rhythmic contractions generate forces to create a biomechanical environment that suppresses tumour growth. This finding, from a new study by Ciucci and colleagues, highlights an underappreciated role for cardiac mechanics in cancer biology.

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Eugene Braunwald (1929–2026)

Nature Reviews Cardiology, Published online: 20 May 2026; doi:10.1038/s41569-026-01303-wIn this Obituary, Peter Libby reflects on the life and achievements of Eugene Braunwald, celebrated as the father of modern cardiology.

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