In an analysis from the Nudge study, the per-patient cost of text message reminders suggests that medication adherence support via mobile messaging may be a low-cost solution for healthcare systems. Learn more ➡️ du.ke/pctnews20260...

September 3, 2026: Text Message Medication Reminders Were Low-Cost Intervention in Nudge Study - Rethinking Clinical Trials

Text message reminders to support cardiovascular medication adherence can be a low-cost tool for participating healthcare systems, according to a recent analysis from the Nudge study. The report was p...

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ICYMI Registration is now open for our virtual workshop, "Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes." #biostatistics #pragmatictrials #clinicalresearch duke.is/2026-nih-vir...

August 17, 2026: Registration Open for NIH Collaboratory Virtual Workshop on Endpoint Strategies and Meaningful Outcomes - Rethinking Clinical Trials

The NIH Pragmatic Trials Collaboratory will hold a virtual workshop on September 8 and 9, 2026, on “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes.” The workshop […]

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Viewpoint discusses the challenges of implementing findings from pragmatic clinical trials in health care systems. https://ja.ma/4gvoewT

📣 In this week's PCT Grand Rounds, Haider Warraich of @arpa-h.bsky.social will present “Evaluating Clinical Agentic AI.” Join us! 🔗 duke.is/pctnews20260...

A new article from NOHARM, an NIH Collaboratory Trial, describes strategies and challenges for posttrial sustainment of pragmatic trial interventions. duke.is/pctnews20260...

How can clinical trials become more efficient without compromising rigor? Alison Huang and Derek Angus discuss JAMA+ Trials and opportunities to share innovations that reduce complexity and improve how trials are designed and conducted. Listen below.

NIH Pragmatic Trials Collaboratory@pctcollaboratory.bsky.social · 2w ago

In a new episode of the NIH Collaboratory Podcast, Alison Huang and Derek Angus consider the potential of JAMA+ Trials as a platform and a forum. 🔗 Listen and subscribe: duke.is/pctpod

The LungSMART team has proposed a framework for assessing the fit of custom large language models in public health interventions. The framework can guide assessments of an LLM’s performance before deployment into real-world practice. Learn more ➡️ duke.is/pctnews20260....

August 20, 2026: LungSMART Team Proposes Framework for Assessing Fit of Large Language Models in Public Health Interventions - Rethinking Clinical Trials

Using the interactive text messaging intervention from the LungSMART trial as a case study, researchers demonstrated the application of a proposed framework for assessing the fit of custom large langu...

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📣 In this week's PCT Grand Rounds, Eric Karl Oermann of NYU Langone Health and New York University will present “Off-Label Intelligence: Books, Language Models, and AI as a Medical Device.” Join us! 🔗 duke.is/pctnews20260...

In a new episode of the NIH Collaboratory Podcast, Alison Huang and Derek Angus consider the potential of JAMA+ Trials as a platform and a forum. 🔗 Listen and subscribe: duke.is/pctpod

ICYMI Registration is now open for our virtual workshop, "Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes." #biostatistics #pragmatictrials #clinicalresearch duke.is/2026-nih-vir...

August 17, 2026: Registration Open for NIH Collaboratory Virtual Workshop on Endpoint Strategies and Meaningful Outcomes - Rethinking Clinical Trials

The NIH Pragmatic Trials Collaboratory will hold a virtual workshop on September 8 and 9, 2026, on “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes.” The workshop […]

duke.is

📣 In this week's PCT Grand Rounds, Christopher Lindsell, Lloyd Michener, @justinbmoorephd.bsky.social, Boris Volkov, and Reuben Adatorwovor will present “Designing for Impact: Introducing Translational Design Studies.” Join us! 🔗 duke.is/pctnews20260...

We recently spoke with investigators Rachel Winer, Amanda Petrik, and Jasmin Tiro about the the STEP-2 pragmatic trial's partnership with community health centers and Medicaid health plans to expand access to #HPV self-testing for cervical cancer. duke.is/pctnews20260...

August 11, 2026: Updates From the STEP-2 Trial: An Interview With Rachel Winer, Amanda Petrik, and Jasmin Tiro - Rethinking Clinical Trials

STEP-2, an NIH Collaboratory Trial, will evaluate the comparative effectiveness and cost-effectiveness of in-clinic vs mailed distribution of human papillomavirus (HPV) self-sampling kits to improve c...

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In a new article in JAMIA Open, investigators from the NIH Collaboratory Trials report on their experiences using computable phenotypes with real-world data in pragmatic trials. Learn more ➡️ duke.is/pctnews20260...

August 10, 2026: NIH Collaboratory Trials Offer Lessons in Using Computable Phenotypes With Real-World Data - Rethinking Clinical Trials

Members of the NIH Pragmatic Trials Collaboratory’s Electronic Health Records (EHR) Core Working Group recorded the experiences of pragmatic trial investigators in using computable phenotypes in their...

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A secondary analysis from the INSPIRE trials found that an antibiotic stewardship program with automated prompts to deliver patient-specific risk information to clinicians reduced unnecessary use of extended-spectrum antibiotics in patients with cancer. duke.is/pctnews20260...

August 6, 2026: INSPIRE Trial's Reduction in Unnecessary Antibiotic Use Extends to Patients With Cancer - Rethinking Clinical Trials

In a secondary analysis of data from the INSPIRE trials, an antibiotic stewardship program that included automated prompts to deliver patient-specific risk information to clinicians led to significant...

duke.is

📣 In this week's PCT Grand Rounds, Sreek Vemulapalli of @dukehealth.bsky.social and Ricardo Henao of @duke-university.bsky.social will present “ADAPT-CEC: AI for Clinical Event Adjudication and Implications for Clinical Trials.” Join us! 🔗 duke.is/pctnews20260...

