Perry Group
@perrychem.bsky.social
Synthetic Organic Chemistry Group at the University of Southampton www.perrychem.net
Great visit to Uni of Greenwich's Medway Campus hosted by Xacobe Cambeiro and @klchemistry.bsky.social. A beautiful campus steeped in maritime history ⚓️ (...and a distillery nearby 🍸). Great discussions with fantastic staff and super bright students! Looking forward to #Syntech2026 in July.
Our review on CO2 Transfer and Carbon Isotope Exchange is out in Organic Chemistry Frontiers. @rsc.org Thank you to the editors for the highlight in their Emerging Investigator Series 🙇 pubs.rsc.org/en/content/a... @unisouthampton.bsky.social, @astra-zeneca.bsky.social
Carbon Isotope Exchange and Transfer Reactions involving CO2
Carboxylation reactions are fundamental transformations in organic chemistry, enabling the synthesis of diverse and valuable compounds, including polymers, pharmaceuticals, and agrochemicals. In recen...
pubs.rsc.org
Our latest work on Dual-Function Reagents is out in @chemcomm.rsc.org. Thank you to the editors for the highlight in their Emerging Investigator Collection 🙇 Fantastic work by Katherine Marris 🥼 Great team effort @unisouthampton.bsky.social, @astra-zeneca.bsky.social 🎉 pubs.rsc.org/en/content/a...
Switchable N–H vs C3–H Carboxylation of Indoles using Dual-Function Reagents
The carboxylation of indoles through a CO2 transfer reaction with carboxylate salts is described. By altering the reaction conditions either N–H or C3–H carboxylation can occur. The reaction is also a...
pubs.rsc.org
Our work on Decarboxylative Metal-Halogen Exchange is now out in JACS Au @pubs.acs.org 🙌 Brilliant work by Danny Ryder 🥼 and a great collaboration with Ken Yamazaki 💻 pubs.acs.org/doi/10.1021/...
Aryl Halide Carboxylation via Decarboxylative Metal–Halogen Exchange
A unique mode of metal–halogen exchange is reported for the carboxylation of aromatic halides. The process is mediated by the potassium salt of a commercially available carboxylic acid, which acts as the source of CO2 and metalating agent. The procedure demonstrates that readily available, bench-stable carboxylic acid salts can generate metalating agents in situ for metal–halogen exchange, thus avoiding sensitive and hazardous organometallics. The carboxylation proceeds under mild conditions, shows broad substrate scope and avoids specialized apparatus such as pressurized containers or strictly inert conditions. Application to the carbon isotope labeling of biologically relevant compounds is also reported, including a late-stage carbon isotope exchange. Experimental and computational studies support our proposed mechanism of decarboxylative metal–halogen exchange in which the metalating agent and CO2 are generated in situ from the carboxylate salt.
pubs.acs.org
A Para-Selective Kolbe-Schmitt Reaction out now in @angewandtechemie.bsky.social 🚨 onlinelibrary.wiley.com/doi/10.1002/... No need for high-pressure CO2, excessive temperatures or stringently dry conditions. Our reagent unlocks a simple Kolbe-Schmitt-type reaction with unique para-selectivity.
A Para‐Selective Kolbe–Schmitt Reaction
Discovered over 150 years ago, the Kolbe–Schmitt carboxylation has established itself as one of the most well-known chemical reactions. However, the process often requires extreme pressures and high ...
onlinelibrary.wiley.com
We have a fully-funded PhD position available in our group. For those interested in organic synthesis and developing their lab skills. 🧪 Feel free to get in touch for informal enquiries. www.findaphd.com/phds/project...
