Carvajal-Zamorano et al. find that zoledronic acid inhibits TRPV1 function, reduces nociceptive responses in preclinical models, and reveals a mechanistic basis for analgesia with potential clinical repurposing. Learn more in #PainReports bit.ly/4hYl8Vs
PAIN Reports
@painreports.bsky.social
PAIN Reports is an official publication of the International Association for the Study of Pain (IASP). An open access multidisciplinary journal, PAIN Reports promotes a readily accessible forum that advances research on pain.
Tremblais et al. assessed the effects of a lack of control on pain perception and learning and found that experiencing uncontrollable pain leads to lower perceived pain and relief pleasantness. Learn more in #PainReports bit.ly/4aaXuRi
Li et al. developed a new single-session preventive psychological intervention targeting pain after surgery entirely based on experiences of patients and caregivers. Learn more in #PainReports bit.ly/4fFeuCU
Kaur et al. present a comprehensive synthesis of the findings from 29 studies on spinal cord stimulation. The results could serve as a valuable contribution in the spinal cord stimulation patient selection process. Learn more in #PainReports bit.ly/4dIKJ1n
Bradt et al. review use of electroencephalography globally to measure acute neonatal pain, initiate collaborations with key researchers in the field, and identify data for subsequent meta-analysis. Learn more in #PainReports bit.ly/4dOkIhh
Start learning before Bangkok with recorded #IASP2026 Refresher Courses on pain research, clinical practice, policy & education.~$29/course for IASP members; $49 for non-members. Separate PERC registration: bit.ly/46tW02C #PainEducation
Di Domenico et al find that childhood discrimination is associated w/ higher multisite pain odds across multiple discrimination subtypes, revealing dose-dependent relationship independent of socioeconomic factors, adverse childhood experiences #PainReports bit.ly/4fbfHlk
Pain Awareness Month Week 4: ADVANCE. Turn awareness into action through learning, collaboration & evidence sharing. Explore IASP's resources and share how you are advancing pain research, education or care: bit.ly/4zSCeLB #PainAwarenessMonth #IASP2026
In their 2-cohort analysis, Jaltare et al. find that women with painful diabetic neuropathy have higher pain, anxiety, sleep disturbance, and worse small-fiber dysfunction compared with men. Learn more in #PainReports bit.ly/3PMrcVN
Cheng et al. discuss motor deficit as a rare yet severe herpes zoster complication, more often diagnosed in men, characterized by a sensory loss phenotype and a poor prognosis. Learn more in #PainReports bit.ly/4u1UvC1
Bi et al. find that sleep disturbances and negative mood swings the day before an assessment can have a significant influence on ratings of perceived change the day after. Learn more in #PainReports bit.ly/3RPYBzD
Garcia et al. find that patients with facial pain disorders exhibited a heightened risk of suicide that was associated with considerable pain-related impairments. Learn more in #PainReports bit.ly/3PMrcoL
Mesaroli et al. used advanced diffusion MRI to identify increased anisotropy and reduced orientation dispersion in sensorimotor projection fibers in chronic low back pain, implicating altered neurite architecture. Learn more in #PainReports bit.ly/4vajjIR
Pontiff et al. find that higher estimated cardiorespiratory fitness is associated with lower odds of chronic pain and with more favorable changes in pain severity in the general population. Learn more in #PainReports bit.ly/4favaSH
Mouatt et al. find that sleep heart rate is positively associated with analgesic prescription in Veterans, suggesting that lowering basal autonomic arousal may reduce analgesic use. Learn more in #PainReports bit.ly/3PMrbkH
De La Rosa et al. present the Complex Regional Pain Syndrome Severity Score-Self Report, the first validated self-report measure of CRPS symptoms; it is accurate for tracking CRPS symptoms and diagnostic screening. Learn more in #PainReports bit.ly/4dPtHi8
Chen et al. find that despite overall hyposensitivity, there are race- and age-related differences in the relationships between clinical and laboratory-based pain among former professional American-style football players. Learn more in #PainReports bit.ly/3PMrax9
Singh et al.’s case report quantifies the effect of stellate ganglion blockade on atopic airway disease, with a mechanistic review highlighting this as a potential immunomodulatory adjunct. Learn more in #PainReports bit.ly/4f6NV9u
Chrétien et al. find that whole-body vibration diminished mechanical hypersensitivity, restored limb use, and reduced cartilage damage in male and female mice with knee osteoarthritis, supporting its therapeutic potential. Learn more in #PainReports bit.ly/3PMra07
Williams et al. find that methylglyoxal sex-dependently alters C-fiber activity-dependent slowing, potentially influencing spinal processing of noxious heat to drive heat hyperalgesia in males only. Learn more in #PainReports bit.ly/3PMr9JB
Montmeat et al. find that monoclonal antibody inhibition of PAR2 reduces murine colitis visceral hypersensitivity, pain-related behaviors, and phenotype severity. Learn more in #PainReports bit.ly/4dPcjKD
Among 1,153 surgical patients, Garduño-López et al. report that 84% recovered by 1 month, and 16% reported pain and interference. Chronic pain history and thoracic/orthopedic surgery predicted risk, supporting early detection. Learn more in #PainReports bit.ly/4q4ZPUH
Campbell et al. find that patients with facial pain disorders exhibited a heightened risk of suicide that was associated with considerable pain-related impairments. Learn more in #PainReports bit.ly/3PMrcoL
Bertoch et al. find that KLS-2031, a novel gene therapy for neuropathic pain, demonstrated a favorable safety profile and tolerability. Further studies are needed to confirm its safety and efficacy. Learn more in #PainReports bit.ly/3PoNiOg
@mahabermann.bsky.social et al. find that experiencing uncontrollable pain leads to lower perceived pain and relief pleasantness in a between-group design. Learn more in #PainReports bit.ly/4aaXuRi
In their 2-cohort analysis, Sloan et al. find that women with painful diabetic neuropathy have higher pain, anxiety, sleep disturbance, and worse small-fiber dysfunction compared with men. Learn more in #PainReports bit.ly/3PMrcVN
Hochreuter et al. developed the content of a new single-session intervention targeting pain after surgery entirely based on experiences of patients and parents. Learn more in #PainReports bit.ly/4fFeuCU
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Adriaansen et al. find that motor deficit is a rare yet severe herpes zoster complication, more often diagnosed in men, characterized by a sensory loss phenotype and a poor prognosis. Learn more in #PainReports bit.ly/4u1UvC1
Two #WC2026 workshops examine placebo/nocebo mechanisms, featuring @christianbuchel.bsky.social and @ulrikebingel.bsky.social. Register: bit.ly/4qx0aOI
Temp et al. find that whole-body vibration diminished mechanical hypersensitivity, restored limb use, and reduced cartilage damage in male and female mice with knee osteoarthritis, supporting its therapeutic potential. Learn more in #PainReports bit.ly/3PMra07