Ever wondered about the difference between an asymmetric unit and a biological assembly? Watch this office hour to learn more and to see how to access these data from RCSB PDB

Exploring Biological Assemblies in the PDB

When exploring Structure Summary pages, you will notice images and coordinate files for the "Biological Assembly" and the "Asymmetric Unit". In many PDB entries, these are the same. However, for some entries (mostly those solved by X-ray crystallography), you may notice a difference between the asym

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Meet wwPDB members at IUCr in Calgary, Canada from August 11-18. Only a few slots left for the wwPDB workshops at #IUCr2026! Join us in Calgary to learn how to deposit with OneDep and/or PDB-IHM in FREE pre-conference events

wwPDB Events at IUCr

Meet team members from around the globe at the International Union of Crystallography meeting in Calgary

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Histone Ubiquitination and Deubiquitination Complexes Enzymes that add and remove marks from chromosomes to keep gene regulation in balance August's Molecule of the Month at PDB-101:

PDB101: Molecule of the Month: Histone Ubiquitination and Deubiquitination Complexes

Enzymes that add and remove marks from chromosomes to keep gene regulation in balance

pdb101.rcsb.org

Bacteriophages, viruses that infect bacteria, coexist in an evolutionary arms race with their bacterial hosts on Earth. But what happens when that arms race moves into orbit?

In orbit, viruses evolve new ways to kill bacteria

Researchers at the University of Wisconsin publish findings from studies on the International Space Station, showing how space accelerates the evolution of viruses that infect bacteria.

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The first high-resolution structural images of human Argonaute 2 in its cutting-ready state reveal why some small interfering RNA (siRNA) molecules work better than others and how to design more effective ones for this emerging therapy.

Molecular scissors caught in action: A structural blueprint for RNA therapeutics - Scripps Research

A Scripps Research team has captured the first high-resolution structural images of human Argonaute 2 in its cutting-ready state, revealing why some small interfering RNA (siRNA) molecules work better than others and how to design more effective ones for this emerging therapy.

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Celebrate #RNADay on AUG 1 with a variety of PDB-101 resources pdb101.rcsb.org/motm... pdb101.rcsb.org/brow...

Celebrate #ColoringBookDay on August 2 at PDB-101 with the "Discovering Biology Through Crystallography" Coloring Book pdb101.rcsb.org/lear...

wwPDB News: The refactored “Based on previous” workflow allows depositors to selectively import and reuse mmCIF metadata from a previously deposited PDB entry with method-aware safeguards, macromolecule checks, ORCID search, and transparent import logging.

Reuse Metadata from Previous PDB Depositions

The refactored “Based on previous” workflow allows depositors to selectively import and reuse mmCIF metadata from a previously deposited PDB entry with method-aware safeguards, macromolecule checks, ORCID search, and transparent import logging.

rcsb.org

Watch the Webinar: Exploring Integrative Structures with RCSB PDB Learn how to explore PDB structures determined using integrative and hybrid methods with RCSB PDB tools

PDB101: Exploring Integrative Structures with RCSB.org

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

Events at Microscopy & Microanalysis Join wwPDB members for presentations on the preservation and validation of electron microscopy data at the M&M meeting in Milwaukee, WI. www.rcsb.org/news/6a...

"FAIR + COPE (Comparable, Organized, Predictive, Engaged) takes FAIR data and makes it Comparable, rapidly Organized (applying / updating standards) for Predictive models, which can be validated and improved by an Engaged community."

Advancing FAIR data towards comparable, organized, predictive AI-ready data for community validation

Communications Biology - This Perspective explores how updating static, FAIR data/databases can lead to COPE: Comparable, Organized (AI-ready) data that supports novel Predictions of biological...

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Download the PDB-101 poster that displays 200 icosahedral viruses using a color scheme that indicates the number of protein chains in each capsid

PDB101: Learn: Flyers, Posters, & Calendars: Posters: 200 Icosahedral Viruses

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

A Nobel laureate’s decades-long commitment to open science is reshaping biotechnology in the AI era

Protein Design’s AI Revolution: Inside David Baker’s “Communal Brain”

A Nobel laureate’s decades-long commitment to open science is reshaping biotechnology in the AI era.

genengnews.com

The amoeba Dictyostelium discoideum, commonly known as slime mold, is a useful model organism because of its structural similarities to mammalian cells and its shared conserved intracellular signaling pathways

New method visualizes slime mold protein assemblies

Researchers at the University of Texas characterize several high molecular weight protein assemblies of slime mold and solved the structure of a primary fatty acid synthase.

asbmb.org

Lawnmower-like Enzyme Rewinds Decades of Molecular Aging in Human Tissue An engineered enzyme cleaved and repaired age-related protein damage in human tissue, which was long thought to be irreversible in a proof-of-concept study www.the-scientist.co...