New reagents and reactions for isotope labelling at University of Southampton on FindAPhD.com
PhD Project - New reagents and reactions for isotope labelling at University of Southampton, listed on FindAPhD.com
findaphd.com
Brilliant teamwork! Great watching this project grow by connecting chemists and engineers based in the UK and Japan. Congrats all! 🤝 pubs.rsc.org/en/content/a... @chemicalscience.rsc.org @amnightingale.bsky.social, @hideki-kuchem.bsky.social @unisouthampton.bsky.social
Photoredox catalysed reductive cleavage of dibenzothiophene dioxides enabled by a temperature-controlled photoreactor
The cleavage of C–S bonds in dibenzothiophene dioxides under reductive photoredox catalysed conditions is reported. The reactions afford sulfinates, which can be used in a variety of subsequent transf...
pubs.rsc.org
Great to have Giannis, Alex, Grace and Emma join us as PDRAs and 4th Year MChem students 🤝 Also welcome back Siyuan Wang - he did an MRes project with us and enjoyed it so much he has stayed for a PhD. Exciting to see the group grow!
@rsc.org Election results are in! Congratulations to our successful members. Thank you to all candidates for wanting to contribute to our future success www.linkedin.com/posts/roysoc...
Congratulations to all the winners of the Royal Society of Chemistry 2025… | Royal Society of Chemistry | 11 comments
Congratulations to all the winners of the Royal Society of Chemistry 2025 elections! We're proud to announce our newly elected representatives who will help shape the future of chemistry. * Electe...
linkedin.com
Great to have Joshua Barham (University of Strathclyde) visit us this week. Great to have him back in the UK. An impressive body of work and a fantastic addition to the UK chemistry community 🌟 Thanks for visiting us Josh!
Last few days to apply! Deadline: Thursday 29th May.
Perry Group@perrychem.bsky.social · last yr.📢 Come join us in sunny Southampton ☀️ The opening for our Postdoctoral Research Associate in Organic Synthesis is now live! jobs.soton.ac.uk/Vacancy.aspx?ref=3086025EB Deadline: Thurs 29th May 2025 Start date: Flexible – anytime from now to early 2026 @unisouthampton.bsky.social
Another beautiful day ☀️ Another great lecture Thank you to Rachel Grainger from Astex Pharmaceuticals for visiting us yesterday. A captivating talk on automation and HTE in medicinal chemistry. Small organic molecules are still big business! @unisouthampton.bsky.social
📢 Come join us in sunny Southampton ☀️ The opening for our Postdoctoral Research Associate in Organic Synthesis is now live! jobs.soton.ac.uk/Vacancy.aspx?ref=3086025EB Deadline: Thurs 29th May 2025 Start date: Flexible – anytime from now to early 2026 @unisouthampton.bsky.social
Great to have Liam Ball visit us today in Southampton for his @rsc.org Hickinbottom Prize lecture. A beautiful sunny day for it too ☀️ Thank you for coming to visit us Liam and show the superb work you and your team have achieved! @unisouthampton.bsky.social
We will soon advertise a PDRA position in our group. Link to the official advert to follow. Start date is October 2025, but earlier/later is possible. Get in touch with Greg now to discuss further. More details/contact info available on our website: perrychem.net/join-us ☀️
Great to see the group enjoying the Bristol Synthesis Meeting. A true highlight of the year for synthetic/organic chemistry in the UK. Love hearing everyone coming back inspired and motivated. Varinder Aggarwal and the organisers always make this a fantastic event.
Very impressed with the CSJ Annual Meeting. Remarkable organisation. ~4,000 presentations and 6,000 attendees. Every session running to time and well attended. All chemistry disciplines represented and events/childcare for families too. 1/4
I've met many people for the first time during CSJ nenkai. Often this has felt quite formal - exchanging business cards, 🙇. So meeting Fujihara-sensei (Kyoto) and Takeda-sensei @takephos.bsky.social after they led a science event for families will live long in the memory. Great stuff!
Rush hour in Osaka 🚗🚆🛵 Looking forward to the next few days of science at the Chemical Society of Japan Annual Meeting.
Group road trip! 🚗 Last week we visited Cambridge to visit the new AstraZeneca DISC facility, explore the corridors of Girton College and attend the International Isotope Society UK Annual Symposium. Looking forward to returning next year!
