New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪 www.ahajournals.org/doi/10.1161/...

Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help. www.frontiersin.org/journals/nut...

Frontiers | Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction

Trehalose is a naturally occurring disaccharide with versatile commercial applications and health benefits, including promise as a therapeutic for obesity an...

frontiersin.org

Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!

Spilling the skinny on fat cells! @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO

Spilling the skinny on fat cells! ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR

Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey. www.cell.com/immunity/abs...

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controllin...

cell.com

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL) jci.org/articles/view/185340

Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩

Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪 www.unitedformedicalresearch.org/annual-econo...

Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next! www.nature.com/articles/s41...

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

nature.com

Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University. www.nature.com/articles/s43...

Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target - Nature Aging

Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse mod...

nature.com

Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!