Tessera

Excited to be partnering with the Same You Foundation as we start an AMA about brain injury recovery. Follow “SameYouOrg” on instagram to watch!

Incredibly moving and beautiful interview from the one and only Emilia Clarke So wonderful to hear her speaking so openly on so many topics including acquired brain injury, #EDS, joint hypermobility spectrum disorders and #MCAS. 🙏🙏 youtu.be/zSUqrOAMMDU

Emilia Clarke on Imposter Syndrome, Brain Aneurysms, Recovery and the Pressure of Fame

YouTube video by How To Fail with Elizabeth Day

youtu.be

Excited to work with @Invivyd to get this out. One of the most common questions I get from people in the #LongCOVID community are about vaccination alternatives. People still want to protect themselves from SARS-CoV-2 infection but many experience www.medrxiv.org/content/10.6... 1/

Safety first: should the high tolerability of intramuscular anti-spike COVID-19 monoclonal antibody change our expectations of vaccine safety?

Introduction: Public and regulatory scrutiny of immunization safety has intensified in recent years. The COVID-19 pandemic has been instrumental in this. The accelerated timeline of COVID-19 vaccine d...

medrxiv.org

It's a big day at CoRE! The second edition of our Infection-Associated Chronic Conditions and Illnesses Provider Manual is now available at coresinai.org/manual (1/2)

Manual — The Cohen Center for Recovery from Complex Chronic Illness

coresinai.org

We received feedback that folks are not so eager to enter a placebo-controlled trial for fear of being in the placebo arm. So, for our trial looking at low-dose rapamycin for #LongCOVID we now have an open-label extension added to the trial so everyone gets to try it! Reach out!

We just lost an absolute legend in the field of neuro-restoration. V. Reggie Edgerton was a true innovator and fierce driver of change for people with paralysis. I never stopped being in awe of how far he would go to help just one person. Rest easy, Reggie. You did so much 💔

Image of legendary neuroscientist V. Reggie Edgerton standing in his lab with his arms folded

As usual, @julierehmeyer manages to capture things so beautifully here as she reflects on the loss of her dear friend with #MECFS. The feelings and thoughts so perfectly expressed in this piece by Julie are familiar to so many in the community: so many www.nytimes.com/2026/04/03/s... 1/

May I End My Life With You?

nytimes.com

Long Covid Advocacy @longcovidadvoc.com · 4mo ago

Great piece from @thesicktimes about our participation in some #LongCOVID and infection-associated chronic condition and illness education in Santa Barbara. Great coverage of some of the challenges of CME-accredited education as well as the need for thesicktimes.org/2026/03/30/c... 1/

California clinicians gather for Long COVID forum. Recent guides offer direction. - The Sick Times

Clinicians and people with Long COVID gathered in Santa Barbara, California, in late March for a forum on advancing clinical care in infection-associated chronic conditions.

thesicktimes.org

💙 We have had a pretty intense #longcovidawarenessmonth so will be having a quiet few weeks to recoup If you missed our advocacy: 🎙️a super talk with @putrinolab.bsky.social on Medical Education 🎁 a gift of a medical binder to you 📣 podcast with @quietriotpod.bsky.social Catch up with links👇

What an incredible community! Thank you everyone for your interest in our trials for #LongCOVID, #MECFS and chronic #lyme. Our coordinators returned to work today with full inboxes from interest in our decentralized trials. So much gratitude for you all. Thank you! 🙏🏻

I don’t say this nearly enough on here, but I’m so grateful for my team. They’re some of the hardest working, brilliant folks on the planet. Whether they’re pushing the needle on first-in-human #BCI tech, helping folks with diagnoses like #LongCOVID, #MECFS and chronic #lyme 1/

New publication out now! 📣 Audiovisual entrainment therapy significantly improved chronic neuropathic pain in this double-blind, placebo-controlled RCT! Exciting to see that both pain AND pain medication use decreased in the active treatment arm. link.springer.com/article/10.1... 1/

Audio-visual stimulation therapy for chronic neuropathic pain: a sham-controlled randomized clinical trial - BMC Neurology

BMC Neurology - Neuropathic Pain (NP) affects 10% of the general population, decreasing quality of life for millions of Americans and contributing to higher physical and mental health care costs....

link.springer.com

Excited to finally get this one out in @Nature_NPJ! In the largest study of its kind to date, we used data from the @visible_health platform to answer a simple question: can we predict symptom fluctuations and crashes from both the physiological and www.nature.com/articles/s41... 1/

