Tremendous resource paper from NCI-PSRC member Nina Steele on collating a single cell RNA SEQ dataset in #PancreaticCancer The dataset is now housed with the PSRC. aacrjournals.org/clincancerre...

The semi annual virtual meeting of the NCI PSRC is happening now. Here NCI highlights the top ten papers from the consortium thus far.

The incidence of #PancreaticCancer in women with a BRCA1 or BRCA2 mutation acsjournals.onlinelibrary.wiley.com/doi/10.1002/... The cumulative incidence from age 40 to 80 years was 2.2% for BRCA1 carriers and 2.7% for BRCA2 carriers. Most did not have a family history of the disease.

THE DEFINITIVE AGING ATLAS A panoramic view of cell population dynamics in mammalian aging www.science.org/doi/10.1126/... PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes!

A panoramic view of cell population dynamics in mammalian aging

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

science.org

Follow the Associate Members of NCI-PSRC who are on 🦋 @benstanger01.bsky.social @tme-caf-ecm.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @rafrancescone.bsky.social New associate members can be nominated by any of the primary investigators. www.nci-psrc.org/member.html

Recent Cancer Discovery paper by NCI-PSRC investigator @hccvpdac.bsky.social ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma aacrjournals.org/cancerdiscov... Important study on regulators of gastric metaplasia in early #PancreaticCancer & classical variant of PDAC.

ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

The receptor tyrosine kinase ROR2 defines the cellular identity of pancreatic precancerous lesions and confers aggressiveness and therapeutic resistance in cancer.

aacrjournals.org

Pancreatic cancer: Advances and challenges www.cell.com/cell/fulltex... By NCI-PSRC investigators @lyssiotislab.bsky.social @mpm-lab.bsky.social @anirbanmaitra.bsky.social

Pancreatic cancer: Advances and challenges

Enabled by technological development on various fronts, our understanding of the complexity in the biology of pancreatic ductal adenocarcinoma deepens, laying the foundation for promising translation ...

cell.com

Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month: #PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here? aacrjournals.org/cancerres/ar... @kenolivelab.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @tme-caf-ecm.bsky.social

Please see recent publication in Cancer Discovery from NCI-PSRC investigator Andy Aguirre at @danafarber.bsky.social Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer aacrjournals.org/cancerdiscov...

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Analysis of clinical samples from patients with pancreatic cancer and preclinical models treated with KRAS inhibitors identifies diverse mechanisms of resistance and yields new insights for developing...

aacrjournals.org

Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity www.nature.com/articles/s41... The authors have developed Spatial and Cell-type Proteomics (SCPro), capturing the proteomes of #PancreaticCancer tumor microenvironment at single cell resolution.

Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity - Nature Communications

The integration of antibody-guided cell typing and mass spectrometry-based proteomics remains challenging. Here, the authors develop Spatial and Cell-type Proteomics (SCPro), a multimodal spatial prot...

nature.com

Special issue of Carcinogenesis featuring a series of invited articles on advances and challenges in #PancreaticCancer research, honoring the memory of Dr. Perwez Hussein. academic.oup.com/carcin/issue

Issues | Carcinogenesis | Oxford Academic

Publishes original contributions on all aspects of cancer research. Subjects covered include biology, genetics and epigenetics, cancer biomarkers and molecular epidemiology, inflammation, microenviron...

academic.oup.com

The #PancreaticCancer starter pack now has over 100 researchers, advocates and organizations engaged in pancreatic cancer research & advocacy. Please write to @anirbanmaitra.bsky.social if you need to be added. This account will maintain an updated feed of pancreatic cancer research moving forward.

Anirban Maitra@anirbanmaitra.bsky.social · 2y ago

#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW

Please follow the NCI #PancreaticCancer stromal reprogramming consortium on 🦋 Learn more about our program here: www.nci-psrc.org