Neuroengineering
@neuroengineering.bsky.social
Your (non-addictive) dose of neurotechnology news 🧠⚡️
My highlight of 2025: the first #microelectrode #BCI for spinal cord injury in Europe! 🦾⚡️🧠 🎥 (feature in German) www.ardmediathek.de/video/gesund...
Gesundheit!: KI-Gehirn-Chip bei Querschnittlähmung - hier anschauen
KI-Gehirn-Chip bei Querschnittlähmung: Was bringt ein in das Gehirn implantierter Chip Menschen mit Querschnittlähmung mehr an Lebensqualität und Mobilität?
ardmediathek.de
Frequent BCI recalibration due to changing neural activity mark a significant hurdle in long-term BCI engagement. Researchers at stanford now demonstrate a clever approach enabling unsupervised decoder adaptation by infering task labels and reinforcing the neural decoder #neuroskyence
Long-term unsupervised recalibration of cursor-based intracortical brain–computer interfaces using a hidden Markov model - Nature Biomedical Engineering
A hidden Markov model that uses probabilistic retrospective inference allows for up to one month of unsupervised recalibration in an online cursor-based intracortical brain–machine interface.
nature.com
New study challenges the idea of a unified decision network: Neuropixel recordings in primate OFC showed robust encoding during value-based choices but near-silence during perceptual decisions, even when rewards are at stake. #RewardSignals #neuroskyence www.biorxiv.org/content/10.1...
Selective engagement of the primate orbitofrontal cortex during value-based but not perceptual decisions
A fundamental question in neuroscience is whether the brain uses specialized sub-systems for different types of decisions or relies on a unified decision-making network. The orbitofrontal cortex (OFC)...
biorxiv.org
DARPA-backed brain-computer interface just published in Nat. Electronics: Ken and colleagues present a fully implanted, 50-μm thick ECoG with 65.000 channels on a 256x256 grid. Their system wirelessly transmits power and signals to a relay-coil outside the skull #neuroskyence #neuroAI #compneuro
A wireless subdural-contained brain–computer interface with 65,536 electrodes and 1,024 channels - Nature Electronics
A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–...
nature.com
Speech decoding on the basis of single words has so far been limited to intracranial recordings. Scientists demonstrated the feasibility of non-invasive language decoding using EEG and MEG, finding that more training data consistently increases model performance #neuroskyence #compneuro #neuroAI
Towards decoding individual words from non-invasive brain recordings - Nature Communications
While deep learning has enabled the decoding of language from intracranial brain recordings, achieving this with non-invasive recordings remains an open challenge. Here the authors introduce a deep le...
nature.com
Changing behavior with ultrasound 🔊🧠 Focused ultrasound is shown to reliably modulate deep brain areas such as the nucleus accumbens, comparable to DBS. Stimulation during a reinforcement learning task altered reward expectation, learning curves and task strategy #neuroAI #neuroskyence #compneuro
Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity - Nature Communications
This study shows that non-invasive ultrasound to the human nucleus accumbens can modulate deep brain activity and enhance reward-guided learning, offering a potential alternative to invasive neuromodu...
nature.com
Insular neural interfaces Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications #neuroskyence
Insular error network enables self-correcting intracranial brain-computer interface
Error recognition is fundamental to adaptive behavior, enabling rapid compensatory action when outcomes deviate from expectations. Central to this function are neural circuits for performance monitori...
biorxiv.org
Thalamus for vision BCIs Scientists have recorded single neurons in the human LGN for the first time, revealing how it links the retina to visual cortex. When one eye is closed, neurons tuned to that eye reduce their activity, while neurons tuned to the open eye increase in spikerate #neuroskyence
Effects of eye closure on the spiking activity of human lateral geniculate neurons - Nature Communications
The LGN is a critical stage between the retina and visual cortex, but the properties of human LGN neurons are not fully understood. Here the authors report that they closely resemble those in monkeys ...
nature.com
New article in Nature showing that the superior temporal gyrus (STG) encodes language-specific features stronger when listening to the native language. Bilinguals on the other hand shared this higher-level tuning across both of their familiar languages @changlabucsf.bsky.social #neuroskyence
Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-sp...
