[Research progress and future prospects of phage application in the treatment of mastitis in dairy cows].

pubmed.ncbi.nlm.nih.gov

[Research progress and future prospects of phage application in the treatment of mastitis in dairy cows].

pubmed.ncbi.nlm.nih.gov

[Research progress and future prospects of phage application in the treatment of mastitis in dairy cows].

pubmed.ncbi.nlm.nih.gov

Quantum Dot-Phage Nanoarchitectonics for Targeted Synergistic Therapy of Methicillin-Resistant Staphylococcus aureus Wound Infections - PubMed

Chronic wound infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) often refractory to conventional therapies due to bacterial drug resistance and biofilm formation. To address this challenge, we developed a synergistic antibacterial nanoarchitectonics integrating bacteriop …

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Mechanistic insights into phthalylsulfacetamide-induced restoration of meropenem bactericidal activity in NDM-1-positive Escherichia coli - PubMed

The emergence and global spread of New Delhi metallo-β-lactamase-1 (NDM-1) pose a severe threat to the efficacy of carbapenems, which are considered the last line of defense against infections caused by multidrug-resistant gram-negative bacteria. In this study, through virtual screening and enzyme a …

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A Chirality-Converted Bacteriolytic Dodecapeptide Regulates Vibrio-Induced Polymicrobial Infection and Ameliorates Invasion-Associated Gut Microbiota Disequilibrium - PubMed

The polymicrobial infections caused by Vibrio species, especially multidrug-resistant isolates, are posing increasing threats to the health of coastal residents. Herein, a novel dodecapeptide, denoted as D-zp37, was designed and synthesized, aiming to combat these notorious pathogens. Experimental r …

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Complete genome sequence of MP2445, a mycobacteriophage that can infect Mycobacterium bovis BCG and Mycobacterium fortuitum - PubMed

Mycobacteriophage MP2445 exhibits siphovirus morphology and infects <i>Mycobacterium smegmatis</i>, <i>Mycobacterium bovis</i> BCG, and <i>Mycobacterium fortuitum</i>. Its genome is 50,711 bp in length, has a GC content of 63.34%, and contains 78 protein-coding sequences and one tRNA. MP2445 shares …

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Assessing non-porous antimicrobial surfaces against bacteria, phages and fungi: a comparative study under varied normative conditions using glass as a benchmark for microbial persistence - PubMed

The survival of pathogenic microorganisms on surfaces is contingent on environmental factors, including humidity and temperature. In order to analyze the survival and persistence in vitro, different protocols have already been implemented. This has resulted in a wide range of survival rates of all k …

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A Triple-Modality Peptide-Antibiotic-Phage Therapy Eradicates Multidrug-Resistant Serratia marcescens Biofilms - PubMed

A triple-combo of peptides, antibiotics, and phages completely wiped out MDR Serratia marcescens biofilms.

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A Triple-Modality Peptide-Antibiotic-Phage Therapy Eradicates Multidrug-Resistant Serratia marcescens Biofilms - PubMed

A triple combo of peptides, antibiotics, and phages completely wipes out MDR Serratia marcescens biofilms.

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Comparison of gut viromes across captive mammals reveals extensive genetic diversity in bacteriophage dark matter and mammalian viruses - PubMed

Comprehensive characterization of mammalian gut viromes is essential for early detection of commensal and potentially zoonotic viruses and for reducing the risk of cross-species transmission. Viral metagenomics was applied to profile gut viral communities from zoo mammals maintained across multiple …

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Quantum Dot-Phage Nanoarchitectonics for Targeted Synergistic Therapy of Methicillin-Resistant Staphylococcus aureus Wound Infections - PubMed

Chronic wound infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) often refractory to conventional therapies due to bacterial drug resistance and biofilm formation. To address this challenge, we developed a synergistic antibacterial nanoarchitectonics integrating bacteriop …

pubmed.ncbi.nlm.nih.gov

Engineering a Self-Lysing Attenuated Salmonella Typhimurium with Flagellar Display of RGD4C for Targeted Tumor Therapy via l-ASNase Delivery - PubMed

Conventional cancer therapies, such as radiotherapy, chemotherapy, and surgery, exhibit notable limitations in the treatment of solid tumors. Bacteria-mediated tumor therapy has been proven to be effective in clinical studies and is regarded as a promising strategy for tumor treatment. <i>Salmonella</i> …

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Bacteriophage titering by optical density means: KOTE assays - PubMed

Bacteriophages, or phages, are the viruses of bacteria. Since at least the later 1940s, researchers have studied phages using spectrophotometrically determined measures of bacterial-culture turbidity (optical density). Recently, two groups have proposed the use of kinetic visualizations of phage-ind …

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Highly Efficient Virus Rejection with Self-Organized Membranes Based on a Crosslinked Bicontinuous Cubic Liquid Crystal - PubMed

To remove viruses from water, the use of self-assembling liquid crystals is presented as a novel method for the synthesis of membranes with a regular pore size (below 1 nm) and controlled pore structures. Nanostructured bicontinuous cubic liquid-crystalline (LC) thin films are photopolymerized onto …

