Thrilled to share our latest work, led by @aryantaheri.bsky.social and Julia Peukes! Using cryo-EM and cryo-ET, we reveal how KIF21B’s distal tail engages multiple tubulin dimers along a protofilament, enabling persistent microtubule attachment and crosslinking. www.biorxiv.org/content/10.6...

Thrilled to share our collab led by Grace Hibshman with the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.

🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by Juan Perez-Bertoldi and Julie Dang spanning atoms to organisms. 1/n

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

Congrats to Ana Galic and Kevin Li, who just graduated with honors in MCB @berkeleymcb.bsky.social, and to the brand new Dr. Trinity Cookis @trinitycookis.bsky.social 👨‍🎓👩‍🎓👩‍🎓🤩. Very best wishes for your next endeavors 💝

Congrats to my @berkeleymcb.bsky.social colleague Andy Martin, who just received the Dorothy Crowfoot Hodgkin Award of the @proteinsociety.bsky.social. Andy's studies have made the proteasome one of the best understood molecular machines in biology. Well deserved!!

An honor to share the closing Keynote session @CellBio2025. Thank you American Society for Cell Biology (ASCB) and EMBO for an amazing meeting and for making us feel part of a community of inspiring scientists.

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social www.biorxiv.org/content/10.1...

Delighted to present my trajectory and research to audiences ranging from high school students to researchers at Hong Kong Universities and Science Centers. Special thanks to my local ambassadors Zhoe and Emi for making my visit so special 🥰🥰

An honor and pleasure to be at the @HKLaureatesForum, a “meeting of inspirational minds” gathering @ShawPrize recipients 🏅 and young scientists. Inspirational to hear other laureates and interact with promising researchers curious about the world around them, big 🪐 & small 🧬

Thrilled to share our new cryo-ET preprint on astrocytes, a collaboration with @mengmengfu.bsky.social here at @ucberkeleyofficial.bsky.social, revealing the nm-scale cytoskeletal architecture of ramified astrocytes reminiscing in vivo morphology. Check out the cytoskeleton compartmentalization!

Meng-meng Fu@mengmengfu.bsky.social · 10mo ago

Excited to share our preprint on cytoskeletal organization in astrocytes! biorxiv.org/content/10.110… Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes. Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓 1/x

A unique honor to become a Foreign Member of the @royalsociety.org, together with my @ucberkeleyofficial.bsky.social colleague Stuart Russell and old friends like John Briggs, Asia Akhtar, Patrick Cramer or Ruth Lehmann. Learning about great science and science history was a real treat.

Very grateful to the Menéndez Pelayo International University for awarding me an honorary doctorate last Tuesday, July 8th, in the incomparable setting of the Magdalena Palace (Santander). On Monday I enjoyed a conversation with those interested in my career and science.

Our work, co-led by @alfredo0712.bsky.social and @nlue8.bsky.social is out in @natsmb.nature.com Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and S. Kassube for their contributions and thanks to the reviewers for the suggestions that led to the final work. www.nature.com/articles/s41...

Structural insights into transcriptional regulation by the helicase RECQL5 - Nature Structural & Molecular Biology

Florez Ariza and Lue et al. use cryo-electron microscopy to investigate how the RECQL5 helicase regulates transcription. Their structural findings suggest that RECQL5 can modulate RNA polymerase II’s ...

nature.com

So proud of the smashing success of the International Course in Biophysics co-organized with my @berkeleymcb.bsky.social colleague Carlos Bustamante and University of Salamanca @usaloficial.bsky.social biophysal.org Course ends with a Keynote from Nobel Laureate Richard Henderson🥇

BioPhySAL - First Salamanca International Advanced Biophysics and Structural Biology Course

First Summer International Advanced Biophysics and Structural Biology Course. Eva Nogales - Carlos Bustamante.

biophysal.org

Yesterday I had the pleasure to visit the Institute for Material Science in Madrid @icmm-csic.bsky.social. Thank you to Dr. Pedro Serana for his invitation to talk about cryo-EM and our latest microtubule studies 🧩🔬🧬

I spent a wonderful day in the Universidad de Córdoba at an interactive breakfast with faculty and students and giving a science presentation. Lovely to meet its Chancellor, Manuel Torralbo, and my friend and past collaborator Prof. Tina Domínguez-Martín.

