Long V. Nguyen
@nguyenlab.bsky.social
Oncologist-Scientist @ Princess Margaret Cancer Centre & University of Toronto 🇨🇦 Transcriptional plasticity, functional clonal heterogeneity, cancer stem cells 🧬🔬🧫 lvnguyenlab.ca
Honoured to be named one of Canada’s #Top40Under40! Grateful to my mentors, trainees, collaborators, friends and family for their support. Excited to continue advancing #CancerResearch and patient care @uhn.ca @uhnresearch.ca
Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧@carloscaldas1960.bsky.social · last mo.@nguyenlab.bsky.social a top #Caldasian is a top 40 under 40 in Canada! @caldaslab.bsky.social has always been made of stars! I am the luckiest PI and mentor there is! financialpost.com/news/meet-ca...
🚨 Pre-print alert! Kronheim S et al. Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenografts: doi.org/10.64898/202... In collaboration with @carloscaldas1960.bsky.social & @fgaiti.bsky.social #CancerResearch #SingleCell #Chemotherapy #TumorEvolution
doi.org
Important protocol from @nguyenlab.bsky.social that details method used in our paper published recently @cp-cellreports.bsky.social: www.cell.com/cell-reports... www.sciencedirect.com/science/arti...
Protocol to track single-cell-derived clones using DNA barcoding combined with single-cell RNA sequencing
Clonal fitness and plasticity drive tumor heterogeneity contributing to disease progression and treatment resistance. Here, we provide a protocol to t…
sciencedirect.com
Online now: The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
Tu et al. present a systematic analysis of the tumor microenvironment across 14,837 breast cancers, identifying distinct cellular patterns that predict disease-specific survival independently of genomic and intrinsic subtypes. Characterizing microenvironment composition may provide critical prognostic markers that can complement current molecular classification for treatment selection and preventing recurrence.
dlvr.it
My poor laptop wishes I learned how to use the cluster earlier, but it’s sacrifice was not in vain! We learned some important things about the breast cancer tumor microenvironment, described in our paper published today: www.cell.com/cell-reports... Here's the 🧵
Most #cancer cells aren’t able to propagate tumours—but a rare few can. Using genetic barcodes, a team @pmresearch-uhn.bsky.social tracked these rare clones—revealing how they evolve, adapt, and resist treatment. A step toward more targeted cancer therapies. 🔗: www.uhnresearch.ca/news/rare-ca...
I am excited to share the latest publication from the Nguyen, Caldas @carloscaldas1960.bsky.social and Rueda labs @ruedalab.bsky.social. This was a massive effort from a fantastic team and I’m grateful to everyone on the paper for their work on this project! doi.org/10.1016/j.ce... #bcsm #PDTX
Redirecting
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