🔥 New in this month's issue! 🤔 How does #intraarticular calcification from #calcium crystal deposition cause worsening cartilage damage and knee pain in #osteoarthritis? Find out more about in this study from Liew et al. - www.oarsijournal.com/article/S106...

🧠 Is #mentalhealth a mediator between nonsurgical interventions and pain and function in people with #OA 🔓 Read more for free in this month's issue from Richelle Caya et al. - www.oarsijournal.com/article/S106...

#Denosumab use was associated with a reduced risk of knee #osteoarthritis compared with bisphosphonates in adults with osteoporosis, Read more from Zhaohua Zhu et al. in this month's issue - www.oarsijournal.com/article/S106...

🦵 New in this month's issue! The prevalence of #varusthrust is 27% of individuals with knee osteoarthritis Prevalence also increases with greater structural OA severity and is higher in people with varus alignment. Read for free from Haonan Shen et al. - www.oarsijournal.com/article/S106...

#New #Basic #Science in #OAC This month Mohana-Borges et al. assessed the mysterious meniscus ossicle and their role in #knee OA. Read more: www.oarsijournal.com/article/S106... #Basic #Science in #OAC

August's Editors Choice (Clinical) is all about #ACI Snow et al investigated the long-term effects of #autologous chondrocyte implantation (ACI) and found it to be an effective option vs alternative forms of surgical cartilage management in the knee www.oarsijournal.com/article/S106...

New in #OAC! Fibroblast activation protein (FAP) is upregulated in #OA across species and drives fibroblast activation via mechanical signals. Blocking FAP restores healthier cell behavior offering a potential new therapeutic path to slow joint degeneration. 🔗 www.oarsijournal.com/article/S106...

Inhibition of fibroblast activation protein partially restores the homeostatic phenotype of mechanoactivated synoviocytes

Synovial fibrosis, characterized by mechanoactivation of fibroblast-like synoviocytes (FLS), is thought to be a driver of osteoarthritis (OA). Fibroblast activation protein (FAP) is expressed by activ...

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🛑⚠️ Dubious Paper Alert ⚠️🛑 Can you easily identify #fabricated #OA publications? youtu.be/ghAHsZhZzMc This master class with Dr. Ben Faber will help you identify dubious OA publications and how we might stop them!

Published examples of dubious osteoarthritis papers and how we might stop them - Dr Ben Faber

YouTube video by Joint Action

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New in #OAC. This work by Bhadouria et al. investigates the mechanisms of #osteoporosis drug raloxifene in the context of intervertebral #disc #degeneration associated lower back pain. Read more 🔗 : www.oarsijournal.com/article/S106...

Raloxifene injections normalize age-related mechanical sensitization in female and male mice and augment intervertebral disc structure in old female mice

Intervertebral disc (IVD) degeneration (IVDD) is a prevalent contributor to low back pain, yet IVDD-modifying therapeutics are unavailable. Osteoporosis drug raloxifene reduces age- and sex-related IV...

oarsijournal.com

New findings this month! CREB5 protects against intervertebral disc degeneration by inhibiting ferroptosis and mitochondrial oxidative stress via the NR4A1–PGC-1α axis. A novel therapeutic target for IDD! #Ferroptosis #IDD #Mitochondria #CREB5 Read more🔗: www.sciencedirect.com/science/arti...

New in #OAC! Heluany et al. identified miR-544a-3p as a new, important modulator of the Wnt signalling network within the articular cartilage! Read more to determine how miR-544a-3p modulates cartilage homeostasis! 🔗: www.sciencedirect.com/science/arti...

CRTAC1 is a promising biomarker for osteoarthritis: its levels are elevated in plasma and synovial fluid, correlate with #OA severity and inflammation, and are linked to miRNAs regulating disease progression. #Osteoarthritis #biomarker Read more 🔗: sciencedirect.com/science/arti...

New in this month's issue 👀 🚶‍♀️ Pathological hypoxia of the medial aspect of the tibial tuberosity during walking appears specific to patients with knee #osteoarthritis BMLs Read for free from Nakanishi et al. - www.oarsijournal.com/article/S106...

Tibial hemodynamics during walking in knee osteoarthritis with bone marrow lesions: A cross-sectional study

Impaired subchondral bone perfusion contributes to bone marrow lesions (BMLs) in knee osteoarthritis (KOA); however, it has been assessed only under static and non-weight-bearing conditions. Dynamic, ...

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🧘 Yoga and osteoarthritis Yoga was associated with lower societal costs and slightly higher QALYs compared to strength training for knee #osteoarthritis Read more from Bedru Jemal Abafita and colleagues in this month's issue - www.oarsijournal.com/article/S106...

🔥 New this month about #metformin 💊 10 year cumulative #osteoarthritis incidence in metformin initiators were 3% lower than non-initiators Read more from Magnusson et al. - www.oarsijournal.com/article/S106...

