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Pajtler Lab

@pajtlerlab.bsky.social

Working on Reverse Translation and Adolescent & Young Adult Cancer at the Hopp Children's Cancer Center Heidelberg

10 Posts43 Follower 56 Folgt

Pajtler Lab @pajtlerlab.bsky.social · 4mo ago

Thrilled to share our latest work on the blood–brain barrier in ependymoma! Our data suggest the BBB remains largely intact — challenging assumptions about drug access. Read more: www.nature.com/articles/s41... #Ependymoma #BBB #BrainTumors

Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach - Scientific Reports

A significant obstacle in treating brain tumors is the limited drug penetration across the blood-brain barrier (BBB), characterized by an interplay of endothelial tight junctions and efflux pumps. Bra...

nature.com

Pajtler Lab @pajtlerlab.bsky.social · 6mo ago

Excited to share our latest work—establishing a pipeline for DNA methylation–based CNS tumor diagnostics from minimally invasive CSF liquid biopsies—published today in Nature Cancer! Huge thanks to all collaborators. www.nature.com/articles/s43... #LiquidBiopsy #PediatricNeuroOncology #TeamScience

M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors - Nature Cancer

Smith et al. present M-PACT, a deep neural network leveraging low-input cell-free DNA methylation profiles to achieve robust classification of pediatric brain tumors and enable cellular deconvolution ...

nature.com

Pajtler Lab @pajtlerlab.bsky.social · 11mo ago

#teamkitzheidelberg ran for connor! www.connorsrun.com/fundraisers/... #connorsrun #braintumorcharity #honortoconnor

Pajtler Lab @pajtlerlab.bsky.social · 12mo ago

Support Connor's Run and #teamkitzheidelberg to raise awareness for childhood brain cancers, especially Ependymoma! www.connorsrun.com/fundraisers/... #connorsrun #braintumorcharity #honortoconnor

Connor's Run 2025 - All of September

Your support means we can continue to fund critical research projects, improved testing, in-home care and clinical trials, to help change the odds for kids with brain cancer.

connorsrun.com

Pajtler Lab @pajtlerlab.bsky.social · last yr.

We are excited to share our latest work highlighting the potential of liquid biopsies for pediatric CNS tumor patients - just published in Acta Neuropathologica Communications! Thank you to everyone who contributed to this study! doi.org/10.1186/s404... #LiquidBiopsy #cfDNA #PediatricNeuroOncology

Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort - Acta Neuropathologica Communications

Molecular profiling of pediatric central nervous system (CNS) tumors has important clinical utility for guiding diagnostic and therapeutic strategies. Cell-free DNA (cfDNA) from liquid biopsies has be...

doi.org

Pajtler Lab @pajtlerlab.bsky.social · last yr.

We had the privilege of presenting at this year’s Pediatric Neuro-Oncology Conference in San Diego. It was great to share our research and connect with friends and future collaborators dedicated to improving outcomes for children with brain tumors. #PediatricNeuroOncology #TeamScience #SNOPeds2025

Pajtler Lab @pajtlerlab.bsky.social · last yr.

Thanks to the #Eureka Institute and @sickkidsto.bsky.social for hosting an amazing Translational Medicine Course and turning Tom Fischer and Leonhard Bamberg into newly baked #Eurekans! Loved it in Toronto!

Pajtler Lab @pajtlerlab.bsky.social · last yr.

Paper on the challenges of hydrophobic drugs in cerebral microdialysis accepted to #CTSJournal, #ASCPTJournalFamily Based on own data + intensive literature review, we developed a decision tree to guide future studies in testing unspecific binding prior to microdialysis: doi.org/10.1111/cts....

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates

Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simu...

doi.org