Pawel Lorkiewicz
@pklork01.bsky.social
Mass Spec nerd and Associate Professor at University of Louisville I create extensive exposomics and stable isotope resolved metabolomics workflows to link environmental exposures with health outcomes. Current focus: Phase II metabolomics
HAPPY PRIDE 🏳️🌈 Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them. Stand with us to protect LGBTQ+ science from political erasure. grant-watch.us/nih-data.html @rcmedphys.bsky.social
Starting my #ASMS2025 adventure with Waters users meeting. The TQ Absolute XR is definitely a highlight (we have the Absolute and we like it a lot; an increase in robustness is definitely a welcome feature). Decent talks. Getting almost too technical at times but I've learned a lot. #TeamMassSpec
#ASMS2025 is just around the corner. This year we will have two presentations (poster and oral) discussing our approach to #LC-MS profiling and analysis of Phase II metabolites in the urine. #teammassspec
We stand with you in this time of loss and recovery. Please consider donating to the Team Kentucky Storm Relief Fund to support those affected: secure.kentucky.gov/formservices... #TeamKentucky #KentuckyStrong
Our latest manuscript describes an #LCMS platform profiling Phase II metabolites. We annotated 424 mercapturates, glucuronides, sulfates linked to over 200 environmental chemicals. This demonstrates ILGA's value for advancing #Exposomics Link doi.org/10.1016/j.en... #MassSpectrometry #Metabolomics
For my latest, I wrote about my HHS RIF tracking doc and why it felt important to cut through the fog of terror to capture the data:
Tracking the HHS April Fools’ Massacre
The Handbasket has created a document to capture the destruction.
thehandbasket.co
I created a Metabolomics starter pack. A list of researchers from the wonderful world of #metabolomics. If you would like to be added (or removed) just let me know. go.bsky.app/J3VPYKm
When I began in analytical chemistry, I explored organic and inorganic compounds as matrices for MALDI imaging of lipids in the negative ion mode. MALDI-MS and MS-based lipidomics were so new that my early presentations fell under OTHER → other. Things have changed a lot since then.
NEW: NSF confirmed that they fired 168 employees today, out of their staff of ~1,500 feds. This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.
Taking Omega3s and VitD over three years slowed biological aging by 3-4 months when combined with exercise. @ciehs.bsky.social @uoflenvirome.bsky.social
Nature@nature.com · 2y agoTaking omega-3 and vitamin D supplements over a three-year period slowed biological ageing by three to four months, particularly when combined with exercise. https://go.nature.com/4hjjGdO
“Because they wouldn’t let me give it away” my answer when people ask why did I not publish AMMS with a publishing house. Free PDF at Scripps Research: masspec.scripps.edu/about/mass-s... Royalty-free print version at Amazon ($15.08): a.co/d/8dEWO8a
So, *very* unconfirmed, but I've heard from inside a fed agency that there is a chance a significant chunk of gov websites, in particular healthcare and energy-related ones, might just go dark today at 5 pm because it's impossible to scrub the DEI stuff by then.
OK @uoflenvirome.bsky.social 🤩 Thanks for sharing my posts!!! I want to see Bluesky becoming a livelier platform.
I’ve heard from people inside NIH, EPA, the National Cancer Institute, the National Parks Service, and more. Signal info is in bio if you are at any federal agency and want to chat.
'Insulted and Confused': Inside Agencies, Federal Employees React to Mass Resignation Offer
Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.
splinter.com
OK, we've seen it before—use glucuronidase & sulfatase, hydrolyze conjugates, release parent chemical (or phase I met) & measure that. Call us crazy, but we thought "What if we just identify and measure all the conjugates instead?".. So we did. papers.ssrn.com/sol3/papers.... #Massspec #metabolomics
Mapping of Phase Ii Human Urinary Metabolome
Humans are constantly exposed to both natural-occurring and anthropogenic chemicals. Targeted mass spectrometry approaches are frequently used to measure a smal
papers.ssrn.com
New #mzmine release out now! Matching millions of reference spectra against thousands of samples was never faster. Go and test it today. Download: github.com/mzmine/mzmin... youtu.be/AFv55sUn9Lg
New features in mzmine 4.5
YouTube video by mzio GmbH
youtu.be
Thank you for sharing this resource for free @siuzdak.bsky.social
Gary Siuzdak@siuzdak.bsky.social · 2y agoAMMS 2025 book is live, the PDF just became available, and you can freely download the entire book here... masspec.scripps.edu/about/mass-s... Two new chapters, new sections, and refinements throughout. The royalty-free print version of #AMMS 2025 will be available on Amazon next week.