Digital physiological biomarkers predict within-person symptom changes in complex chronic illness - npj Digital Medicine

npj Digital Medicine - Digital physiological biomarkers predict within-person symptom changes in complex chronic illness

nature.com

Long Covid Advocacy @longcovidadvoc.com · 5mo ago

Excited to get this out in preprint: triple-blind, placebo-controlled microtesla magnetic therapy (MMT) is safe, feasible and effective in reducing cognitive impairment in people with #LongCOVID. I get excited about interventions for cognitive symptoms www.medrxiv.org/content/10.6... 1/

Microtesla Magnetic Therapy for cognitive impairment in post-acute sequelae of SARS CoV-2: A randomized controlled feasibility study

Background: Cognitive impairment has significant implications for function and quality of life and is common in individuals with post-acute sequelae of SARS CoV-2, also known as long COVID (LC). Emerg...

medrxiv.org

Link to our talk 'On Medical Education' with Prof David Putrino @putrinolab.bsky.social and some of the clips we shared on #LongCovidAwarenessDay #medsky bsky.app/profile/long...

Long Covid Advocacy (@longcovidadvoc.com)

Fantastic interview with Dr Rupert Higham from the Institute of Education at UCL and Prof David Putrino 'On Medical Education for Long Covid, ME and IACI' It is divided into short named chapters for…

bsky.app

Long Covid Advocacy @longcovidadvoc.com · 5mo ago

⚡️Right to Try⚡️ One key change @putrinolab.bsky.social would make if he had a magic wand would be prescribing freedom, especially in countries like the UK & Australia, for off-label meds. Full interview 'On Medical Education' 🖇️ 👇️ #LongCovidAwarenessDay

Proud to have worked with the brilliant @drmfreire on this new study looking into spike protein in #LongCOVID. The most important part of this study that doesn't just look for spike protein in folks with LC and healthy controls, but it also uses a technique called www.biorxiv.org/content/10.6... 1/

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies

SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains poorly defined. To address this critical gap, we employed a high-resolution, multi-modal approach—combining RNAscope, GeoMx Digital Spatial Profiling (DSP), spatial transcriptomics, and multiplex immunofluorescence—on 25 terminal ileum and left colon biopsies from a clinical cohort of 8 LC participants and 5 healthy controls. We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested. Yet, comparison of Spike-positive (Spike+) regions in LC versus healthy control colon tissues revealed a differential, symptomatic state-associated signature, with 57 differentially expressed genes (DEGs) (26 upregulated, 31 downregulated), revealing genes that disrupt the immune response in LC subjects. LC colon Spike+ regions demonstrated increased expression of AQP8 and other absorptive-related genes (SLC26A3, SLC26A2, and CLCA4) which are involved with Crohn′s disease along with transcripts involved in tumorigenesis (GUCA2A, S100P, TSPAN1). Simultaneous downregulation of key homeostatic chemokines (CXCL13, CCL19, CCL21), and other transcripts reported to exhibit low expression in colorectal cancers (TMEM88B, NIBAN3, DMBT1), suggesting a paradox of epithelial tissue stress yet dysfunctional immune trafficking. Further analysis comparing Spike+ versus Spike- regions within LC colon tissue demonstrated an active, localized, antigen-driven immune microenvironment, identifying 122 DEGs (82 upregulated, 40 downregulated), including tumorigenesis genes. Cellular deconvolution of Spike+ regions revealed a statistically significant focal enrichment of myeloid-derived cells (macrophages, non-classical/intermediate monocytes), plasma cells, and regulatory T cells, coupled with significant enrichment in T-cell-related pathways, including ″Antigen processing and presentation,″ and ″Th1/Th2/Th17 cell differentiation″. The ileum displayed a similar, though less pronounced, signature, demonstrating these statistically significant findings are specific to the colon of LC subjects. In contrast, corresponding Spike+ vs. Spike- analysis in healthy control colon tissues showed a more modest transcriptional response with 38 DEGs. Our data provide robust evidence that persistent SARS-CoV-2 Spike protein detection in the gut is not immunologically inert. Instead, it is actively associated with distinct, immune cell composition shifts and a dysfunctional pro-inflammatory transcriptional profile, supporting the hypothesis that retained viral antigen drives chronic immune dysregulation in tissue of Long COVID subjects. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org

Thanks to @emergeaustralia.bsky.social for bringing me on to discuss #longCOVID, #MECFS and other infection-associated chronic conditions and illnesses. A great conversation about the need for precision and personalized medicine to address these issues: emerge.org.au/podcast/epis...

Episode 46 – Professor David Putrino Returns – Emerge Australia

emerge.org.au

Fun to get to talk human performance and brain health in healthy adults over 50! Thanks to Inc for this great piece: www.inc.com/joseph-arang...

This 30-Day Neuroscience-Backed Plan Can Sharpen Your Brain—Especially If You’re Over 50

Improve focus, mood, and decision-making in just 30 days with science-backed habits for sleep, strength training, and metabolic health—especially for adults over 50.

inc.com