A friendly reminder that the 9th Austrian Cryo-EM (ACE) Symposium is taking place in Vienna, 24–25 September 2026. We'd love to see you there! Speakers: Chlanda, Costa, Demulder, Hurdiss, Su, Toropova, Weiss and Zhong. Abstract deadline 5 August; talks selected from submissions. shorturl.at/NGRZV

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Automatic screening of cryo-EM grids using EPU is fast and efficient, but reviewing the generated data & picking the best areas for data collection can be slow and cumbersome. We made a little tool that makes this process more streamlined and enjoyable: github.com/mvorlander/E... 1/4

@lorenzoorts.bsky.social previously worked as a postdoctoral fellow at @impvienna.bsky.social in Austria. She will establish a new lab at IMB to investigate how mRNA translation is activated in the early embryo. Welcome to IMB Laura! 💐 Read more here: www.imb.de/about-imb/ne...

Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases. @hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social www.imb.de/about-imb/ne...

mRNA is a key polymer of life. While its sequence is linear, its function requires its 3D organization. Yet what does a mRNA look like in 3D? In collaboration with the fbzt.bsky.social, we developed a method to visualize mRNA in 3D and at the nanoscale inside human cells. tinyurl.com/r858t6ff 1/3

Our leaving gift and starter-pack for @hohmannulrich.bsky.social to open his new lab at @imbmainz.bsky.social! Ulrich has made many exciting contributions to RNA packaging. We will miss him and his dry humor, and can't wait to see what he will discover in his lab!

I’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.

European Research Council (ERC)@erc.europa.eu · 8mo ago

The results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

Congrats to Dr. @julsportell.bsky.social on her PhD! Her journey as a joint student (Brennecke/Our Lab) led to key insights into gene silencing. Paper: www.cell.com/molecular-ce.... Journey: www.viennabiocenter.org/about/news/t.... CP.

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

biorxiv.org