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OrianRousseauLab

@orianrousseaulab.bsky.social

Our Lab is studying tumor growth and metastasis. We focus on gastro-intestinal cancers but are also highly interested in various types of leukaemia. We make extensive use of organoids. Homepage: https://fms.ibcs.kit.edu/orian-rousseau.php

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OrianRousseauLab@orianrousseaulab.bsky.social · 6d ago

🎉 Our new paper is out in Cell Death & Disease! We show that CD44 in pancreatic CAFs links ECM remodeling to immunosuppression. Loss of CD44 reduces fibrosis and Tregs, limits CAF-driven immunosuppression and improves T-cell killing. www.nature.com/articles/s41... #PDAC #CD44 #CAFs #TumorImmunology

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions - Cell Death & Disease

Cell Death & Disease - Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions

nature.com

OrianRousseauLab@orianrousseaulab.bsky.social · 4w ago

Upper Rhine Immunology Meeting 2026! 23.10.2026, KIT Karlsruhe: Invited speakers: T. Cathomen (Freiburg):Will CRISPR Cure Immunological Disorders? Lessons from a Mouse Model of Hyperinflammation. F. Andreata (Milan)The Tissue Logic of Immune Surveillance: Lessons from the Liver.Deadline: 31.7.2026

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OrianRousseauLab@orianrousseaulab.bsky.social · 2mo ago

www.linkedin.com/posts/v%C3%A...

Registration is now open for the Upper Rhine Immunology Meeting (URI) 2026, bringing together researchers from the Karlsruhe Institute of Technology, University of Strasbourg, University of Basel… | V...

Registration is now open for the Upper Rhine Immunology Meeting (URI) 2026, bringing together researchers from the Karlsruhe Institute of Technology, University of Strasbourg, University of Basel, and...

linkedin.com

OrianRousseauLab@orianrousseaulab.bsky.social · 4mo ago

Fantastic time at the Annual Meeting of the German Society for Matrix Biology!Thanks to the organisers. Congrats to Dr. Julie Martin for the poster prize on the contribution of CD44 on Cancer Associated fibroblasts in pancreatic cancer. Great talks, and a dinner at the Heidelberg Castle.

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OrianRousseauLab@orianrousseaulab.bsky.social · 9mo ago

Our new preprint shows CD44 as a key regulator of CAF activation, controlling the desmoplastic stroma and shaping the immunosuppressive microenvironment in pancreatic cancer. Congrats to my team and our fantastic collaborators from UniClinic Freiburg and TRON www.biorxiv.org/content/10.6...

Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions

Pancreatic tumors are characterized by a prominent stroma that makes up to 90% of the tumor. Due to the significant upregulation of CD44, a family of transmembrane glycoproteins, in pancreatic cancer-...

biorxiv.org

OrianRousseauLab@orianrousseaulab.bsky.social · 9mo ago

www.linkedin.com/posts/v%C3%A...

The “Nacht der Wissenschaft” was organized by a dedicated team of KIT students and took place on 21.11.25. It was an unusual experience to give a talk on cancer/organoids/assembloids at 2:00 am and… |...

The “Nacht der Wissenschaft” was organized by a dedicated team of KIT students and took place on 21.11.25. It was an unusual experience to give a talk on cancer/organoids/assembloids at 2:00 am and st...

linkedin.com

OrianRousseauLab@orianrousseaulab.bsky.social · 12mo ago

CD44 in Group 1 Innate Lymphoid Cells Impacts the Development and Progression of Steatohepatitis - Bourinet - 2025 - Liver International - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/... Congratulations to the groups of P. Gual and C. Luci. Thanks for involving us in this work

CD44 in Group 1 Innate Lymphoid Cells Impacts the Development and Progression of Steatohepatitis

Background and Aims Innate lymphoid cells (ILCs) play pivotal roles in inflammation and fibrosis, which are key features of chronic liver diseases. The contribution of group 1 ILCs, including natura...

onlinelibrary.wiley.com

OrianRousseauLab@orianrousseaulab.bsky.social · last yr.

Here is our new paper on pancreatic cancer metastasis. Using a mouse model, we show that removing Cd44/Cd44v6 in bone marrow–derived cells disrupts the metastatic niche and, as a result, reduces pancreatic cancer metastasis #CD44 #pancreatic cancer #metastatic niche www.biorxiv.org/content/10.1...

Reprogramming Immunosuppressive Bone Marrow Derived Cells via CD44 Targeting Impacts Pancreatic Cancer Metastasis

Pancreatic ductal adenocarcinoma (PDAC) is characterized by early dissemination and an aggressive metastatic course. In order to establish in the liver, metastatic cells require a metastatic niche pro...

biorxiv.org

OrianRousseauLab@orianrousseaulab.bsky.social · last yr.

G. Laverny and V. Orian-Rousseau share with you their project funded by the canceropole EST. This is the first step of the growing collaboration between the GenomEast platform (IGBMC) and the Organoid Research Centre (KIT, IBCS-FMS) hashtag#KIT hashtag#UNISTRA hashtag#igbmc hashtag#organoids

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OrianRousseauLab@orianrousseaulab.bsky.social · 2y ago

Check out this paper from the group of Philippe Gual, INSERM U1065, Nice, France. Our Cd44 floxed mice were used in this study on alcohol-related liver diseases (ALD). Many thanks to Philippe Gual for a very successful collaboration

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OrianRousseauLab@orianrousseaulab.bsky.social · 2y ago

Congratulations to Dr Sven Treffert for his excellent PhD defence on CD44 as a key player in Radiotherapy resistance, fibrosis and immune escape in pancreatic cancer. We think the Wilhelm Sander-Stiftung for the support @sander stiftung

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