A coupled TOM–TIM22 supercomplex in human mitochondrial protein import

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01852-1TOM and TIM22 complexes facilitate the transport of carrier protein substrates into mitochondria. New work shows that, in human mitochondria, these two protein complexes form transient supercomplexes to facilitate protein biogenesis.

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Variant characterization in the intrinsically disordered human proteome

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01846-zProteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

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Factors modulating the assembly of human β2-adrenergic receptor–β-arrestin complexes

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01842-3Wilhelm, Pluhackova and colleagues show how ligand binding, receptor phosphorylation and membrane interactions, including PIP2, drive the assembly of human β2-adrenergic receptor–β-arrestin complexes, providing insight into structural mechanisms regulating GPCR signaling.

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A coupled TOM–TIM22 supercomplex in human mitochondrial protein import

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01852-1TOM and TIM22 complexes facilitate the transport of carrier protein substrates into mitochondria. New work shows that, in human mitochondria, these two protein complexes form transient supercomplexes to facilitate protein biogenesis.

dlvr.it

Variant characterization in the intrinsically disordered human proteome

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01846-zProteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

dlvr.it

Factors modulating the assembly of human β2-adrenergic receptor–β-arrestin complexes

Nature Structural & Molecular Biology, Published online: 31 July 2026; doi:10.1038/s41594-026-01842-3Wilhelm, Pluhackova and colleagues show how ligand binding, receptor phosphorylation and membrane interactions, including PIP2, drive the assembly of human β2-adrenergic receptor–β-arrestin complexes, providing insight into structural mechanisms regulating GPCR signaling.

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Protein thiol alterations drive pathologic liquid–liquid phase separation in the aging brain

Nature Structural & Molecular Biology, Published online: 30 July 2026; doi:10.1038/s41594-026-01857-wVignane et al. show that age-related protein oxidation disrupts normal brain protein organization, promoting harmful condensates and aggregation linked to neurodegeneration, whereas hydrogen sulfide-driven persulfidation counteracts these effects.

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A protective ESCRT sleeve for ultrafine DNA bridges

Nature Structural & Molecular Biology, Published online: 29 July 2026; doi:10.1038/s41594-026-01856-xDNA bridges, thin DNA connections that link daughter cells after division, threaten genome integrity and can trigger catastrophic chromosome rearrangements. A new study proposes that ESCRT-III proteins form protective assemblies around fragile ultrafine DNA bridges, revealing an unexpected role for these membrane-remodeling complexes in genome protection.

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Protein thiol alterations drive pathologic liquid–liquid phase separation in the aging brain

Nature Structural & Molecular Biology, Published online: 30 July 2026; doi:10.1038/s41594-026-01857-wVignane et al. show that age-related protein oxidation disrupts normal brain protein organization, promoting harmful condensates and aggregation linked to neurodegeneration, whereas hydrogen sulfide-driven persulfidation counteracts these effects.

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A protective ESCRT sleeve for ultrafine DNA bridges

Nature Structural & Molecular Biology, Published online: 29 July 2026; doi:10.1038/s41594-026-01856-xDNA bridges, thin DNA connections that link daughter cells after division, threaten genome integrity and can trigger catastrophic chromosome rearrangements. A new study proposes that ESCRT-III proteins form protective assemblies around fragile ultrafine DNA bridges, revealing an unexpected role for these membrane-remodeling complexes in genome protection.

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Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase

Nature Structural & Molecular Biology, Published online: 23 July 2026; doi:10.1038/s41594-026-01844-1Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TOPBP1 and ETAA1.

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Direct coupling of human TOM and TIM22 complexes drives mitochondrial carrier import

Nature Structural & Molecular Biology, Published online: 23 July 2026; doi:10.1038/s41594-026-01849-wLiu, Cai and colleagues show that the human TOM–TIM22 supercomplex acts a translocation unit that directly couples mitochondrial carrier import across the outer and inner membranes, in contrast to the independent function of the complexes in yeast.

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License to slice: duplex deformation gates Argonaute catalysis

Nature Structural & Molecular Biology, Published online: 22 July 2026; doi:10.1038/s41594-026-01853-0Human Argonaute2 (AGO2) binds siRNAs to target complementary mRNAs. Although guided–target complementary is required for slicing, there is a wide range of slicing efficacy. A study now shows the precise role guide–target geometry has in slicing efficacy.

