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Papalopulu Lab

@papalopululab.bsky.social

Interested in how changes in gene expression dynamics underlie cell state transitions in development and cancer. Our team is led by Prof Nancy Papalopulu and we are based at the University of Manchester.

21 Posts97 Follower99 Folgt
Development@dev-journal.bsky.social · 3mo ago

Read the Research Article 'Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif' here. journals.biologists.com/dev/article/...

Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif

Highlighted Article: Expression of the cross-repressing proteins HES1 and HES5 is mutually exclusive but when they oscillate, a cell can express both, creating a hybrid state that later resolves into…

journals.biologists.com

Papalopulu Lab@papalopululab.bsky.social · 6mo ago

Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...

HES1 oscillations are required for cell cycle reentry in oestrogen receptor–positive breast cancer cells | PNAS

Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumor cells (DTCs) and remains a major clinical challenge, ...

pnas.org

Papalopulu Lab@papalopululab.bsky.social · 11mo ago

Looking for a PhD? Don't miss this opportunity to work with @anzymiller.bsky.social @lovegrovelab.bsky.social Karel Dorey and @veronicabiga.bsky.social. The deadline is Nov 8th! www.findaphd.com/phds/project...

(MRC DTP) The impact of cell division on the decoding of oscillatory protein expression during spinal cord development and regeneration at The University of Manchester on FindAPhD.com

PhD Project - (MRC DTP) The impact of cell division on the decoding of oscillatory protein expression during spinal cord development and regeneration at The University of Manchester, listed on FindAPh...

findaphd.com

the Node@the-node.bsky.social · 12mo ago

ICYMI, the recordings of our #DevPres webinar on gene regulation are now available. Check out the talks from @dev-journal.bsky.social PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social. thenode.biologists.com/catch-up-on-... #devbio 🎥

Catch up on Development presents… webinar on gene regulation - the Node

Catch up on the Development presents... gene regulation webinar, featuring talks from two of Development's PI fellows.

thenode.biologists.com

Papalopulu Lab@papalopululab.bsky.social · 11mo ago

Check out the Perspective piece by our colleague @anzymiller.bsky.social and other fellows on the Pathway to Independence programme!

Anzy Miller@anzymiller.bsky.social · 11mo ago

If you want to know why we should care about protein expression dynamics have a read of the perspective piece I wrote for @dev-journal.bsky.social. While you're there check out my fellow Pathway to Independence fellows' interesting pieces! journals.biologists.com/dev/article/...

Papalopulu Lab@papalopululab.bsky.social · last yr.

This exciting study led by @anzymiller.bsky.social is now published! NGN3 oscillations control the timing of differentiation during pancreas development through a fold-change sensitive gene regulatory motif. Congratulations to all authors!

Anzy Miller@anzymiller.bsky.social · last yr.

I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004

Papalopulu Lab@papalopululab.bsky.social · last yr.

In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”: www.biorxiv.org/content/10.1...

Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif

Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, ev...

biorxiv.org

Papalopulu Lab@papalopululab.bsky.social · last yr.

We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...

PI programme | Development | The Company of Biologists

PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...

journals.biologists.com