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A 2023 German psychiatric study found that playing Super Mario Odyssey significantly improved depressive symptoms in clinically depressed individuals compared to regular psychotherapeutic treatment, reducing depression by 43%.

Effects of a video game intervention on symptoms, training motivation, and visuo-spatial memory in depression
By Moritz Bergmann, Ines Wollbrandt, Lisa Gittel, Eva Halbe, Sarah Mackert, Alexandra Philipsen, Silke Lux Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany, 2023
doi.org/10.3389/fpsyt.2023.1173652
Methods: a total of 46 clinically depressed individuals were treatment including psychotherapy and/or randomly assigned to one of three groups: an experimental "3D video gaming" group (n = 14) which played Super Mario Odyssey, an active control group (n = 16) which trained with a computer program "CogPack," and a treatment-as-usual (TAU) group (n = 16) which received a standard clinical pharmacotherapy.
Results: regarding depressive symptoms, a significant decrease in the proportion of participants who showed clinical levels of depressive symptoms as measured by the Beck Depression Inventory was only found in the 3D video gaming group (which played Super Mario Odyssey).
Conclusion: besides a standalone cognitive training, the current findings suggest that cognitive trainings using a video game have potential to increase subjective well-being, show higher levels of training motivation, and lead to improvements in visuo-spatial memory functions in MDD.
The proportion of participants that showed depressive symptoms (BDI-II ≥ 13) at pre- (T1) and post-assessment (T2). For Super Mario Odyssey, 100 at T1 and 57 at T2.
Note: information heavily abridged. For the full paper, see link above.