nature.com
A race to the brain 🧠 Paradromics has just received FDA IDE approval to implant their micro-electrode array in human participants. The neuralink competitor will soon start recruiting patients with speech/motor impairments at UC Davis, Mass General Hospital and U Michigan #neuroskyence
Paradromics Gets FDA Approval to Trial Its Brain Implant in People
The Austin-based startup will test its high-bandwidth device to help restore speech in people with extremely limited movement.
wired.com
Human superior temporal gyrus (STG) encodes the progression of a word as it unfolds in time. The neural activity tracks relative position within the word, regardless of its length, and resets at each new word boundary. #neuroskyence @changlabucsf.bsky.social
Human cortical dynamics of auditory word form encoding
We perceive continuous speech as a series of discrete words, despite the lack of clear acoustic boundaries. The superior temporal gyrus (STG) encodes …
sciencedirect.com
Towards a bidirectional visual neuroprosthesis 👁️⚡️ Spiking activity near intracortical stimulation sites proved to accurately predict the brightness and sharpness of perception. Using these signals in real time could one day optimize the individualized experience of each phosphene #neuroskyence
Neural correlates of phosphene perception in blind individuals: A step toward a bidirectional cortical visual prosthesis
Visual prostheses are improved by decoding neural signals to predict and control visual perceptions in blind individuals.
science.org
Jeff Bezos increases his bet on Synchron The company behind the stentrode just raised $200M in Series D funding, led by Double point ventures, Bezos Expeditions and ARCH ventures. The funding will be used to develop smaller stentrodes reaching multiple brain regions 🧠 #neuroskyence
Neuralink Rival Synchron Raises $200 Million for Brain Implant
Synchron Inc. raised $200 million to advance its work building brain implants that doctors can insert through blood vessels, avoiding the costly and high-risk surgeries necessary to install devices ma...
bloomberg.com
Treating OCD with neurotechnology Researchers at UCSF used iEEG to map brain circuits in severe OCD, identifying the ventral capsule as bridge between the prefrontal cortex and limbic system. Multi-area DBS implantation led to rapid symptom improvement 🧠 #neuroskyence @changlabucsf.bsky.social
Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity - Translational Psychiatry
Translational Psychiatry - Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity
nature.com
DBS for epilepsy ? Researchers demonstrated that stimulation of the thalamus helped reduce seizures by over 80%. Their approach showed a reduction in epileptiform discharges, in line with the nuclei's critical role in seizure termination #neuroskyence #neuroAI #neuroscience
Thalamocortical hodology to personalize electrical stimulation for focal epilepsy - Nature Communications
Over 50 million people worldwide suffer from epilepsy, and many patients remain resistant to medication. Here, the authors hypothesized that targeting thalamic nuclei with precise anatomical...
nature.com
Bigtime publication on retinal prosthesis @science.xyz implanted 38 patients with macular degeneration with the PRIMA subretinal implant. Paired with camera-equipped glasses, the system improved central vision in 80% of participants, allowing them to read again @maxhodak.bsky.social #neuroskyence
Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD | NEJM
Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in ...
nejm.org
Earl K. Miller@earlkmiller.bsky.social · 10mo agoNew paper: Working memory readout varies with frontal theta rhythms. A theta traveling wave swept across the frontal cortex like radar, modulating performance of a working memory task. Because cognition is rhythmic. www.cell.com/neuron/abstr... #neuroscience @picowerinstitute.bsky.social
🧠 In this behind-the-scenes video, Neuralink's surgery engineering team shows how they build realistic head and brain models from patient CT and MRI scans. These "proxies" let surgeons rehearse each procedure in advance. 🎥 youtube.com/watch?v=WhG-...
How Elon Musk’s Neuralink Builds Fake Brains
YouTube video by Core Memory
youtube.com
A big push for #BCI and #neurotechnology in Europe! We implanted our second microelectrode array #BCI @tum.de. Huge thanks to our pioneer and to fantastic colleagues in #Neurosurgery and #Robotics #Machine #Intelligence 🧠🦾🧪 #neuroskyence @neuroengineering.bsky.social www.tum.de/en/news-and-...
