Nicholas Clifton

@nicl2.bsky.social

Researcher in neuroscience and psychiatric genomics, University of Exeter

For those working in psychiatric genomics and related disciplines: join us next Wednesday as we discuss accurate and trusted science communication. I will cover how researchers can get involved in lending their expertise to educate and combat misinformation, and introduce @authentisci.bsky.social.

Psychiatric Genomics Consortium (PGC)@pgcgenetics.bsky.social · 8mo ago

❗Join us to discuss: ‘Scientifically accurate and ethically responsible science communication in psychiatric genetics’ on 14th Jan ! Organised by the PGC Outreach Committee, BGA Public Science Committee @behaviorgenetic.bsky.social, and @ibangs.bsky.social Register: us02web.zoom.us/webinar/regi...

"Ever feel the need to switch off? Your vagus nerve might hold the key" The review says the article is balanced and quotes experts, but evidence for “vagus nerve training” is weak. Benefits could be placebo, and it shouldn’t replace medical advice. authentisci.com/article/5101...

AuthentiSci review for Ever feel the need to switch off? Your vagus nerve might hold the key

AuthentiSci review for Ever feel the need to switch off? Your vagus nerve might hold the key

authentisci.com

New paper on everyone’s favourite topic, QC! We show why you should do genotype-level QC on your WGS data www.biorxiv.org/content/10.1... Very real quotes about this paper - “The most exciting, mind-blowing paper of the year!” “On a par with Fisher 1918” “I read it every night. Just so beautiful”

Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing

Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...

biorxiv.org

New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...

Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation

AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1

doi.org