Neutron spin echo spectroscopy - Nature Reviews Methods Primers

Neutron spin echo spectroscopy investigates internal dynamics and diffusion in materials, using advanced instruments and data collection techniques. In this Primer, Faraone et al. discuss how neutron ...

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Peptide ligand discovery of G protein-coupled receptors - Nature Reviews Methods Primers

Peptides have become an increasingly important and versatile ligand type for G protein-coupled receptors (GPCRs). In this Primer, Hermes et al. discuss the experimental and computational workflow...

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Distributional regression using generalized additive models for location, scale and shape - Nature Reviews Methods Primers

Distributional regression models entire conditional response distributions. In this Primer, Merder et al. discuss how distributional regression is used to predict uncertainty and extreme conditions in...

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Synthesis and applications of conductive polymers - Nature Reviews Methods Primers

Conductive polymers (CPs) are π-conjugated organic semiconductors that exhibit electrical conductivities similar to insulators and metals while maintaining the flexibility of plastics. This Primer pro...

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Solid-state laser cooling - Nature Reviews Methods Primers

Solid-state laser cooling is a technique used to lower the temperature of a condensed-phase system through its interaction with light. In this Primer, Ding et al. discuss the fundamental principles of...

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Matrix-assisted laser desorption/ionization imaging mass spectrometry - Nature Reviews Methods Primers

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a label-free molecular imaging approach mapping diverse biomolecules at cellular resolution. In this Primer, Spragg...

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Cucurbit[n]uril-type molecular containers - Nature Reviews Methods Primers

Cucurbit[n]urils are macrocyclic host molecules that form strong complexes with hydrophobic and cationic guests in water, where n is the number of glycoluril units. Cucurbit[n]urils complexed with gue...

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Enzyme tethering for in situ epigenomics - Nature Reviews Methods Primers

Enzyme-tethering epigenomic methods modify DNA while cells and nuclei remain intact, making them particularly suitable for single-cell and spatial applications. In this Primer, Kami Ahmad et al. discu...

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Magnetic tunnel junctions - Nature Reviews Methods Primers

Atomic-scale engineering of MgO-based magnetic tunnel junctions enables coherent spin-dependent tunnelling and large tunnelling magnetoresistance for advanced spintronic functionality. This Primer out...

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It takes two combs to tango

Atoms and molecules are the fundamental building blocks of matter. Spectroscopy identifies and quantifies chemical species through the unique spectral fingerprints they imprint on light. Spectroscopy ...

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Dual-comb spectroscopy - Nature Reviews Methods Primers

Dual-comb spectroscopy utilizes two optical frequency combs for precise, rapid measurements, enhancing performance through time-domain interferometry. This Primer discusses the experimental set-up and...

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Transient absorption spectroscopy - Nature Reviews Methods Primers

Transient absorption spectroscopy is a pump–probe method used to investigate light-induced dynamics. In this Primer, He et al. describe various transient absorption set-ups and outline a workflow for ...

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Flow NMR for chemical synthesis - Nature Reviews Methods Primers

Flow NMR spectroscopy offers real-time monitoring of chemical reactions, enabling quantitative analysis and mechanistic insights. This Primer describes the specialized equipment and tailored methods t...

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Laser Doppler vibrometry - Nature Reviews Methods Primers

This Primer provides a comprehensive overview of laser Doppler vibrometry, covering fundamental principles, advanced measurement methods and diverse applications. It highlights performance limits, mea...

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#ScientistAtWork photo competition

A celebration of the striking and colourful work that scientists do around the world.

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Expansion microscopy - Nature Reviews Methods Primers

Expansion microscopy enhances conventional imaging by physically enlarging samples within a hydrogel matrix, surpassing diffraction limits. In this Primer, Vo et al. detail typical expansion microscop...

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When the plant becomes the material: rethinking nanoherbicide design through plant-informed nanodesign - Nature Reviews Methods Primers

Current nanoherbicide development is largely guided by a material-first design logic that overlooks the biological complexity determining nanoparticle transport, transformation and target-site access in plants. We propose plant-informed nanodesign; a biology-driven framework that integrates plant physiology into rational nanocarrier engineering, advancing the field from empirical screening towards predictive science.

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Precision genome editing with DNA base editors - Nature Reviews Methods Primers

Base editing enables precise, programmable single-base changes using cytosine or adenine editors. This Primer outlines their use in mammalian cells for screening, disease modelling and therapy, covering experimental design, analysis, limitations and best-practice guidance to support effective implementation.

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Magnetoresistance phenomena and measurement methodologies - Nature Reviews Methods Primers

Magnetoresistance is a fundamental transport phenomenon that provides deep insight into electronic structure, magnetic order and emergent quantum effects in solids. This Primer reviews major magnetore...

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‘How to’ Comments

This ongoing Series of ‘How to’ Comments offers expert guidance and recommendations on a wide range of topics relevant to the broad readership of Nature Human ...

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Ultrafast nano-imaging and nano-spectroscopy - Nature Reviews Methods Primers

Ultrafast near-field microscopy unites femtosecond optical spectroscopy with nanometre spatial resolution to image non-equilibrium material dynamics beyond the diffraction limit. This Primer outlines ...

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Hyperspectral imaging - Nature Reviews Methods Primers

This Primer introduces hyperspectral imaging (HSI) through a concise, imaging-centric perspective, linking sensor platforms, data types and representative datasets across application domains. It highl...

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Quantum imaging with correlated photon pairs - Nature Reviews Methods Primers

This Primer provides an introduction to quantum imaging with correlated photon pairs, from core concepts to experimental realizations. It discusses potential advantages over classical imaging, practic...

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Fluidic force microscopy - Nature Reviews Methods Primers

Fluidic force microscopy combines atomic force microscopy with microfluidic probes to enable measurement and manipulation of materials at sub-micrometre resolution. In this Primer, Zambelli et al. dis...

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Materials design for the future with AI assistance - Nature Reviews Methods Primers

Advancements in artificial intelligence and machine learning are reshaping scientific research, with notable benefits for materials design and modelling. We spoke with Aron Walsh, Professor in Materia...

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Electrophoretic deposition - Nature Reviews Methods Primers

Electrophoretic deposition is a micropatterning method that utilizes suspension properties and kinetic parameters for film control. This Primer discusses innovative electrode design to enhance resolut...

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Setting the standard on chemistry terms and symbols - Nature Reviews Methods Primers

Clear, consistent communication is essential in science and a goal Nature Reviews Methods Primers addresses with the ‘Reproducibility and data deposition’ section in Primers. Here, Brynn Hibbert of th...

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The growing role of reproducibility networks - Nature Reviews Methods Primers

The UK Reproducibility Network (UKRN) was established to promote robust and transparent research and drive research quality. Here, Marcus Munafò, a founding member of the UKRN, outlines the role of Re...

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Design for end of life: how circularity can offer a different path for solar energy - Nature Reviews Methods Primers

With the rising success of solar photovoltaics, long-term sustainability needs to be addressed. We provide practical steps that researchers, journals and the wider community can take to embed circular...

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