PDB-101 #biotechnology materials explore how researchers are using biology in industry, including how biological evolution is being harnessed in the lab to create new enzymes

PDB101: Molecule of the Month: Directed Evolution of Enzymes

Biological evolution is being harnessed in the lab to create new enzymes.

pdb101.rcsb.org

To infect a cell, hantavirus surface spikes bind to proteins on the surface of target cells, including cells that line blood vessels and the respiratory tract. More at PDB-101: pdb101.rcsb.org/motm...

Only a few slots left for the wwPDB workshops at #IUCr2027 ! Join us in Calgary to learn how to deposit with OneDep and/or PDB-IHM in FREE pre-conference events IUCr2026 www.wwpdb.org/news/n...

One more reason to love the @rcsbpdb.bsky.social? A hidden gem in the PDB: The 3D Sequence Annotation Viewer! youtu.be/6zKBBkzl-4A

PDB 3D Sequence Annotation Viewer for exploring features of protein etc. structures, examples

YouTube video by the bumbling biochemist

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Big PDB Changes Are One Year Away! On July 21, 2027, wwPDB will fully transition to extended PDB IDs for new depositions and the PDB archive will use a new directory structure based on 12-character extended PDB IDs. Visit wwpdb.org for details.

DNA and RNA store and deploy genetic information. PDB structures reveal how some nucleic acids also fold to form complex molecular machines. Guided by these structures, nanotech scientists are building new machines composed of nucleic acid. #DDNASRC

PDB101: Browse: Nucleic Acids

PDB-101: Training, Outreach, and Education portal of RCSB PDB

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Meet RCSB PDB at #TheProteinSociety Catch up on recent developments in the poster session on Tues July 21, and join us in celebrating new Protein Society Fellows Stephen Burley and Helen Berman #PS40

Meet RCSB PDB at The Protein Society

Catch up on recent developments in the poster session, and join us in celebrating new Protein Society Fellows Stephen Burley and Helen Berman.

rcsb.org

Scripps Research scientists developed a vaccine that teaches the immune system to rapidly neutralize fentanyl and new emerging synthetic fentanyl analogs. www.scripps.edu/news...

On the cover of Cell Genomics: The image depicts a nerine flower and the spatial structure of the VDAC protein, which the program NERINE links with Parkinson's disease. Artist: Rauf Sunyaev. www.cell.com/xgen/is...

CellWalk is a biology textbook come to life. The incredible visionOS app offers people a window into biology, a chance to examine and explore vibrant 3D models of cellular structures.

CellWalk: The beauty of biology on visionOS - Discover - Apple Developer

Created for students and casual science lovers alike, the 2025 Apple Design Award finalist provides up-close images of life’s molecular masterworks, which are rendered in full color and accompanied by easy-to-understand explanations.

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Summer Newsletter: Extended PDB IDs; updates to predicted CSMs at RCSB PDB; exploring protein domains at PDB-101; and more In the Education Corner, learn about Solving Structures, Enabling Discovery: The Impact of the CRSTAL-ID Centers

RCSB PDB Quartely Newsletter | Summer 26 | Issue 110

This issue highlights Extended PDB IDs; updates to predicted Computer Structure Models at RCSB.org, and PDB-101 resources for exploring protein domains

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Every second inside every living cell, thousands of chemical reactions are taking place that constitute the essential tasks of life such as metabolism, protein synthesis, cell renewal and growth. Learn how enzymes work in this PDB-101 video

How Enzymes Work (from PDB-101)

Every second inside every living cell, thousands of chemical reactions are taking place. These reactions constitute the essential tasks of life such as metabolism, protein synthesis, cell renewal and growth. Learn how the proteins called enzymes work to maintain the rate of these reactions at a life

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Exploring the Structural Biology of Bioenergy Cells capture and utilize many forms of energy to power their molecular processes More at PDB-101:

PDB101: Learn: Exploring the Structural Biology of Bioenergy

Cells capture and utilize many forms of energy to power their molecular processes

pdb101.rcsb.org

#IUCr2026 Dorm & hotel Booking Deadline Extended to July 14! And registration comes with a free transit (C-Train) pass. See you in Calgary, crystallographic cowboys...

IUCr2026 @iucr2026.bsky.social · last mo.

🚨 Final reminder: #IUCr2026 hotel blocks close today. 🏨 Discounted Congress rates expire at the close of business and availability after today cannot be guaranteed. 🔗 Book now: event.fourwaves.com/... #IUCr2026 #IUCr #Crystallography

Are you going to IUCr26? Find out more about our friends at the Early Career Science Division (ECSD) who represent early career scientists within the IUCr (They're basically our cooler, international cousins) 💻 More info on: www.iucr2026.org See you in Canada! ⛰️ @iucr2026.bsky.social