Our RNA-linked CRISPR approach is now published! Work led by fantastic graduate student in the lab, Patrick Nugent.

Nature Methods@natmethods.nature.com · last yr.

ReLiC is an RNA-linked CRISPR platform for dissecting RNA metabolic processes, revealing key regulators of RNA splicing, translation and decay. @rasilab.bsky.social www.nature.com/articles/s41...

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social! We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo. www.biorxiv.org/content/10.1...

Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions

Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...

biorxiv.org