It was an absolute pleasure to visit the IBiS, to meet its scientists, interact with its students, and visit beautiful Sevilla 🥰

IBiS - Instituto de Biomedicina de Sevilla@ibis-investigacion.bsky.social · last yr.

🟠SCIENCE | Thank you very much to Prof. Eva Nogales for sharing her outstanding and inspiring science with us. It was an honor to host her at IBiS! @hhmi.org @unisevilla.bsky.social @csic.es @nogaleslab.bsky.social @csicandalextrem.bsky.social @ucberkeleyofficial.bsky.social

Excited to have participated in the Third Symposium of Physical Chemistry in the Universidad Autónoma de Madrid @uam.es last week and honored that the Prizes for best student talk and best posters carried my name 🥰☺️

Que día tan emocionante volver a mi colegio en Colmenar Viejo y recibir el calor de sus profesores y sus alumnos. Gracias por darle mi nombre a vuestra biblioteca! 🥰

Deeply touched and honored by the Universidad Autónoma de Madrid, my alma mater, (@uam.es) making me Doctor Honoris Causa. Thank you to the Department of Physical Chemistry for nominating me for this recognition. It was a memorable day for me and my family👩‍🎓

Like a dream, my name next to that of @isabelallende.com, and to be recognized by Universidad Internacional Menéndez Pelayo UIMP. Soon after, Irene Vallejo @irenevalmore.bsky.social will receive the same honor. I feel proud to be linked to these truly inspiring, talented women! Thank you UIMP!

This week our lab had a double celebration: 1) Eva’s election into the @royalsociety.org and 2) Zhenlin’s new job in Southern University of Science and Technology, China. He will be missed but we wish him success and joy in his independent career!

Check out our review article on the structural and functional studies of retrotransposon proteins by @akankshathawani.bsky.social together with Kathy Collins' lab. www.sciencedirect.com/science/arti...

Structural and biochemical studies of mobile retrotransposon proteins in action

Autonomous non-long-terminal repeat (non-LTR) retrotransposons, including long interspersed elements (LINEs), are mobile genetic elements abundant in …

sciencedirect.com

Check out our lab’s latest work on the regulation of transcription by RECQL5 helicase! This work was co-led by @alfredo0712.bsky.social and @nlue8.bsky.social, with contributions from Patricia Grob, Ben Kaeser, Jie Fang, and Susanne Kassube. 1/7 www.biorxiv.org/content/10.1...

Structural insights into transcriptional regulation by the helicase RECQL5

Transcription and its regulation pose a major challenge for genome stability. The helicase RECQL5 has been proposed as an important factor to help safeguard the genome, and is the only member of the h...

biorxiv.org

I encourage you to apply and join us at @ucberkeleyofficial.bsky.social !

Jim Hurley@jimhurley.bsky.social · 2y ago

Scientific Director, Cal-Cryo. We are looking for an outstanding microscopist to run our cryo-EM facility (two Krioses and an Arctica), increase training, engagement, and collaboration on campus, expand our user base, and join our community of cutting edge cryo-EM researchers. tinyurl.com/ykasna3p

Our microtubule team at lunch with @ruizhangmt.bsky.social, who gave a spectacular seminar at UC Berkeley on his work on axonemes

The Cryo-EM: the next 50 years Symposium held yesterday at @ucberkeleyofficial.bsky.social was a smashing success!!

Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription. www.nature.com/articles/s41...

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology

Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

nature.com

El #CSIC concede su Medalla Extraordinaria al Mérito Científico a la biofísica española Eva Nogales, pionera en el uso de criomicroscopía electrónica para visualizar funciones vitales de los componentes moleculares de las células del cuerpo. ¡Enhorabuena! https://bit.ly/4gsh3W7