Nature Reviews Immunology
@natrevimmunol.nature.com
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
August issue of NRI now online: www.nature.com/nri/volumes/... Cover inspired by a Review of cytokine multimerization by Ina Rudloff and colleagues @hudsonresearch.bsky.social Also featuring Reviews on: T cell lymphomas Antiviral CD8 T cell immunity Metabolite regulation of macrophages in obesity
Two Journal Clubs from @preprintclub.bsky.social: A lympahtic circuit that sustains antitumour immune surveillance rdcu.be/fwpyt by @sandhyadav.bsky.social & @dmitriyzamarin.bsky.social Drug holidays restore exhausted T cell responses to PD1 blockade rdcu.be/fwpxu by Chih-Wei Chu & Kenneth Hu
This World View article by Sarah Teichmann @scicambridge.bsky.social argues that "biological understanding is deepened, not diminished, when we let data speak before hypothesis" rdcu.be/fv91L
ICYMI: How Big Data and AI are revolutionizing human immunology
How Big Data and AI are revolutionizing human immunology
Nature Reviews Immunology, Published online: 23 July 2026; doi:10.1038/s41577-026-01340-zUnderstanding human biology in health and disease has entered a new era, one defined not just by better tools but by a fundamental shift in how biological knowledge is generated.
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ICYMI: A lymphatic circuit that sustains antitumour immune surveillance
A lymphatic circuit that sustains antitumour immune surveillance
Nature Reviews Immunology, Published online: 22 July 2026; doi:10.1038/s41577-026-01342-xA preprint by Delclaux et al. reports that dendritic cells recirculate tumour antigen to the draining lymph nodes to re-engage tumour-egressed T cells and sustain the antitumour response.
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How Big Data and AI are revolutionizing human immunology
How Big Data and AI are revolutionizing human immunology
Nature Reviews Immunology, Published online: 23 July 2026; doi:10.1038/s41577-026-01340-zUnderstanding human biology in health and disease has entered a new era, one defined not just by better tools but by a fundamental shift in how biological knowledge is generated.
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A lymphatic circuit that sustains antitumour immune surveillance
A lymphatic circuit that sustains antitumour immune surveillance
Nature Reviews Immunology, Published online: 22 July 2026; doi:10.1038/s41577-026-01342-xA preprint by Delclaux et al. reports that dendritic cells recirculate tumour antigen to the draining lymph nodes to re-engage tumour-egressed T cells and sustain the antitumour response.
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ICYMI: Drug holidays restore exhausted T cell responses to PD1 blockade
Drug holidays restore exhausted T cell responses to PD1 blockade
Nature Reviews Immunology, Published online: 21 July 2026; doi:10.1038/s41577-026-01343-wA preprint by Ngiow et al. shows that intermittent PD1 blockade incorporating a ‘drug holiday’ preserves the proliferative and differentiation capacity of progenitor exhausted T cells.
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Drug holidays restore exhausted T cell responses to PD1 blockade
Drug holidays restore exhausted T cell responses to PD1 blockade
Nature Reviews Immunology, Published online: 21 July 2026; doi:10.1038/s41577-026-01343-wA preprint by Ngiow et al. shows that intermittent PD1 blockade incorporating a ‘drug holiday’ preserves the proliferative and differentiation capacity of progenitor exhausted T cells.
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In this Comment article, @miriammerad.bsky.social summarises our increasing appreciation that tissue-resident macrophages are "evolutionarily conserved guardians of biological integrity". www.nature.com/articles/s41...
Macrophages are constitutive architects of tissue integrity - Nature Reviews Immunology
The lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of mac...
nature.com
ICYMI: Macrophages are constitutive architects of tissue integrity
Macrophages are constitutive architects of tissue integrity
Nature Reviews Immunology, Published online: 17 July 2026; doi:10.1038/s41577-026-01334-xThe lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of macrophages and offers untapped therapeutic targets in these cells.
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ICYMI: Interleukin-18 armours antitumour immune effectors
Interleukin-18 armours antitumour immune effectors
Nature Reviews Immunology, Published online: 16 July 2026; doi:10.1038/s41577-026-01330-1Interleukin-18 (IL-18) shapes tumour immunity through tightly regulated, context-dependent effects on T cells, NK cells and the tumour microenvironment. Emerging therapeutic strategies, including engineered cellular therapies and decoy-resistant variants, aim to harness IL-18 signalling to enhance antitumour responses while overcoming regulatory constraints.
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Macrophages are constitutive architects of tissue integrity
Macrophages are constitutive architects of tissue integrity
Nature Reviews Immunology, Published online: 17 July 2026; doi:10.1038/s41577-026-01334-xThe lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of macrophages and offers untapped therapeutic targets in these cells.