Brain-computer interface for a patient with quadriplegia
A team at the Technical University of Munich’s TUM University Hospital has implanted a brain-computer interface in a patient paralyzed from the neck down.
tum.de
Ultrasound maps deep brain function over months Scientists used functional ultrasound imaging to record from primate parietal cortex over months. Their method combines high spatial resolution and long-term stability, revealing direction-tuned saccadic neural patches #neuroskyence #compneurosky
Functional ultrasound neuroimaging reveals mesoscopic organization of saccades in the lateral intraparietal area - Nature Communications
The functional organization of the posterior parietal cortex (PPC) for guiding eye movements has remained unknown. Here, the authors use functional ultrasound neuroimaging to reveal small, tuned clust...
nature.com
OpenNeuro @openneuro.bsky.social just hit a huge milestone: 1500 datasets! Congrats to the team on making this project so successful over the last 7 years.
🧠⚡️ Can transcranial alternating current stimulation (tACS) truly rhythmically modulate brain activity in humans? More than 30 labs are joining forces in the tACS Challenge, a global effort to test one of brain stimulation's biggest questions. 🧵1/5
Precision Neuroscience published their high-density ECoG in Nature Biomed. Eng. The startup shows a 1,024-channel grid implanted through a cortical slit in pigs, and intraoperative neural recordings and stimulation in five humans at sub-mm resolution. #neuroskyence @precisionneuro.bsky.social
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation - Nature Biomedical Engineering
A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.
nature.com
Can we combine neural data across individuals to improve speech BCIs? A recent study used transfer learning on distributed iEEG recordings to enhance speech decoding. By learning shared latent manifolds, their cross-subject model outperformed individual models in a speech motor task. #neuroskyence
Transfer learning via distributed brain recordings enables reliable speech decoding - Nature Communications
Speech brain-computer interfaces face challenges scaling across individuals with different brain organization. Using minimally invasive recordings from 25 patients, the authors developed transfer learning methods that enable robust speech decoding even with incomplete brain coverage.
nature.com
Optimizing stimulation patterns for visual implants 👁️ Check out @mbeyeler.bsky.social's recent study on using spiking activity to adapt stimulation parameters for more stable and reliable perception #neuroskyence #bci
Michael Beyeler@mbeyeler.bsky.social · 10mo ago👁️🧠 New preprint: We demonstrate the first data-driven neural control framework for a visual cortical implant in a blind human! TL;DR Deep learning lets us synthesize efficient stimulation patterns that reliably evoke percepts, outperforming conventional calibration. www.biorxiv.org/content/10.1...
How does intracortical microstimulation (ICMS) affect the brain? ICMS affects both vascular and immune responses. Higher currents increase blood-brain barrier leakage, letting substances enter surrounding tissue. Soon after, microglia activate and cluster around highly active regions #neuroskyence
Intracortical Microstimulation Induces Rapid Microglia Process Convergence
Intracortical microstimulation (ICMS) has the potential to restore vision and hearing by stimulating relevant cortical regions in both animals and hum…
sciencedirect.com
Better neural decoding using connectomics and emotional states? Check out @julianneumann.bsky.social newest study in Nature Biomed. Eng! #neuroskyence #bci #compneurosky
Wolf-Julian Neumann@julianneumann.bsky.social · 11mo agoNew paper in Nature Biomedical Engineering by @timonmerk.bsky.social ! We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology. www.nature.com/articles/s41...
How does the body regulate blood pressure after SCI? Scientists mapped the precise nerve circuits causing dangerous spikes in mice, rats, and humans. By stimulating these circuits with epidural electrical stimulation, they activated a competing pathway that stabilized blood pressure. #neuroskyence
A neuronal architecture underlying autonomic dysreflexia - Nature
The neuronal architecture that develops after spinal cord injury and causes autonomic dysreflexia is uncovered.
nature.com
