"profiled fitness responses to over 600 bioactive and natural compounds, revealing broader and more polarized bioactivity than the standard #yeast gene-deletion collection" #Saccharomyces

Joseph Schacherer@schacherer.bsky.social · 2w ago

Excited to share our latest #haploteam paper! We developed a barcoded collection of 520 natural yeast isolates to screen 600+ compounds at population scale, uncovering how natural genetic variation shapes chemical responses. Congrats to Abhishek and Marion, who led this work! doi.org/10.1038/s414...

"fungi are reliable biomarkers for gut maturation, with the notable emergence of #Saccharomyces and Malassezia as some of the strongest indicators. Fungal composition was strongly associated with infant age and with the later development of both atopic dermatitis and food allergy" #mycobiome

Nature Portfolio@natureportfolio.nature.com · last mo.

The results of a study in Nature Communications highlight the early life mycobiome as a potential therapeutic target to mitigate allergic disease development. go.nature.com/4xO6pST #microbiome #medsky 🧪

It is always a challenge but also fun to go back to partially completed projects: this manuscript supplementary file happens to be last modified in Nov 2020... Time to wrap things up! #Saccharomyces #lablife

1/2 Happy to share this #Saccharomyces epidemiological study led by @renatokovacs1.bsky.social: retrospective analysis of all patients with S. cerevisiae isolated from sterile body sites between January 2019 and December 2025 in Debrecen. Rare sterile-site infections associated with high mortality!

Renátó Kovács@renatokovacs1.bsky.social · 2mo ago

rdcu.be/fk5fx Not all probiotics are harmless: our new study shows that Saccharomyces cerevisiae can cause rare but severe sterile-site infections in critically ill patients — especially in ICU settings, after GI surgery, or with central venous catheters. 🍄💊 with @pflieglerlab.bsky.social

www.sciencedirect.com/science/arti... Decoding alcoholic beverage and brewing practices of the Qin state during the Warring States period (475-221 BC) based on archaeological evidence. "Qin people mastered brewing and qu production during the Warring States period." #yeast

Decoding alcoholic beverage and brewing practices of the Qin state during the Warring States period (475-221 BC) based on archaeological evidence

China is one of the earliest regions to consume alcoholic beverages in the world. More and more ancient alcoholic beverage residues have been found in…

sciencedirect.com

Prof. Csaba Szabó from University of Fribourg giving an invited talk at our University of Debrecen on the reproducibility crisis in #science!

Most of my at-home fermentation experiments are successful, this one is not :) It took me a looooot of time to get my hands on viable and pure Monascus from red yeast rice products. After inoculating to steamed rice, the Rhizopus-like and Aspergillus-like molds took over the slow-growing Monascus:

Low-level contamination confounds population genomic analysis and also phylogenomics in this example of #yeast #Saccharomyces. Very important: "Contamination rates differed however among sequencing centers: was high for 2 #Saccharomyces studies (2% or 15% of genomes)."

Genetics Society of America@genetics-gsa.bsky.social · 3mo ago

It is no surprise that contamination leads to incorrect conclusions in population genetics studies. @audreykward.bsky.social, @mcmomany.bsky.social, @dbensasson.bsky.social caution that even low-level contamination has a greater impact on analyses than expected. More in #G3journal: buff.ly/kYFXQfM

This week we conclude our General and Applied Microbiology Lab class with 1st year BSc students at UDebrecen. We spent the semester with studying sourdough yeasts and bacteria, with spp identification, genetic fingerprinting, and classic microbiological experiments. We also made new sourdoughs...

Exactly 10 yrs ago I had the incredible opportunity to observe horseshoe crabs in their natural habitat, a majestic species I first have seen in David Attenborough's Trials of Life series, back in the 90s, on VHS:) Happy 100th Birthday, Sir! naturephoto-walter.blogspot.com/2016/05/atla...

Atlantic Ocean at Cape Cod, USA (Atlantischer Ozean bei Cape Cod, USA) (Atlanti-óceán Cape Cod-nál, USA) 05.2016.

We visited the Cape Cod National Seashore in Massachusetts in May to photograph the annual spawning of the horseshoe crabs, ancient-...

naturephoto-walter.blogspot.com

Real #cask ale or real ale from the UK is a wonderful beverage often described as a "live product", with live yeasts responsible from secondary fermentation and carbonation. I found only one scientific paper on cask ale pubmed.ncbi.nlm.nih.gov/36073539/ so I had to try isolating from it in London:)

Insights from sourdough redefine the domestication landscape of baker's #yeast. #yeastevolution Can't wait to read this @caitismuheil.bsky.social !

