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Raiees Andrabi

@raieesandrabi.bsky.social

Associate Professor @PennMedicine @Penn Viruses| Vaccines| Protein engineering| B cells| Antibodies| Glycans. Cricket enthusiast https://www.med.upenn.edu/apps/faculty/index.php/g275/p9737250

10 Posts53 Follower100 Folgt
Raiees Andrabi@raieesandrabi.bsky.social · 5mo ago

Excited to share our new paper in @cp-immunity.bsky.social showing that "Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques" A promisingstep toward an HIV vaccine advancing soon to human clinical testing! Immunity www.cell.com/immunity/ful...

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques

Inducing broadly neutralizing antibodies (bnAbs) remains a challenge in HIV vaccine development. Mishra et al. show that an engineered germline-targeting HIV trimer, Q23-APEX-GT2, primes rare V2-apex ...

cell.com

Hensley Lab@scottehensley.bsky.social · 6mo ago

Our preprint examining the specificity of human antibodies that cross-react with subclade K H3N2 viruses was posted this morning on medRxiv. These studies have implications on what vaccine strains should be selected for next year’s influenza season. 1/ www.medrxiv.org/content/10.6...

Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine

An H3N2 variant, named subclade K, continues to circulate widely during the 2025-2026 influenza season. This virus possesses a hemagglutinin (HA) protein that has eleven substitutions relative to the ...

medrxiv.org

Bloom lab@jbloomlab.bsky.social · 6mo ago

We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.

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Raiees Andrabi@raieesandrabi.bsky.social · 7mo ago

Now peer-reviewed at @sciimmunology.bsky.social Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development | Science Immunology www.science.org/doi/10.1126/...

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development

B cell priming is a primary bottleneck to HIV-1 V2 apex bNAb elicitation.

science.org

Raiees Andrabi@raieesandrabi.bsky.social · last yr.

A fantastic collaborative effort with the BatistaLab (Ragon/Harvard), ShawLab(Penn) and IrvineLab (Scripps) where we show how targeted immunogen design can induce HIV broadly neutralizing antibody responses! www.biorxiv.org/content/10.1...

Raiees Andrabi@raieesandrabi.bsky.social · last yr.

In our new study, we show that several pre-Omicron RBD bnAbs still neutralize highly mutated SARS-CoV-2 variants. Structures reveal conserved, vaccine-targetable epitopes that resist extreme antigenic drift, highlighting promising targets for pan-sarbecovirus vaccines www.cell.com/cell-reports...

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

Identifying and understanding the molecular basis of conserved spike epitopes targeted by broadly neutralizing antibodies (bnAbs) are key for developing broad coronavirus vaccine design. Song et al. r...

cell.com

Raiees Andrabi@raieesandrabi.bsky.social · last yr.

A fantastic collaborative effort with the BatistaLab (Ragon/Harvard), ShawLab(Penn) and IrvineLab (Scripps) where we show how targeted immunogen design can induce HIV broadly neutralizing antibody responses! www.biorxiv.org/content/10.1...

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

Current vaccine strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multi-boost immunization regimens. In rhesus macaques, SHIV infection has been obs...

biorxiv.org