1/3 👉 Not every #photomanipulation experiment needs rapid beam positioning or simultaneous illumination of multiple areas. For many workflows, local light delivery in the center of the FOV is exactly what is needed.

1/3 💡 What if #photostimulation could match the 3D structure of your sample? Holo4D uses SLM-based holographic beam shaping to project defined light patterns onto selected cells or clusters, bridging #multiphoton imaging with targeted 3D stimulation.

1/2 🌡️ What if temperature control became your next #photomanipulation tool? Temperature plays a central role in biology. It can influence protein activity, molecular interactions, reaction rates, and cellular behavior. 🔍 Many questions need more precision than whole-sample heating can provide.

1/3 🤔 Did you know an existing Olympus BX51WI can be upgraded into a 2P microscope? ➡️ With @Sutter’s DF-Scope®, a familiar lab workhorse for electrophysiology, transmitted-light and epifluorescence workflows gains the key optics/electronics for #TwoPhotonMicroscopy.

1/3 🪄 Modern #microscopy is no longer only about observing samples. 🌀 With #FLUCS, a rapidly scanned IR laser creates controlled, localized thermoviscous flows inside the sample, turning the microscope into a tool for active, non-invasive flow perturbation.

1/3 🔬 Today is the final day of our in-person #LaserCaptureMicrodissection demo at @mpibiochem.bsky.social. Thank you to the Matthias Mann group and Martin Spitaler for the hospitality and support throughout the week.

1/3 🔬 Yesterday at @mpibiochem.bsky.social: two #AccuvaCellect talks and demo sessions. In the morning, we presented to the Matthias Mann group and connected #LCM to #DeepVisualProteomics: AI-based phenotype analysis, laser microdissection and ultrasensitive #MassSpectrometry.

1/2 🔬 Live demo next week: #AccuvaCellect at the @mpibiochem.bsky.social in Martinsried. We invite researchers to experience #LaserCaptureMicrodissection hands-on and discuss sample isolation workflows. 👏 A huge thank you to Martin Spitaler for his invaluable support in organizing the demo.

1/3 🧠⚡ First day at #FENS2026, and the atmosphere is already electric. The venue is buzzing with positive energy, and we’re excited to be in Barcelona with the #neuroscience community.

1/4 🧠 #FENS2026 is around the corner, and we’re excited to join the #neuroscience community in Barcelona. Ahead of the meeting, we’re highlighting one of our favorite platforms to customize: the Sutter Instrument Moveable Objective Microscope, or MOM.

1/2 🧠 Next stop: #FENS2026 in Barcelona. 📅 From July 6–10, we’ll join the #neuroscience community together with our long-standing partners Chroma Technology Corp. and TOPTICA Photonics. 😊 Come by and talk to @swarnck.bsky.social and @martinbrill.bsky.social.

1/2 ☀️ Conference season is in full swing. So, let's talk about what RAPP does. ➡️ Short answer: modular, customizable optical solutions for #microscopy, configured around your experimental setup and application. Here’s a quick-start guide to the RAPP portfolio before heading off to #FENS2026.

1/3 ✨ #ELMI2026 wrapped on Friday, and what a week in Coimbra. Old friends, new connections, great talks, and the open #ELMI atmosphere we love. 🙏 Huge thanks to our hosts & organizers from the @ppbioimaging.bsky.social and to the @eulimi.bsky.social community for a beautifully run meeting.

1/3 ✨ Closing day of #ELMI2026 in Coimbra. Time flies when it’s this much fun: microscopy, great conversations, old friends, new connections, coffee breaks, and the open ELMI atmosphere we love. 📸 As a small thank you, here are some of our favorite impressions over the past few days.

1/2 ✨ Day 1 at #ELMI2026 is in full swing, and booth no. 10 is already *the* place to be. 🤝 We’re sharing the booth with our good friends Almut Bailly and Zain Ali from Chroma Technology Corp. and Helge Schmidt from TOPTICA Photonics.

