Excited to share our latest review on transcript elongation out now at @natrevmcb.nature.com!! It was an absolute pleasure to work on this review with @isaacfianu.bsky.social and @adelmanlab.bsky.social!

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 4w ago

ICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease

Really nice story from Karen Arndt's lab!

Genes & Development@genesdev.bsky.social · 4mo ago

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination By Sanchirmaa Namjilsuren and Karen Arndt ➡️ https://ow.ly/NO6w50YNzVo #transcription

Happy to share that David and I have a new review out in @annualreviews.bsky.social of Biochemistry! We break down Pol II pausing, its evidence in vitro/in vivo, and its two key fates which are in kinetic competition: pause release vs premature termination. www.annualreviews.org/content/jour...

The Promoter-Proximal Pause: A Decision Point Governing RNA Polymerase II Fate

A signature feature of transcription on most genes in multicellular animals is that RNA polymerase II (RNAPII) piles up approximately 50 bases downstream of the start site at the promoter-proximal pau...

annualreviews.org