Towards self-driving laboratories in the biopharmaceutical industry - Nature Synthesis

Self-driving laboratories integrate robotics, analytics and AI-driven decision-making to accelerate biopharmaceutical research and development. This Perspective discusses architectures and opportuniti...

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Ordered heteronuclear metal pairs facilitate urea electrosynthesis - Nature Synthesis

Urea electrosynthesis from CO2 and nitrate is limited by poor control over carbon- and nitrogen-derived intermediates. Here ordered Cu–Zn catalytic pairs with symmetry-tuned coordination and subnanome...

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Aziridination of inert alkanes via photo-mediated double hydrogen atom transfer - Nature Synthesis

Bis-functionalization of unactivated alkanes is synthetically challenging and typically requires multiple steps. Now, a method for the direct aziridination of unactivated alkanes is reported, using a ...

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Orbital order observation in intermetallic crystals - Nature Synthesis

Nature Synthesis - Orbital order observation in intermetallic crystals

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Scale-aware self-driving laboratories for multiscale process development - Nature Synthesis

Self-driving laboratories (SDLs) can accelerate scientific discovery, but their broader value lies in supporting scale translation for multiscale process development. SDLs should generate scale-aware ...

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Guiding principles for seeded electrochemical synthesis of multimetallic nanocrystals - Nature Synthesis

Conventional electrodeposition often yields ill-defined morphologies and aggregated nanocrystals. Here, by linking growth behaviour to lattice mismatch and metal–metal bond energy, seed-assisted elect...

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Selective pore modulation in layered molecular crystals - Nature Synthesis

Independently tuning pore sizes and functionalities remains challenging in multi-porous framework materials. Now, triskele-shaped building units enable selective pore modulation in dual-porous hydroge...

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Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water - Nature Synthesis

Conventional hydrazide-based native chemical ligation is often limited by the need for multiple steps and pH adjustments. Now a ferricyanide-mediated oxidation system is reported that enables ligation...

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Electrochemical C(sp3)–C(sp3) cross-coupling of alcohols - Nature Synthesis

Alcohols are regarded as ideal C(sp3) synthons, yet efficient C–O bond activation methods remain scarce for cross-coupling. Now, a Ni-catalysed electrochemical double dehydroxylative cross-coupling fo...

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Cations control CO2 electroreduction - Nature Synthesis

Nature Synthesis - Cations control CO2 electroreduction

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Electrochemical cross-electrophile coupling for carbon–heteroatom and heteroatom–heteroatom bond formation - Nature Synthesis

Electrochemical cross-electrophile coupling (eXEC) has expanded the scope of available reaction tools for carbon–heteroatom and heteroatom–heteroatom bond formation. This Review surveys recent advance...

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Self-driving laboratories need an autonomy safety harness - Nature Synthesis

Industrial self-driving laboratories need more than safe robots and instruments. They need an autonomy safety harness that defines how AI-generated intent becomes executable experiments, monitored act...

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Autonomous laboratories and digital chemistry in industry - Nature Synthesis

Nature Synthesis - Autonomous laboratories and digital chemistry in industry

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Membranes tame methanol in yeast - Nature Synthesis

Membrane lipid remodelling enables methylotrophic yeast Komagataella phaffii to tolerate high methanol concentrations and produce lipids under non-sterile fed-batch fermentation.

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Enantioselective single-atom skeletal editing of bicyclo[1.1.0]butanes by carbene insertion - Nature Synthesis

Owing to competitive strain-induced ring-opening and isomerization side reactions, enantioselective single-atom skeletal editing of saturated carbocycles, particularly bridged hydrocarbons, remains ch...

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Assembly of a bifurcated knot via sequence selective imine condensation - Nature Synthesis

A bifurcated knot is synthesized via two sequential and selective imine condensation reactions. The bifurcated knot contains 3 classical crossing points and 20 bifurcated junctions. This strategy enab...

