Dr Christian Nefzger (Uni of QLD) presented at ARMI this week as part of our External Seminar Series. His work shows ageing is a structured process, reusing developmental mechanisms to reshape cell identity. It focuses on how transcription factor networks, including AP-1, regulate these changes.

Ralph Patrick is looking for dosage-sensitive transcription factors that may impact ageing #ASSCR2025 doi.org/10.1016/j.cm...

Really intriguing model of AP-1 driven aging. @anshulkundaje.bsky.social @suragnair.bsky.social - thinking of your AP1-related results in the ChromBPNet paper here...

Christian Nefzger@nefzgerlab.bsky.social · 2y ago

8/9 🧵 Our study indicates that AP-1–linked chromatin opening drives organismal maturation by disrupting the activity of cell identity TFBS-rich early-life REs, thereby progressively shutting down developmental processes to reprogram the transcriptome towards adult tissue function.

🙏 to Manuel Serrano for writing a preview for our study @ Cell Metabolism. A pattern emerges in chromatin aging: AP-1 steals the show dlvr.it/TBvzgR

Thanks to Longevity Technology for writing an article about our recent study: "Master controller of aging and development uncovered. New insights into transcription factors and chromatin remodeling reveal potential for improving age-related health outcomes. #innovation #aging " t.co/a8Mxgowkbe

Thanks to EpiGenie for an article about our study: "Christian Nefzger's lab reveals how chromatin remodeling driven by the AP-1 pioneer transcription factor supports cell maturation. Beware o' the mechanism pirated during #aging to induce the appearance of age-related phenotypes!" bit.ly/3zOqBux

Our recent study in Cell Metabolism provides compelling evidence that chromatin accessibility and transcription factor network remodeling in aging reflect the predictable degrading effects of a mechanism initially driving organismal maturation. Link: doi.org/10.1016/j.cmet.2024.06.006 Thread 🧵👇1/9