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Enhanced multi-omic viral profiling from microbial community sequencing with BAQLaVa - PubMed

Viruses are crucial components of microbial communities, both phage that infect bacterial community members as well as pathogenic and other eukaryotic viruses. However, they remain unobserved by most current technologies, due to combinations of experimental and analytical factors. To address the lat …

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StackPVP: a stacked ensemble classification framework for predicting phage virion proteins using integrated evolutionary features - PubMed

Phage therapy has attracted increasing attention as a potential antibacterial strategy. Phage virion proteins (PVPs) are vital for recognizing host cells and binding to their surface receptors. Thus, accurate PVP identification is essential for developing antibacterial agents. In this study, we intr …

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Characterization of DNA Viruses in Hindgut Contents of Protaetia brevitarsis Larvae - PubMed

The scarab species <i>Protaetia brevitarsis</i>, an edible insect, has been used in traditional medicine, as animal feed, and for converting agricultural organic wastes into biofertilizer. The intestinal tract, which contains a diverse array of microbiota, including viruses, plays a critical role in …

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Recurrent phage treatment of Salmonella-infected chickens transiently reshapes gut microbiota composition and function - PubMed

Bacteriophages (phages) are viruses that target bacteria and hold great promise as therapeutics against multidrug-resistant bacteria, pathogen infections, and for microbiota engineering. Despite their potential, the effect of phage therapy on gut microbiota remains insufficiently explored. This stud …

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New horizons of nanotechnology-enabled phage therapies for effective management of bacterial infections - PubMed

Bacterial infections continue to persist as a major global healthcare challenge, exacerbated by the alarming rise of antimicrobial resistance (AMR) that renders conventional antibiotics increasingly ineffective. In response, bacteriophage therapy has re-emerged as a viable alternative to antibiotics …

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Identification of chalcopyrite-binding peptides for flotation applications using phage display and deep sequencing - PubMed

Phage display is a powerful technology for identifying new ligands, including mineral-selective peptides. However, it is prone to several biases that may lead to false positives or false negatives, particularly due to non-specific binding, amplification bias, and the limited number of clones typical …

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Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses - PubMed

Cryo-electron microscopy (cryo-EM) has revolutionized structural virology, enabling routine structure determination at 2-4 Å resolution, with exceptional cases reaching 1.56 Å. The structural diversity of viruses across vertebrate, plant, and insect hosts provides fundamental insights into infection …

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Alternating High-Fat and Polysaccharide Diets Modulates Gut Phage-Bacterial Interplay - PubMed

Phages dominate the human gut virome and are known for their ability to prey on bacteria and shape microbiota. However, their response to diet has only been elucidated using small-scale studies. By integrating a massive meta-analysis of 6932 diet-associated metagenomes with a time-resolved mouse mod …

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Bacteria and phage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks - PubMed

Collectively, these findings provide novel insights into the gut microbial factors regulating FE in ducks, offering potential strategies to optimize poultry nutrition and productivity. Video Abstract.

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Phages as antimicrobials against multi-drug resistant bacteria - PubMed

Multi-drug resistant bacteria (MDR) pose a major public health challenge. Their ability to exchange resistance genes through Horizontal Gene Transfer (HGT) promotes the appearance of resistant strains, limiting antibiotic treatments for infections caused by these MDR bacteria. Among alternative appr …

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Identification of non-toxic AAV capsid variants with enhanced deep retinal transduction and extended distribution following subretinal delivery - PubMed

Subretinal injection remains the standard method for delivering genes to the retina. However, diffusion into deeper retinal layers is often limited by sequestration of wild-type AAV2 vectors at the retinal pigment epithelium (RPE). In this study, we used in vitro phage display strategy to identify n …

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Colibactin produced by a honeybee symbiont defends against pathogens and shapes the gut community - PubMed

Colibactin is a bacterial genotoxin that is linked to colorectal cancer and implicated in interbacterial competition; however, its role in natural communities remains unknown. <i>Frischella perrara</i>, a symbiont living only in honeybee guts, produces colibactin and causes DNA damage. Here, we foun …

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Longitudinal multi-omics reveal phase-dependent viral adaptive strategies and functional potential during formation of algal-bacterial granular sludge - PubMed

Virus-prokaryote interactions within microbial aggregates critically influence microbiome function and stability, yet the interactive dynamics during microbial aggregation remain largely unexplored. Here, longitudinal multi-omics revealed that prokaryotic host community diversity underwent decline a …

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Therapeutic potential of three virulent bacteriophages targeting clinical Enterobacter hormaechei strains: comprehensive biological properties and genomic functional analysis - PubMed

The emergence of multidrug-resistant Enterobacter cloacae complex (ECC) strains, particularly Enterobacter hormaechei, underscores the urgent need for alternative antimicrobial strategies. This study reports the isolation and comprehensive characterization of three virulent bacteriophages - Enteroba …

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