We recently had to say goodbye to Tala, our feisty but beloved grey tabby, at the age of (almost) 18. She had a good life and we will miss her dearly.
Nima Mosammaparast
@nimamlab.bsky.social
Professor of Pathology at WashU, St. Louis, Co-Director DNA Repair Program @Siteman Cancer Center. Father, husband, immigrant.
To top off the end of 2025, a new preprint from our lab! We find an unanticipated new answer to an old question in DNA repair. www.biorxiv.org/cgi/content/...
Human MutLa activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity
Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of ...
biorxiv.org
A giant will be missed here at WashU. His laboratory was directly above mine. internalmedicine.wustl.edu/obituary-stu...
Obituary: Stuart Arthur Kornfeld, MD - John T. Milliken Department of Medicine
October 4, 1936 – August 17, 2025 It is with deep sadness that I share the news that Dr. Stuart Arthur Kornfeld, Professor Emeritus, passed away on Sunday, August 17, 2025, from complications of Parki...
internalmedicine.wustl.edu
"I think we have a bias as people coming from the tech industry where we worked at companies, you know, such as Google, Facebook, these companies that have plenty of money, are funded by investors and have lots of people kind of sitting around doing nothing." www.npr.org/2025/06/02/n...
Former DOGE engineer says federal waste and fraud were 'relatively nonexistent'
NPR's Juana Summers talks with Sahil Lavingia, who worked for the Department of Government Efficiency as a software engineer assigned to the Department of Veterans Affairs, about his experience.
npr.org
It was forty years ago today that I came to the US with my family to escape war and repression in Iran. I remain thankful and amazed at where life has led me. #freedom
This is why we need science.
Fyodor Urnov@urnov.bsky.social · 2y agoEmily Whitehead's life was saved by an "academic" team at Penn Medicine - this yielded an approved therapy, Kymriah, since used by Novartius to treat ~20,000 patients with cancer. = science at research universities saves lives. Pls read second subunit below. www.cnn.com/2025/03/07/h...
A great pleasure to share our newest paper out this morning @cp-molcell.bsky.social. We show that damage to nascent RNAs should not be ignored, and under certain conditions, these can turn into DNA breaks. We call this phenomena RDIBs (RNA Damage Induced Breaks). www.cell.com/molecular-ce...
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks
Tsao et al. uncover a novel pathway for genotoxicity, termed RNA-damage-induced DNA breaks (RDIBs). The mechanism for preventing RDIBs is orchestrated by YTHDC1 along with the THO complex, which funct...
cell.com
Rudolf the white nosed pancake, had a very shiny nose…
I am planning to make it through the #NIH freeze with some creative adult beverages. Any suggestions?!?
So tonight I'm going to sketch a plan about my next grant using worms as a model system.
If it wasn't clear already, I hope my first post here makes it clear what I do and love.
RNA Damage Responses in Cellular Homeostasis, Genome Stability, and Disease | Annual Reviews
All cells are exposed to chemicals that can damage their nucleic acids. Cells must protect these polymers because they code for key factors or complexes essential for life. Much of the work on nucleic...
annualreviews.org