🤔 Are clinical guidelines for knee osteoarthritis failing the global population? This months Editors Choice (Clinical) looked at 241 RCTs to reveal some blind spots Read for free from Low et al. - www.oarsijournal.com/article/S106...

New in #OAC Cartilage breakdown in #OA is driven by proteinases. Wilkinson et al. stresses that understanding and measuring proteinase activity - or historical evidence of activity - should be an important consideration in basic OA research. Read more 🔗: sciencedirect.com/science/arti...

New study by Woods et al. develops a human pluripotent stem cell model to study growth plate development and uncover pathogenic mechanisms in a rare cartilage disease. #PluripotentStemCells #DiseaseModel #Cartilage Read more 🔗: www.oarsijournal.com/article/S106...

Human pluripotent stem cell model of multiple epiphyseal dysplasia with MATN3 mutation identifies altered matrix organisation and upregulation of the cholesterol biosynthesis pathway

Multiple epiphyseal dysplasia (MED), caused by mutations in MATN3, is a chondrodysplasia affecting the cartilage growth plate and is characterised by delayed epiphyseal ossification, short stature, an...

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#New in #OAC Cartilage shear strain measured by MRI 6 months after ACL reconstruction distinguishes symptomatic from asymptomatic knees—offering a potential early marker of osteoarthritis risk. #MRI #ACL #osteoarthritis #biomechanics Read more 🔗: www.oarsijournal.com/article/S106...

In vivo cartilage strain differentiates symptomatic, asymptomatic, and healthy knees six months after ACL reconstruction

Alterations in cartilage mechanical properties may signal early degenerative changes preceding clinical or radiographic evidence of osteoarthritis. MRI-based techniques may detect these early pre-oste...

oarsijournal.com

🚀 OAC is on the rise! The 2025 Journal Impact Factors just dropped and OAC continues to be one of the top journal destinations for our community. Huge congratulations and thanks to our dedicated editors, authors, reviewers, and staff! Let's keep the momentum going. 📈

How does silencing Linc01152 increase SOX9 expression?🧐 Check out this new work in #OAC byMai et al. www.oarsijournal.com/article/S106...

Silence of Linc01152 promotes chondrogenic differentiation and facilitates cartilage repair through directly increasing SOX9 expression

The long intergenic non-coding RNA Linc01152 is a recently identified lncRNA whose functional involvement in osteoarthritis (OA) remains largely understood. In the present study, we tried to elucidate...

oarsijournal.com

New in #OAC! A new high throughput screen of #FDA approved compounds finds the MEK inhibitor trametinib as a promising compound for drug repurposing for osteoarthritis disease modification. Read more 📚: www.oarsijournal.com/article/S106...

🤔 How can reviewers better identify dubious papers in this age of #AI #LLMs? In this short presentation first given at the recent OARSI conference, Ben Faber MD PhD presents published examples and how best to manage them 👇 👇 👇 youtu.be/ghAHsZhZzMc?...

Published examples of dubious osteoarthritis papers and how we might stop them - Dr Ben Faber

YouTube video by Joint Action

youtu.be

Did you know bile acids (BA) might influence joint health? The presence of BA receptors in synovial tissue, along with detectable BAs in synovial fluid and their impact on synovial cells, suggests a unique biological role for BAs in joint inflammation. oarsijournal.com/article/S106...

👀 Must read in this month's issue on new early imaging biomarkers of osteoarthritis Read for free by Gareth Jones et al. - www.oarsijournal.com/article/S106...

🔥 Just out! The first of OAC's Osteoarthritis "Fundamental series" covers #diagnosis and #assessment A clinician’s diagnosis is a vital step to facilitate access to and engagement with treatment. Read more from Lauren King and Abhishek Abhishek here: oarsijournal.com/article/S106...

📈Knee arthroplasty in OECD countries has hit a tipping point New study by Backes, Pabinger, Lothaller & Geissler tracked 25 countries over 17 years and found that patients under 65 now make up >50% of all procedures - up from ~37% in 2005. Read for free: www.oarsijournal.com/article/S106...

#New this month our #Basic #Science Editor's Choice for #June. PAR2 in bone accelerates late-stage OA, showing bone turnover’s key role in joint damage and the age- and cell-specific complexity of PAR2. #Osteoarthritis #BoneHealth Read more 🔗: www.sciencedirect.com/science/arti...

The @oacjournal.bsky.social special issue on clinical trials is out! www.oarsijournal.com/current. there is some really important work here (mine included 😉) on responder analyses, trial endpoints, prognostic enrichment, smallest worthwhile effects/clinical relevance (& power implications).

🦴Is waiting for knee replacements (TKR) slowing down drug discovery? Using intermediate endpoints might make trials faster: 🔹CKOASO: Cuts sample size from 3,000 to 229 🔹esKOA: Strongest predictor of future TKR (5.7RR) 🔹FNIH: High feasibility doi.org/q5p8