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ICYMI: Programming macrophage polarization with synthetic cytokine receptors
Programming macrophage polarization with synthetic cytokine receptors
Nature Reviews Immunology, Published online: 14 July 2026; doi:10.1038/s41577-026-01338-7A preprint by Lunger et al. reports macrophage engineering through constitutively active synthetic cytokine receptors to induce polarization states that are unobtainable with natural cytokine receptors.
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Journal club article by @tomikostevc.bsky.social & @sawitzkilab.bsky.social discussing a recent #preprint from @sciencekyle.bsky.social that uses a synthetic cytokine receptor to simultaneously induce inflammatory and phagocytic phenotypes in a macrophage rdcu.be/ftTPx
Programming macrophage polarization with synthetic cytokine receptors - Nature Reviews Immunology
A preprint by Lunger et al. reports macrophage engineering through constitutively active synthetic cytokine receptors to induce polarization states that are unobtainable with natural cytokine receptor...
nature.com
Many thanks @natrevimmunol.nature.com for featuring our preprint through your Journal Club initiative – such a valuable program for supporting training in peer review!
Nature Reviews Immunology@natrevimmunol.nature.com · last mo.ICYMI: Glycolytic capacity instructs tumour vasculature and response to immunotherapy
Programming macrophage polarization with synthetic cytokine receptors
Programming macrophage polarization with synthetic cytokine receptors
Nature Reviews Immunology, Published online: 14 July 2026; doi:10.1038/s41577-026-01338-7A preprint by Lunger et al. reports macrophage engineering through constitutively active synthetic cytokine receptors to induce polarization states that are unobtainable with natural cytokine receptors.
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ICYMI: The challenge and promise of studying human antigen-specific T cells
The challenge and promise of studying human antigen-specific T cells
Nature Reviews Immunology, Published online: 13 July 2026; doi:10.1038/s41577-026-01331-0Antigen-specific T cells underpin immunity, cancer surveillance and autoimmunity, yet remain difficult to study. This Review describes the technologies and computational approaches that are helping to link T cell receptor specificity with function, revealing how intrinsic T cell properties shape immune outcomes across infection, vaccination and disease.
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The challenge and promise of studying human antigen-specific T cells
The challenge and promise of studying human antigen-specific T cells
Nature Reviews Immunology, Published online: 13 July 2026; doi:10.1038/s41577-026-01331-0Antigen-specific T cells underpin immunity, cancer surveillance and autoimmunity, yet remain difficult to study. This Review describes the technologies and computational approaches that are helping to link T cell receptor specificity with function, revealing how intrinsic T cell properties shape immune outcomes across infection, vaccination and disease.
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ICYMI: Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis
Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis
Nature Reviews Immunology, Published online: 10 July 2026; doi:10.1038/s41577-026-01336-9A study by Tian et al. reports that psychological stress suppresses neuronal activity in brain regions that innervate the gut, leading to intestinal dysbiosis, reduced production of spermidine and ferroptotic stress of HSCs.
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ICYMI: Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
Nature Reviews Immunology, Published online: 09 July 2026; doi:10.1038/s41577-026-01339-6Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
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Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis
Psychological stress in mice induces ageing-like HSC dysfunction through intestinal dysbiosis
Nature Reviews Immunology, Published online: 10 July 2026; doi:10.1038/s41577-026-01336-9A study by Tian et al. reports that psychological stress suppresses neuronal activity in brain regions that innervate the gut, leading to intestinal dysbiosis, reduced production of spermidine and ferroptotic stress of HSCs.
dlvr.it
Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
Nature Reviews Immunology, Published online: 09 July 2026; doi:10.1038/s41577-026-01339-6Author Correction: Shaping neutrophil morphology and function: the importance of a segmented nucleus
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Are you an immunologist or environmental scientist with an interest in human health? Join our upcoming scientific meeting on the topic of the exposome and chronic inflammatory diseases. You can also apply to present a poster at the meeting. royalsociety.org/science-even...
ICYMI: A guide to CAR T cell therapies: development, current status and future prospects
A guide to CAR T cell therapies: development, current status and future prospects
Nature Reviews Immunology, Published online: 02 July 2026; doi:10.1038/s41577-026-01322-1This Review traces the development of chimeric antigen receptor (CAR) T cell therapy from foundational immunology to approved products, highlighting clinical successes, engineering advances, safety strategies and ongoing challenges in extending durable responses beyond haematological malignancies.
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NEW Review: A guide to CAR T cell therapies by @hindrafei.bsky.social, Ranjan Upadhyay & @pamsharmamdphd.bsky.social @mdanderson.bsky.social traces the development of CAR T cells from foundational discoveries to approved products www.nature.com/articles/s41...
ICYMI: Macrophages in embryonic development
Macrophages in embryonic development
Nature Reviews Immunology, Published online: 01 July 2026; doi:10.1038/s41577-026-01327-wThis Review discusses the origins and roles of macrophages in embryonic development. The authors highlight the importance of macrophages for development of the haematopoietic and immune systems and for the establishment of immune tolerance in early life.
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