📣 Our lab is recruiting postdocs to lead new fully funded projects on mechanisms of microbiome–gut–brain signaling & microbial regulation of brain–body interactions in disease, w supportive clinical collaborators. Expertise in gut–brain, systems neuro, or neuroimmunology preferred. Please email 📧

Microbe-mediated stress? Microbial metabolite Imidazole propionate reaches brain, dampens hypothalamic activity & promotes stress-related behaviors. In humans, higher ImP is associated w/reduced hypothalamic responses & emotional eating @pipethero.bsky.social www.cell.com/cell-host-mi...

The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors

Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...

cell.com

Excited to share new work by Guli Agirman + co that identifies a direct mechanism linking gut microbial imidazole propionate to stress! 🧠🦠 Btw this image was made by Nano Banana Pro 🍌. First time I've gotten a model to accurately generate a science graphic 🤯 authors.elsevier.com/a/1mA5M6t8JE...

Happy to share this paper in final form rdcu.be/eH8tj, with more info on neuronal responses and potential mechanism of actions! The results suggest that there is neural interoception of microbial metabolic state 🧠🦠 We hope they can inspire more work in this area!

Complex carbohydrate utilization by gut bacteria modulates host food consumption

Nature Communications - Gut bacteria digest dietary fiber and release molecules as energy for the host. Here, Yu et al. find that the ability of certain gut bacteria to digest different fibers...

rdcu.be

Elaine Hsiao@pipethero.bsky.social · 2y ago

Delighted to share work by Kristie Yu, Celine Son, & co showing that selective fructan metabolism by the gut microbiome can contribute to host associative learning of dietary preference, even when it comes to choosing between diets with the same perceptual salience (and macronutrient composition!)

Delighted to share this perspective piece by Lewis Yu on microbial regulation of serotonin and neuroimmune interactions. Looking forward to sharing more on this topic soon 🤞 www.sciencedirect.com/science/arti...

Microbial regulation of serotonin and neuroimmune interactions

Bidirectional communication between the gut microbiota and neuroimmune system is essential during host–microbiome interactions. Recent research has be…

sciencedirect.com

5/5 Awardee @chuchuzhang.bsky.social explores how different body states (eg, pregnancy) may change what neurons sense & how they respond. Her work may lead to new ways to address nausea associated w/ pregnancy🤰 & chemo. 🍾Congrats Dr. Zhang! @dgsomucla.bsky.social 🙏 #HFScout @pipethero.bsky.social

🧪our paper in @cp-cellhostmicrobe.bsky.social selected as NIEHS papers of the month! 🔥🔥 pubmed.ncbi.nlm.nih.gov/40315838/ @pipethero.bsky.social @scrippsocean.bsky.social

Extramural papers of the month

urldefense.com

Thrilled to share this collaborative work by Kristie Yu, Francis Chandra, Amina Schartup and teams @Scripps_Ocean and @UCLA showing that an engineered gut bacterium can be used to reduce the neurotoxic effects of dietary methylmercury www.cell.com/cell-host-mi...

An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice

Yu and Chandra et al. engineered a commensal gut microbe, Bacteroides thetaiotaomicron, to detoxify methylmercury (MeHg). The engineered bacterium reduces MeHg in the intestinal lumen, limits its accu...

cell.com

Curious about how the gut microbiome modulates the neurological health of pregnant women and their offspring? Check out my recent review with @pipethero.bsky.social out now @jclinical-invest.bsky.social! 🦠🤰👶🧠 www.jci.org/articles/vie...

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity www.cell.com/iscience/ful...

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling

Neuroscience; Microbiome

cell.com

Very happy to share new findings by Ezgi Özcan and colleagues showing that differences in fiber content in medical ketogenic diets can influence their anti-seizure effects! www.nature.com/articles/s41...

Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice - Nature Communications

Here, the authors show that different formulations of medical ketogenic diets, and dietary fiber content in particular, differentially impact seizure outcome in mice, via modifying the gut microbiome ...

nature.com

Now let me welcome @gdonaldson.bsky.social back to the wild wild West... We are excited to have you join our science family at UCLA #GoodmanLuskinMicrobiomeCenter. Lots more microbiome magic will be on the way! ✨

Gregory P Donaldson@gdonaldson.bsky.social · 2y ago

Goin back to Cali. Find me at UCLA. I’m recruiting at all levels. You can learn more at our lab website: www.donaldsonlab.com We have an advertisement up for a technician (SRA) position: jobs.ucla.edu/jobs/5998

Happy to kick off 2025 with this new review on gut microbiota-neuroepithelial signaling by the very talented Taka Ohara!

Nature Reviews Microbiology@natrevmicro.nature.com · 2y ago

It was an honor to highlight this fantastic work by Cheng and Venkatesh et al of the Gordon lab. Many thanks to them, and to Francis Chandra for doing all the heavy lifting on this Spotlight! @cp-cellchembiol.bsky.social

Sean Gibbons 🦠💩@gibbological.bsky.social · 2y ago

Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org doi.org/10.1016/j.ch...

Delighted to share work by Kristie Yu, Celine Son, & co showing that selective fructan metabolism by the gut microbiome can contribute to host associative learning of dietary preference, even when it comes to choosing between diets with the same perceptual salience (and macronutrient composition!)

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y ago

Complex carbohydrate utilization by gut bacteria modulates host food preference https://www.biorxiv.org/content/10.1101/2024.02.13.580152v1