If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications: doi.org/10.1038/s414...

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome - Nature Communications

K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the hum...

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What a day! We published two papers describing the lives of proteins from Alpha shorturl.at/ZeAG7 to Omega shorturl.at/b79Eu Seeing these processes through the lens of structural biology is so satisfying

We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold. academic.oup.com/nar/article/...

Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome

Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...

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Here’s a brief teaser for our latest preprint reporting the first structures of the K11/K48-branched Ub chain bound to the human proteasome: youtu.be/lAZrYsnoLBc?... Check the full text for more details: biorxiv.org/content/10.1... Thx to @asibc512 for making this possible!

Structural basis of a K11/K48-branched ubiquitin chain bound to the 26S human proteasome

YouTube video by Academia Sinica IBC512

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