Caiti Smukowski Heil@caitismuheil.bsky.social · 3mo ago

Super excited to share our lab's work led by PhD student Margot Ruffieux on domestication of Saccharomyces cerevisiae, with a focus on sourdough and baking associated yeast! 🍞

We are on a short trip in London, tasting some real #cask ale at The Lucas Arms :)

#Mycosphere This groundbreaking study reveals incredible hidden microbial diversity in tropical ecosystems and expands our understanding of fungal ecology. 🔬 Details: https://www.maxapress.com/article/doi/10.48130/mycosphere-0026-0002 #fungalecology #species #flowerstyle #ecosystems

In #yeast probiotic news: www.fzata.com/post/fzata-i... Fzata's new drug candidate, in fact a probiotic #Saccharomyces, FZ002, is designed to neutralize both of the main C. diff toxins (toxin A and toxin B). Clinical trials, sponsored by NIH, are planned to begin in summer of 2026 upon FDA clearance

Fzata's Innovative C. diff Infectious Disease Therapy: A New Hope in Biotech

April 9, 2026C. diff (short for Clostridioides difficile) is a serious infection that affects the gut. It can cause intense diarrhea, painful cramping, and extreme fatigue—sometimes lasting for weeks....

fzata.com

Farmhouse #yeast show sexual competence, influencing their evolution trajectory #Farmhouse yeasts show phenotypic diversity but also common domestication traits #yeastevolution www.cell.com/current-biol...

Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity

Bircham et al. show that traditional European farmhouse brewing preserves genetically diverse, sexually competent Saccharomyces cerevisiae populations that are genetically and phenotypically distinct ...

cell.com

Lars Marius Garshol@larsga.bsky.social · 4mo ago

Finally, after 8.5 years, this massive new farmhouse yeast paper is out! We've analyzed no less than 1760 yeast samples, and discovered that there is more farmhouse yeast than all known modern beer yeast put together. New results about contamination, too. www.garshol.priv.no/blog/440.html

Randy W. Scheckman presenting a special lecture at our University of Debrecen - he won the 2013 Nobel Prize in Physiology or Medicine for using baker’s #yeast to uncover the genetic machinery regulating vesicle transport!

Today we made great progress with a new multi-locus sequence typing approach under development for #Saccharomyces with two BSc students - this is all their work! Looking forward to analyze the sequences :)

Candida Genome Database’s new website is live! #yeast

Gavin Sherlock@gsherloc.bsky.social · 4mo ago

The Candida Genome Database’s new website is now live! Everything has been entirely rewritten from scratch! A quarter of a century old Perl code (some of which I wrote!) producing HTML 2.0 (😬) is all gone, with modern python in its place, producing modern webpages with JavaScript and CSS to make

With my recent trip to Rio de Janeiro, I managed to visit 26 Terrestiral Ecoregions of the 846 existing ones to do at least some nature photography and exploration. Still a lot to go! I also visited 9 Marine Ecoriegions (of 232) and 13 Freshwater Ecoregions (of 426).

www.nature.com/articles/s42... It is so great to see this paper finally out! w/ @alexandraimre.bsky.social we started this project years ago. We checked what phenotypes of the probiotic #yeast are selected for in an experimental 🐭 bloodstream infection in 6 different S. 'boulardii' backgrounds /1

Alexandra Imre@alexandraimre.bsky.social · 5mo ago

After many years of work, our study with @pflieglerlab.bsky.social on a Saccharomyces boulardii probiotic with diminished virulence is now published!! I want to express my sincere gratitude to all the authors for their contributions and support! www.nature.com/articles/s42...

We opened a Brazilian wild #yeast fermented red wine I brought back from Rio. Very nice, strong notes of chocolate and red fruit!

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

www.biorxiv.org/content/10.6... comparison of commercially available #Saccharomyces #mead yeasts. Our new preprint w/ @balintnemeth.bsky.social and colleagues compares 13 mead #yeast strains for their phenotype, genome, and presents data on metabolites in experimental mead fermentations.

Yesterday at Rio Botanic Garden :)

I arrived to the Federal University of Rio de Janeiro to André dos Santos' lab, meeting with students incl. @raquelvicente.bsky.social who visited us in Debrecen a year ago! Excited to give a course on #yeast genomics :) and present on our results in this enchanting city!

📢 In our new study, we identify the predominant natural route to polyploidy in S. cerevisiae. Stepwise polyploidization operates through iterative cycles of events termed "Sporulate–Endoreplicate–Mate" (SEM). Really excellent work led by @cintiagomez.bsky.social 👏 www.biorxiv.org/content/10.6...

With a 2019 Fuller's vintage ale, celebrating the acceptance of a paper w/ @alexandraimre.bsky.social that we started working on in 2019. So happy to have saved this for all these years! What a long journey! The topic is #yeast probiotics, will be online very soon!

"Ancient co-option of LTR retrotransposons as yeast centromeres" #yeastevolution

Max Haase@maxhaase.bsky.social · 6mo ago

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

With @litinice.bsky.social, we built a haploid resource from 33 wild Taiwanese Saccharomyces cerevisiae strains — including some of the most genetically divergent Asian lineages — to bring natural yeast diversity into a genetically tractable framework. www.biorxiv.org/content/10.6...