⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...

Our new review entitled 'Decoding Spliceosome Dynamics through Computation and Experiment' has been published on Chemical Reviews @pubs.acs.org Congrats to @pokorna.bsky.social, Sebastian Fica and Jana Aupic! pubs.acs.org/doi/10.1021/...

Decoding Spliceosome Dynamics through Computation and Experiment

RNA splicing is orchestrated by a complex and exceptionally dynamic RNA–protein machine, called the spliceosome. Stepwise, large-scale structural and compositional remodeling of the spliceosome enable...

pubs.acs.org

Just published: RNA G-quadruplex folding mechanism via all-atom simulations in collaboration with my former PhD lab. Many thanks to Petr, Jiří, Vojtěch, and the reviewers, who encouraged us to pursue folding the full human telomeric G4. academic.oup.com/nar/article-...

RNA G-quadruplexes emerge from a compacted coil-like ensemble via multiple pathways

Abstract. RNA G-quadruplexes (rG4s) are emerging as vital structural elements involved in processes like gene regulation, translation, and genome stability

academic.oup.com