Targeting glycosylation to sensitize breast cancer cells to immune therapy (make immunologically “cold tumors” into immunologically recognizable “hot tumors”). Thanks to @smereiter.bsky.social, the whole team and the T. Von Zastrow Foundation!

Stefan Mereiter@smereiter.bsky.social · 2mo ago

🚨 Our newest manuscript is out in Nature Communications: Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential. +6 years in the making. Dive into: tinyurl.com/sialic @meduniwien.ac.at

Congratulations! Mariam successfully defended her master thesis „Mapping ACE2 dependency during SARS-CoV-2 infection” 👏🥂

Congratulations to Max Kellner, former PhD student in Josef Penninger’s lab, who was awarded a Vienna BioCenter PhD Award for his thesis, in which he developed bat-derived organoids to investigate why bats can carry highly pathogenic viruses without falling ill. More: https://imba.science/4r5X0TE

🎉 Congratulations to Max Kellner, former PhD student in the Penninger Lab, who was presented with the ÖGBMT Life Sciences PhD Award Austria. The award recognizes Kellner’s PhD research on how dangerous viruses emerge from natural reservoirs like bats. More: https://imba.science/3KiRYSN

Molekulare Diagnostik ist in vielen Ländern nicht gut verfügbar. Forscher:innen des @viennabiocenter.bsky.social & @imbavienna.bsky.social, darunter @mjkellner.bsky.social, mittlerweile Gruppenleiter am HZI, stellen @lsajournal.org einen neuen Test vor. www.life-science-alliance.org/content/8/10...

A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings

A critical bottleneck for equitable access to population-scale molecular diagnostics is the limited availability of rapid, inexpensive point-of-care tests, especially in low- and middle-income countri...

life-science-alliance.org

An organoid platform to study bats' resilience to viral infections - spearheaded by Max and supported by a great team & collaborators: www.nature.com/articles/s41...

Bat organoids reveal antiviral responses at epithelial surfaces - Nature Immunology

Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplif...

nature.com

Max J. Kellner@mjkellner.bsky.social · last yr.

Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology! These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠 www.nature.com/articles/s41...

🎓🧫🔬 Join our lab at Medical University of Vienna as a PhD student investigating glycobiology and cancer research! Details below 👇

Stefan Mereiter@smereiter.bsky.social · last yr.

🚨 PhD position open! 🚨 Join our team at the Medical University of Vienna to study glycan regulation in mammary organoids, milk, and breast cancer. Details in the image – please share! 🧬✨

🦇 Fledertiere können verschiedene hochgefährliche Viren in sich tragen, ohne sichtbar zu erkranken. @mjkellner.bsky.social & @penningerlab.bsky.social haben nun die zellulären antiviralen Abwehrmechanismen in den Schleimhäuten der Tiere untersucht. www.helmholtz-hzi.de/media-center...

Great collaboration on blood vessel organoids to model human vascular development and disease 🧫🔬

@marinanikolova.bsky.social · last yr.

Happy to share our resource for blood vessel organoids! @zhisonghe.bsky.social, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto Barbara Treutlein, @graycamplab.bsky.social, @penningerlab.bsky.social

For research times have become more difficult in many places. We want to spread positivity and show appreciation for our city: We enjoy living and conducting research in Vienna – great science, hospitals, people & art! #IchForscheGernInWien #Wien

Huge congrats to Gustav Jonsson on his successful completion of his PhD studying biomarkers of clear cell renal cell carcinoma! 💛 #proudlab

Proud of Max Kellner, who defended his PhD this week. A successful conclusion of his PhD journey and start of his own group very soon! 🦇🧫🦠

1/ Hi 🦋! Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬 Curious about how they vary? Let’s dive in! #GlycoTime

Perfect for our first post: big collaborate effort spearheaded by Masahiro Onji showing how sex hormones and RANK regulate gut expansion during reproduction 🤰🤱

Masahiro Onji@masaonj.bsky.social · 2y ago

Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators. The paper shows how RANK drives intestinal epithelial expansion during reproduction. #intestine #stemcells #pregnancy www.nature.com/articles/s41...