My understanding is that clinical trials should not be interrupted, so hopefully the reports about canceled appointments are done... but it's hard to say. If you are a participant in a clinical trial (or at NIH clinical center) and have seen disruptions, I'd love to hear from you—Signal in bio.
Dave Levitan@davelevitan.bsky.social · 2y agoThe latest on what I've heard from inside NIH and NCI and elsewhere. It's not great!
I have heard some internal confirmation that NIH study sections are being suspended theoretically under the Federal Advisory Committee Act. Which is insane.
Dave Levitan@davelevitan.bsky.social · 2y agoOkay maybe I'm missing it but I don't see much independent confirmation of this, but if it IS happening it is *wild*. It would mean they are literally trying to stop biomedical research from happening.
This looks like a very extensive and useful resource. The authors put a lot of work into this manuscript. Can't wait to read it.
Justin J.J. van der Hooft@jjjvanderhooft.bsky.social · 2y ago🚨 New Publication Alert 🚨 Effective Visualization Strategies in Untargeted Metabolomics - a comprehensive review! This was a real team effort and combined various disciplines! Very #ProudPI in #CompMetabolomics 😊😎 Please find the link and read more about it here: www.linkedin.com/posts/jjjvan...
Our paper describing a dilute-and-shoot targeted LC-MS/MS method for measuring 35 urinary metabolites of #VOCs and #tobacco alkaloids is now published in Journal of Chromatography B. The article is available here: www.sciencedirect.com/science/arti... #MassSpecRSS #teamMassSpec #LC-MS #exposomics
Wildfire smoke is now the top source of harmful PM2.5, microscopic particulate matter that can penetrate into the lungs, in the western U.S.. An environmental toxicologist examines the impact: https://buff.ly/4gPXmbk (Luke Montrose, Colorado State University) 🌎 #climatesky #california #LAfires
LA fires: Long-term exposure to wildfire smoke is poorly understood − and a growing risk
Human bodies aren’t prepared for the toxic chemicals in smoke, and the effects can be harmful in the short term and longterm.
buff.ly
Our paper was accepted for publication in Journal of Chromatography B. Great way to start the week.
The incoming Trump administration plans to target the National Climate Assessment so that it can't be used to defend regulations in court. Russ Vought, Trump's OMB pick, wants to personally approve a team of climate denialists to rewrite it. www.eenews.net/articles/tru...
Trump team takes aim at crown jewel of US climate research
A top aide to the president-elect wants tighter control over the National Climate Assessment.
eenews.net
Here's a preprint of our manuscript papers.ssrn.com/sol3/papers.... a result of ~2 yr of work on #LC-MS ILGA workflow for comprehensive Phase II #metabolomics analysis. We highlight ILGA's use in #exposomics and elucidate impact of #environmental exposures on health. #MassSpecRSS #MassSpectrometry
This manuscript just came out in JBC I'm glad we got to collaborate with Dr Wysoczynski and Tyler Jobe from his lab. Together with De Silva we provided stable isotope resolved #metabolomics data used in the manuscript. Link: www.sciencedirect.com/science/arti... #teammasspec #envirome
Informative and comprehensive review: Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... #exposomics #chemicalexposures #teammasspec #exposurescience
Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome
A large part of the Human chemical exposome is now well characterized, and its health effects has been widely documented, although precise causal links remain difficult to establish. In parallel, gen...
analyticalsciencejournals.onlinelibrary.wiley.com