🔬 The #EMBO | #EMBL Symposium "Mechanobiology across the tree of life" is well underway here in Heidelberg. 💡 Come by our booth to talk about #photomanipulation, laser ablation, #FLUCS, and custom microscopy solutions for #mechanobiology experiments. 👋 See you at the booth! #EESMechanobiology

☀️ June is here, and conference season is in full swing. We are excited to be joining the #EESMechanobiology in #EMBLHeidelberg and connecting with the #mechanobiology community. 👏 Thank you to the scientific organizers, @embo.org, @embl.org, and @events.embl.org for bringing this symposium together.

1/2 ✨ We are truly delighted to be a Gold Sponsor of #ELMI2026. 🤝 We are also especially pleased to share a booth with our good friends from Chroma Technology Corp. and TOPTICA Photonics as we rely on strong collaborations and trusted, long-term partnerships.

🎉 Congratulations to all authors on this brilliant paper and the well-deserved JCB cover feature! 👏 A beautiful study connecting cortical cytoskeleton organization, cell shape, signaling, and epidermal differentiation. We are truly excited to see our technology contribute to this outstanding work.

Rockefeller University Press@rupress.org · 4mo ago

@jcb.org's April issue is here! rupress.org/jcb/issue/22... Image shows immunofluorescence whole-mount staining of cortical F-#actin networks with phalloidin in alI-#spectrin deficient newborn mouse #epidermis. From Soffer, Bhosale et al. rupress.org/jcb/article/...

1/3 How does the cortical #cytoskeleton connect cell shape w/ cell fate? A recent @jcb.org @rupress.org paper by Soffer et al. uses the #epidermis to study how shape transitions are coordinated w/ differentiation. The study identifies #spectrin as an essential organizer of the #actomyosin cortex.

1/2 🧬 For #DNArepair studies, chemically-induced damage is often too blunt. 🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging. #Microscopy #Bioimaging

1/4 🔬 In many tissue samples, the region of interest is surrounded by material you do *not* want in your downstream analysis. #LCM helps isolate selected cells or tissue regions with higher specificity before DNA, RNA, or protein analysis. #Microscopy #Bioimaging #LaserCaptureMicrodissection

1/4 🌱 Biologists spend enormous effort keeping their favorite organisms happy. But to understand biology, one often needs to perturb it. 🎯 Precisely. 💡 That is where #photomanipulation comes in: focused light used to locally modify, stimulate, cut, or disrupt processes in a sample.

1/3 😬Every live-cell microscopist knows the feeling: the fluorescence signal looked perfect when the experiment started. 🔬In #FluorescenceMicroscopy, prolonged/intense excitation can permanently destroy fluorophores. ❌For #LiveCellImaging, that means fine details becoming harder to resolve.

1/2 🇩🇪 We are pleased to support the EMBL @events.embl.org Course “Advanced Fluorescence Imaging Techniques” in Heidelberg together with #Evident Microscopy. ✨ Anja Zimmermann will contribute to the course with a talk and hands-on workshops on RAPP #photomanipulation systems. #EMBLFluorImaging

1/3 🪄 What if you could move intracellular structures using only light? 🌀 FLUCS uses a rapidly scanned IR laser to generate thermoviscous flows inside the sample. ❌ No contact ❌ No labels ❌ No RI matching required ✅ Just your sample & IR light #Photomanipulation #Microscopy #Bioimaging #Biophysics

1/3 💡 What makes the @sutterinstrument.bsky.social MOM® stand out? It is built around a simple idea: move the objective, not the specimen. Its open, robust design makes it a flexible platform built to serve evolving workflows for years to come. #Microscopy #Bioimaging

1/3 💡 What makes the @sutterinstrument.bsky.social MOM® stand out? It is built around a simple idea: move the objective, not the specimen. Its open, robust design makes it a flexible platform built to serve evolving workflows for years to come. #Microscopy #Bioimaging

1/3 🫀 Atherosclerotic lesions are #plaque buildups in the arterial wall that reduce blood flow. Foam cells, i.e., lipid-laden macrophages, are central to plaque progression. 💔 As lesions advance, the outcome can be severe: thrombosis, heart attack, or stroke. #LaserCaptureMicrodissection

1/2 ✨Mark and track only the molecules you choose. 🔦 #Photoactivation: Signal appears only after local illumination. 🎨 #Photoconversion: Contextual tracking, where you can mark a selected population but observe both the converted and unconverted populations. ➡️The real power of both? Spatial control.