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Nicole Robb

@nicolerobb.bsky.social

Associate Professor at Warwick Medical School and Visiting Lecturer at the University of Oxford ❤️RNA viruses, single-molecule microscopy and diagnostics

10 Posts348 Follower376 Folgt
Nicole Robb@nicolerobb.bsky.social · 10mo ago

Really happy to see this out, and delighted to be part of such a nice project! CCHFV is a growing viral threat and understanding how it's L-protein works is massively important for developing strategies to counteract it.

Jeremy Keown@jeremykeown.bsky.social · 10mo ago

www.biorxiv.org/content/10.1... Really excited to have our work out in the world. CCHFV has a 450kDa L-Protein, about twice the size of L-Proteins from other segmented RNA viruses. We have used cryoEM and functional assays to begin to understand it this massive multifunctional protein works.

Achilles Kapanidis@achilleskap.bsky.social · 10mo ago

Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...

High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza

Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in

academic.oup.com

@craigpthomp.bsky.social · 12mo ago

I am very excited to share our preprint: ‘Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses’. The first authors are Lucas Benjamin Stolle, Jai Bolton, Rebecca Steventon & Reanna Gregory. lnkd.in/eeYmfvdE

Yi-Wei Chang@yiweichang.bsky.social · last yr.

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

science.org

Microbiology Society@microbiologysociety.org · 2y ago

“It is really hard for infectious diseases to effectively stop being specialists and move over into a new species. So, when that happens, it is striking and concerning” — Microbiology Society member, Ed Hutchinson, in an important article published in the Guardian yesterday -

Age of the panzootic: scientists warn of more devastating diseases jumping between species

Experts believe H5N1 bird flu belongs in a growing category of infectious diseases that can cause pandemics across many species. But there are ways to reduce the risks

buff.ly

Helen Branswell 🇨🇦@helenbranswell.bsky.social · 2y ago

The lack of severe infections among US #H5N1 #birdflu cases up till now may have created the notion among some people that the virus has become harmless. The death of a person in Louisiana is a reminder that that is not a safe bet. www.statnews.com/2025/01/06/b...

U.S. records first fatal bird flu case amid growing concerns about virus

The U.S. has recorded its first fatal case of H5N1 bird flu, in a person from Louisiana who contracted the virus from infected chickens and wild birds in a backyard flock.

statnews.com

Kai Kupferschmidt@kakape.bsky.social · 2y ago

CDC just confirmed the first severe case of #H5N1 in the US in a patient in Louisiana. This virus seems to be the same genotype D1.1 that is spreading in birds at the moment (so not the cattle genotype B3.13) that severely sickened the teenager in Canada. #IDsky 🧪

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