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PLA2G2F suppresses ferroptosis through phospholipid remodeling

Nature Structural & Molecular Biology, Published online: 22 July 2026; doi:10.1038/s41594-026-01830-7Hu et al. identify the secretory phospholipase PLA2G2F as an endoplasmic reticulum-resident ferroptosis suppressor in bladder cancer and provide evidence that PLA2G2F acts on ether-linked phospholipids containing polyunsaturated fatty acids, reducing the pool of these peroxidation-prone phospholipids.

dlvr.it

Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase

Nature Structural & Molecular Biology, Published online: 23 July 2026; doi:10.1038/s41594-026-01844-1Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TOPBP1 and ETAA1.

dlvr.it

Direct coupling of human TOM and TIM22 complexes drives mitochondrial carrier import

Nature Structural & Molecular Biology, Published online: 23 July 2026; doi:10.1038/s41594-026-01849-wLiu, Cai and colleagues show that the human TOM–TIM22 supercomplex acts a translocation unit that directly couples mitochondrial carrier import across the outer and inner membranes, in contrast to the independent function of the complexes in yeast.

dlvr.it

License to slice: duplex deformation gates Argonaute catalysis

Nature Structural & Molecular Biology, Published online: 22 July 2026; doi:10.1038/s41594-026-01853-0Human Argonaute2 (AGO2) binds siRNAs to target complementary mRNAs. Although guided–target complementary is required for slicing, there is a wide range of slicing efficacy. A study now shows the precise role guide–target geometry has in slicing efficacy.

dlvr.it

PLA2G2F suppresses ferroptosis through phospholipid remodeling

Nature Structural & Molecular Biology, Published online: 22 July 2026; doi:10.1038/s41594-026-01830-7Hu et al. identify the secretory phospholipase PLA2G2F as an endoplasmic reticulum-resident ferroptosis suppressor in bladder cancer and provide evidence that PLA2G2F acts on ether-linked phospholipids containing polyunsaturated fatty acids, reducing the pool of these peroxidation-prone phospholipids.

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Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter

Nature Structural & Molecular Biology, Published online: 21 July 2026; doi:10.1038/s41594-026-01838-zBelleza, Zhang and colleagues showed that the χ-conotoxin χ-AoIA, a venom-derived peptide, reduces pain in mice by blocking the norepinephrine transporter more effectively than other similar peptides.

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Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter

Nature Structural & Molecular Biology, Published online: 21 July 2026; doi:10.1038/s41594-026-01838-zBelleza, Zhang and colleagues showed that the χ-conotoxin χ-AoIA, a venom-derived peptide, reduces pain in mice by blocking the norepinephrine transporter more effectively than other similar peptides.

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Conformational plasticity of human acid-sensing ion channel 1a

Nature Structural & Molecular Biology, Published online: 16 July 2026; doi:10.1038/s41594-026-01845-0Using cryo-electron microscopy, Cahill, Hartfield et al. identified six structural states of human acid-sensing ion channel 1a, revealing how acidic conditions and peptide toxins regulate channel activation and desensitization through conformational flexibility.

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Increased DNA methylation linked to aging phenotypes in a progeria syndrome

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01851-2Increased DNA methylation linked to aging phenotypes in a progeria syndrome

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In vitro model of the human embryonic disc takes flight

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01848-xIn vitro model of the human embryonic disc takes flight

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Conformational plasticity of human acid-sensing ion channel 1a

Nature Structural & Molecular Biology, Published online: 16 July 2026; doi:10.1038/s41594-026-01845-0Using cryo-electron microscopy, Cahill, Hartfield et al. identified six structural states of human acid-sensing ion channel 1a, revealing how acidic conditions and peptide toxins regulate channel activation and desensitization through conformational flexibility.

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ESCRT-III assembles around mis-segregated DNA to protect genome stability

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01841-4The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.

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Increased DNA methylation linked to aging phenotypes in a progeria syndrome

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01851-2Increased DNA methylation linked to aging phenotypes in a progeria syndrome

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Bridge for lipid delivery

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01847-yBridge for lipid delivery

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In vitro model of the human embryonic disc takes flight

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01848-xIn vitro model of the human embryonic disc takes flight

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ESCRT-III assembles around mis-segregated DNA to protect genome stability

Nature Structural & Molecular Biology, Published online: 15 July 2026; doi:10.1038/s41594-026-01841-4The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.

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CST complex promotes second-strand synthesis in break-induced replication

Nature Structural & Molecular Biology, Published online: 13 July 2026; doi:10.1038/s41594-026-01832-5Here Thakre, Wang and Liu and colleagues show that the Cdc13–Stn1–Ten1 complex helps cells to repair broken DNA by enabling synthesis of the second DNA strand during break-induced replication, a process important for genome stability and telomere maintenance in some cancers.

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