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Pliotas Group

@pliotasgroup.bsky.social

Mechanosensitive channels & Membrane Proteins - Structural EPR Spectroscopy at The University of Manchester - DEER/PELDOR/PDS pliotasgroup.org

11 Posts315 Follower240 Folgt
Pliotas Group@pliotasgroup.bsky.social · 3mo ago

In this study published in @natcomms.nature.com we used #PELDOR #DEER #EPR spectroscopy to monitor the entire pH-dependent conformational ensemble of the membrane SbmA peptide transporter www.nature.com/articles/s41...

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters - Nature Communications

SbmA is a proton-driven transporter that imports antimicrobial peptides andstructurally resembles the transmembrane domain of ABC-transporters. Here, authors show through cryo-EM structures, EPR spect...

nature.com

Pliotas Group@pliotasgroup.bsky.social · 5mo ago

In our study in @natcomms.nature.com we used #EPR #DEER #PELDOR spectroscopy with single subunit heterologous spin labelling and monitored the entire cap conformational ensemble of the human mechanosensitive TRAAK channel and showed it adopts two states in membranes. www.nature.com/articles/s41...

Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature - Nature Communications

TRAAK is expressed in the nervous system and helps regulate neuronal excitability. Here, the authors use EPR to quantify the relative populations of TRAAK’s swapped and non-swapped cap states in membr...

nature.com

@stradi-various.bsky.social · 8mo ago

15 PhD positions fully funded! Apply until 6 January 2026 www.findaphd.com/phds/?Keywor... #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #ResearchOpportunities#PhDPositions#MSCA#EU#Antimicrobialresistance#Microbiology#Structuralbiology

stradivarious PhD Projects, Programmes & Scholarships - 26 PhDs Listed

FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in stradivarious. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

findaphd.com

Pliotas Group@pliotasgroup.bsky.social · 9mo ago

We have a new academic post opening for a Lecture/Senior-Lecturer in Structural Biology @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk The University of Manchester is ranked among the top Universities worldwide. QS world rankings: 34th (2025) www.jobs.manchester.ac.uk/Job/JobDetai...

Lecturer / Senior Lecturer in Structural Biology:Oxford Road

The purpose of this post is to undertake high quality research and also excellent teaching. Hence, the ability to enhance teaching activities within our UG/PG programmes will also be expected.

jobs.manchester.ac.uk

International EPR Society@epr-esr.bsky.social · last yr.

2025 IES Medal in Biology/Medicine: awarded to Olav Schiemann for his seminal contributions advancing the field of EPR in Biology via his pioneering efforts to resolve structural aspects of spin labelled nucleic acids and proteins.

Molecular and Cellular Function, University of Manchester@mcf-uom.bsky.social · last yr.

Early-career fellowships at the University of Manchester! To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers: www.bmh.manchester.ac.uk/research/sup...

Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester

Find out about and apply for a Bicentenary Early Career Research Fellowship.

bmh.manchester.ac.uk

Pliotas Group@pliotasgroup.bsky.social · last yr.

In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...

The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore

Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...

cell.com