Our latest preprint continues our investigations into spinal mechanisms of human chronic pain! We find no evidence for a loss of neurons in the dorsal horn of donors with chronic lower limb pain, and the ratio of excitatory to inhibitory interneurons also remains consistent between pain states.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 4w ago

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn https://www.biorxiv.org/content/10.64898/2026.09.15.751829v1

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

biorxiv.org

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social www.biorxiv.org/content/10.1...

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

biorxiv.org

Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. I’ll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience! @tedpricethepainguy.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Decreased KCC2 expression in the human spinal dorsal horn... : PAIN

date there is no evidence supporting or opposing this hypothesis in humans. Here, we demonstrate that KCC2 expression is decreased in superficial dorsal horn neurons of organ donors who died with a do...

journals.lww.com

Highly, highly recommend working with Andy and the Spinal Cord Group!

Andy Bell@belllab.bsky.social · last yr.

Are you interested in omics approaches to pain and projection neurons? Why not join us? We’ve got a post-doc position available. Happy to discuss further with anyone who is interested. www.jobs.gla.ac.uk/job/research... #neuroskyence #neurosci #PainResearch

Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry https://www.biorxiv.org/content/10.1101/2025.04.07.647666v1

Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use

Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...

biorxiv.org