The Platten Lab

@platten-lab.bsky.social

The Platten Lab is interested in novel immunotherapeutic approaches for #glioma and understanding cns autoimmunity.

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma. 🔬 Key findings: ✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient ✅ Kills glioblastoma cells with no off-target effects ✅ Eliminates tumors in murine brain models 🔗 www.nature.com/articles/s41...

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications

Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

nature.com

Today we celebrate the successful PhD defense of Dennis. We congratulate him to his outstanding accomplishments in his work on the irradiated glioma microenvironment and perovascular niches. 🎓

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