Tune in for a great MIA talk on ML for regulatory genomics by @jmschreiber91.bsky.social and Gregory Andrews now! 🧪 broad.io/mia (Will also be available online on our YouTube playlist later: www.youtube.com/watch?v=sMTO...)

🧪 Super excited to host Gokcen Eraslan and Surag Nair from Genentech at MIA this Wednesday! They will describe a new multimodal masked modeling framework for functional genomics, which unifies sequence-to-function models, language models and synthetic sequence design. x.com/MIA_at_Broad...

Tomorrow, I am super excited to be hosting Ellen Zhong & Rishwanth Raghu from Princeton at the MIA seminar, who will discuss deep learning models to reconstruct 3D protein complexes and study biomolecular dynamics from 2D cryoEM/cryoET images 🧪https://x.com/MIA_at_Broad/status/1899195133201170569

Our ChromBPNet preprint out! www.biorxiv.org/content/10.1... Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants

Despite extensive mapping of cis-regulatory elements (cREs) across cellular contexts with chromatin accessibility assays, the sequence syntax and genetic variants that regulate transcription factor (T...

biorxiv.org

Anshul Kundaje@anshulkundaje.bsky.social · 2y ago

Aiming to release our long awaited ChromBPNet preprint by early next week as well. I'm recovering from back to back infections for the past 6 weeks. But we're almost there. We have some solid variant prediction benchmarks in there against large supervised models and lots more. Stay tuned.

hi everyone!! let's try this optimal transport again 🙃

I would put this even more strongly: open source AI is probably our only realistic chance to avoid a terrifying increase in concentration of power. I do not want to live in a world where the people with all the money also have all the intellectual power.

Nathan Lambert@natolambert.bsky.social · 2y ago

The most realistic reason to be pro open source AI is to reduce concentration of power.