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Rotaxane synthesis inside out - Nature Synthesis

Nature Synthesis - Rotaxane synthesis inside out

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Enantioconvergent alkylation of boron-stabilized organomagnesiums with unactivated alkyl halides using nickel catalysis - Nature Synthesis

The use of racemic alkylmagnesium reagents in enantioconvergent C(sp3)–C(sp3) cross-coupling reactions is a challenge owing to competing side reactions. Now, a nickel-catalysed enantioconvergent metho...

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β-Selective C(sp3)–H functionalization of alkyl boronates using photoredox catalysis - Nature Synthesis

Alkyl boronates are typically involved in direct C–B bond transformations. Now the use of boronates as directing groups to enable β-selective C(sp3)–H functionalization is reported. The process uses L...

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Multi-walled carbon nanotube network-toughened diamond composite via atomic interface continuity - Nature Synthesis

A toughened diamond composite containing a three-dimensional (3D) multi-walled carbon-nanotube (MWCNT) network with mixed sp2–sp3-hybridized bonding interfaces exhibits a hardness of ~91.6 GPa and a f...

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Synthesis of Z‑allylamines via masked alkenyl anions from alkynyl tetracoordinate boron compounds - Nature Synthesis

A metal-free, three-component cascade reaction enables the stereodefined synthesis of Z-allylamines from alkynyl tetracoordinate boron compounds, amines and aldehydes. The reaction proceeds via masked...

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Dynamic anionic sublattice engineering in perovskite heterostructures for perovskite–silicon tandem solar cells - Nature Synthesis

Dynamic orientational disorder of cyanate anions in perovskite heterostructures is shown to regulate perovskite nucleation kinetics, suppress defect states and enhance carrier mobility. This dynamic a...

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Electrophotocatalysis for direct vicinal dichlorination of carboxylic acids - Nature Synthesis

Electrophotocatalysis merges decarboxylation with adjacent C–H functionalization, enabling direct conversion of aliphatic carboxylic acids into vicinal dichlorides.

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Automated exploration of the Biginelli reaction hyperspace - Nature Synthesis

Systematic, high-dimensional exploration of Biginelli reaction space transforms automated synthesis from an optimization tool into a discovery engine.

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Hyperspace exploration using robotics for the discovery of mechanistically distinct transformations and complex functional products - Nature Synthesis

The hyperspace of reaction conditions of the Biginelli reaction is scanned using a robotic platform, revealing a pseudo-seven-component transformation that yields a bicyclic product featuring rare sup...

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Refactoring pikromycin synthase for the modular biosynthesis of macrolide antibiotics in E. coli - Nature Synthesis

A biosynthetic platform is developed to rapidly construct large, engineered polyketide synthases using the updated module boundary. This system produces a library of macrolide antibiotics in Escherich...

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Membrane remodelling for increased methanol tolerance in Komagataella phaffii - Nature Synthesis

Bioproduction from methanol is often challenging owing to the cytotoxicity of methanol. Here a methanol-tolerant Komagataella phaffii chassis is engineered by overexpressing four membrane genes, incre...

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Electrified direct epoxidation of light hydrocarbons using alkene-binding atomic sites - Nature Synthesis

An indium-doped PtPdOx catalyst is designed for efficient electrochemical propylene epoxidation. Indium incorporation strengthens propylene binding on the catalyst surface and balances its co-adsorpti...

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Metal-free hydrogenation of viologens to piperidine derivatives for bacterial inhibition - Nature Synthesis

A metal-free hydrogenation method converts rigid aromatic viologen units into flexible piperidine-based structures using formic acid. The transformation induces pronounced conformational changes in ma...

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Interface-regulated vapour crystallization for ultrapure perovskite LEDs - Nature Synthesis

An interface-regulated vapour crystallization strategy is reported that enables precise control over the spectral linewidth of solution-processed halide perovskite thin films. The demonstrated perovsk...

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