In a qualitative study, the APA-SM team gained insights from research partners in rural areas to refine the trial's smartphone-based intervention for self-management of chronic musculoskeletal pain. #ruralhealth #NIHHEALinitiative duke.is/pctnews20260...

August 3, 2026: APA-SM Team Consults Rural Research Partners to Refine Study Intervention - Rethinking Clinical Trials

In a qualitative study, the APA-SM team gained insights from research partners in rural areas to inform refinements of the trial’s smartphone-based intervention for self-management of chronic musculos...

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Join @pctcollaboratory.bsky.social for a virtual workshop, “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes” on September 8 and 9. Learn more: duke.is/2026-nih-vir... #pragmatictrials

July 27, 2026: NIH Pragmatic Trials Collaboratory Will Hold Virtual Workshop on Endpoint Strategies and Meaningful Outcomes - Rethinking Clinical Trials

The NIH Pragmatic Trials Collaboratory will hold a virtual workshop on September 8 and 9, 2026, on “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes.” The workshop […]

duke.is

Pragmatic clinical trials require statistical methods that reflect the complexities of real-world research. This NIH Pragmatic Trials Collaboratory workshop explores key biostatistical considerations for generating rigorous evidence that can inform clinical care.

NIH Pragmatic Trials Collaboratory@pctcollaboratory.bsky.social · last mo.

Join us for our 2026 virtual workshop, “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes” on September 8 and 9. Registration is free and open to the public. ➡️ Learn more: duke.is/2026-nih-vir... #biostatistics #pragmatictrials #clinicalresearch

🎙️ In a new episode of the NIH Collaboratory Podcast, Steven George and Christine Goertz of @dukemedschool.bsky.social discuss slow recruitment mitigation strategies, one of the small group discussion topics at the Steering Committee meeting in April. 🔗 Listen and subscribe: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Steven Z. George and @nickihastings.bsky.social of @dukemedschool.bsky.social will present results and reflections from the AIM-Back cluster randomized clinical trial. Join us! 🔗 duke.is/pctnews20260...

Join us for our 2026 virtual workshop, “Endpoint Strategy in Pragmatic Trials: From Big Questions to Meaningful Outcomes” on September 8 and 9. Registration is free and open to the public. ➡️ Learn more: duke.is/2026-nih-vir... #biostatistics #pragmatictrials #clinicalresearch

📣 In this week's PCT Grand Rounds, Rachel Greenberg and Danny Benjamin of @duke-university.bsky.social will present “The Pediatric Trials Network: Innovating to Make Drugs Safe and Effective for Children.” Join us! 🔗 duke.is/pctnews20260...

📣 In this week's PCT Grand Rounds, Ary Serpa Neto of @monashuniversity.bsky.social and Austin Health will present “Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit.” Join us! 🔗 duke.is/pctnews20260...

DCRI is proud to partner with the NIH Collaboratory to advance pragmatic clinical trials. In the latest #RethinkingClinicalTrials podcast, Duke's Brad Hammill, MS, and Keith Marsolo, PhD, discuss using death as an endpoint in pragmatic clinical trials.

NIH Pragmatic Trials Collaboratory@pctcollaboratory.bsky.social · 2mo ago

🎙️ In a new episode of the NIH Collaboratory Podcast, Brad Hammill and Keith Marsolo of @dukemedschool.bsky.social discuss the challenges and methods associated with the use of death as an endpoint in pragmatic clinical trials. 🔗 Listen and subscribe: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Fran Balamuth of @upenn.edu and Scott Weiss of @jeffersonuniv.bsky.social will present “A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis.” Join us! 🔗 duke.is/pctnews20260...

The NIH Office of Disease Prevention will offer a webinar on treatment effect estimation in cluster randomized trials on July 29 as part of its Methods: Mind the Gap webinar series, featuring Bingkai Wang of the University of Michigan School of Public Health. duke.is/pctnews20260...

July 6, 2026: NIH Offers Methods Webinar on Treatment Effect Estimation in Cluster Randomized Trials - Rethinking Clinical Trials

The NIH Office of Disease Prevention will continue its Methods: Mind the Gap webinar series on July 29 with “From Working Models to Reliable Evidence: Robust and Efficient Analysis of […]

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In the OPTIMUM trial, mindfulness-based group telehealth visits led to significant improvements in pain for patients with chronic low back pain. Learn more about the results of this innovative pragmatic clinical trial conducted in real-world primary care settings. duke.is/pctnews20260...

Congratulations to Fan Li, a longtime member of our Biostatistics and Study Design Core Working Group. Dr. Li received well-earned recognitions from ASPPH and COPSS for his foundational work in pragmatic trials research methods and his contributions to public health science. duke.is/pctnews20260...

June 29, 2026: NIH Collaboratory Biostatistics Expert Fan Li Receives ASPPH and COPSS Awards - Rethinking Clinical Trials

Congratulations to Fan Li, associate professor of biostatistics at the Yale School of Public Health, for receiving the Early Career Research Excellence Award from the Association of Schools and Progra...

duke.is

🎙️ In a new episode of the NIH Collaboratory Podcast, Brad Hammill and Keith Marsolo of @dukemedschool.bsky.social discuss the challenges and methods associated with the use of death as an endpoint in pragmatic clinical trials. 🔗 Listen and subscribe: duke.is/pctpod

📣 In this week's PCT Grand Rounds, Phillip D. Levy of Wayne State University will present “Precision Engagement to Improve Population Health.” Join us! 🔗 duke.is/ptcnews20260...