Ralph Emilio Peterson

@ralphpeterson.bsky.social

Neuroscientist & musician interested in sensory processing, natural neuroscience, biological/artificial collective intelligence. Northeastern -> Harvard -> NYU -> Basis Research Institute

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

A synaptic locus of song learning - Nature

Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...

nature.com

More control wires enable finer control. The Banerjee lab's findings on the neuroanatomical underpinnings of vocal dexterity neatly tie in with a recurring motif in brain evolution: pre-existing pathways can be selectively expanded to increase sensorimotor control and expand behavioral repertoires.

Cedric Boeckx@cedricboeckx.bsky.social · 3mo ago

“Specific expansion of motor cortical projections in a singing mouse” Great new work by @arkarupbanerjee.bsky.social E. Isco @cliffscience.bsky.social @xmikezheng20.bsky.social @tonyzador.bsky.social & colleagues on the neural basis of vocal dexterity, now out in @nature.com 🧪🧠

Where does learning through imitation happen in the brain? In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

A synaptic locus of song learning

Learning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)

biorxiv.org

As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out! This study sets the stage for understanding the origins of novel (vocal) behaviors. Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social

Cedric Boeckx@cedricboeckx.bsky.social · 9mo ago

Great @currentbiology.bsky.social study by @xmikezheng20.bsky.social @cliffscience.bsky.social @arkarupbanerjee.bsky.social 🧪🧠🐭🎶 Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node www.cell.com/current-biol...

🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo ago

Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice https://www.biorxiv.org/content/10.1101/2025.10.16.682851v1

A new preprint field study reveals that New York City’s rats aren’t just survivors—they’re talkative city dwellers with their own hidden nightlife. Mapping their movements and conversations could offer insights to transform urban planning and pest control

New York City’s Rats Have a Secret Nightlife—And a Language Humans Can’t Hear

A new preprint field study reveals that New York City’s rats aren’t just survivors—they’re talkative city dwellers with their own hidden nightlife. Mapping their movements and conversations could offe...

scientificamerican.com

The lab is growing! Our team is seeking talented scientists to study flexible sensory processing. We design freely-moving and head-fixed acoustic behaviors alongside acute and wireless neural recordings. PD and grad roles available Please help spread the word 🙏🧠🎵🐭 neurojobs.sfn.org/job/38911/po...

Postdoctoral Neuroscience Researcher - Storrs Mansfield, Connecticut job with Audette Lab, University of Connecticut | 38911

Fully funded postdoctoral research position studying context-dependent sensory processing in the mouse motor and auditory thalamus and cortex.

neurojobs.sfn.org

Ok, reinforcement learning fans: RL is great, but what do we do when there's no obvious reward from the environment? What about perfecting a golf swing or a foxtrot or a musical performance? We may have an answer. A tale of 🐦 🎶 + 🧠. 🧵1/ #bioacoustics #prattle 💬 #neuroai #compneuro

Ziyi Gong@gongziyida.bsky.social · last yr.

I am happy to share our new preprint! In this work, we proposed a theory about how zebra finches bootstrap their error signals for self-guided RL via predictive coding 👇 www.biorxiv.org/content/10.1...

Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...

Discovering cognitive strategies with tiny recurrent neural networks - Nature

Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...

doi.org

My latest Aronov lab paper is now published @Nature! When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️ The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar bit.ly/3HvWSum

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🦇👂🧠Our first bat paper is out! 🧠👂🦇 How do bats tell navigation from social calls? Led by the fearless Dr. Jenni Lawlor, we used 2P imaging to show that the auditory midbrain encodes categorical primitives. Check it out @natneuro.nature.com: rdcu.be/ehEgz

Spatially clustered neurons in the bat midbrain encode vocalization categories

Nature Neuroscience - Using two-photon imaging in awake bats, the authors show that the inferior colliculus encodes vocalization categories as categorical primitives—spatially clustered,...

rdcu.be

I highly recommend this inspiring new book by Nahum Ulanovsky! A plea for neuroscientists to embrace “Natural Neuroscience”: use emerging technologies to uncover meaningful behavior and neural representations in free-roaming animals exposed to real-world stimuli. mitpress.mit.edu/978026204499...

Natural Neuroscience

Natural neuroscience departs from the classical reductionist approach, which emphasizes control at the expense of natural behaviors, by proposing a shift tow...

mitpress.mit.edu