Release News: V97 of Reactome is live! 🎉 We have new and updated topics and pathways. Read more here: reactome.org/about/news/2...

Check out our Reactome Research spotlight! A 2026 Nature Genetics study found 13 genetic loci linked to susceptibility to SARS-CoV-2 Omicron infection. Reactome analysis showed these genes are enriched in glycosylation pathways, pointing to host glycan biology as a key factor in viral infectivity

Check out our selection for our latest #ReactomeResearchSpotlight! 💡 In their March 2026 Society of Toxicology paper, “A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets”. 🖥️🧬

Release News: V96 of #Reactome is live! 🎉 We have new and updated topics and pathways in Developmental biology, Disease, Immune system, Metabolism, Muscle Contraction, and more. 💡 Read more about V96 here :https://reactome.org/about/news/291-v96-released

Check out our selection for our latest #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight! 🖥️🧬

Preprint alert! 🚨 We’ve released two new Reactome preprints. Together, these studies show how AI can scale curation and improve accessibility without compromising accuracy or biological rigor. Learn more here: reactome.org/about/news/2... 🖥️🧬

Check out our selection for our first 2026 #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight! 🖥️🧬

Release News: V95 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.

New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬

The Reactome Knowledgebase 2026

Abstract. The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes huma

doi.org

Advances like this underline how much early detection and mechanistic clarity matter in rare metabolic disease. For those examining the underlying biology of Hunter syndrome, Reactome’s pathway (reactome.org/content/deta...) provides a clear view of the disrupted iduronate-2-sulfatase process.

LifeArc@lifearc.bsky.social · 9mo ago

We are co-funding a new clinical trial to investigate if a one-off gene therapy to replace faulty genes in stem cells can bring hope to children with Hunter syndrome. Ollie is the first child to participate in this @manchester.ac.uk study: bit.ly/49BaCjt

This week marks World Antimicrobial Resistance (AMR) Awareness Week. In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here: reactome.org/PathwayBrows...

Check out our selection for October's #ReactomeResearchSpotlight! Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response" Read more: 🔗 reactome.org/content/reac... 🖥️🧬

See you all next week!

Reactome@reactome.org · last yr.

Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.

🚨 New Beta Release: Reactome Pathway Browser Explore biology with a modernized interface: 🔗 reactome.org/beta/Pathway... Feedback welcome → forms.gle/TPBxaWnnVLLZ... 🖥️🧬

🎉 We just launched the Reactome Figma Library! You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0. www.figma.com/community/fi... Demo video: youtu.be/xl2LfczKhGY 🖥️🧬

Reactome Icon Library | Figma

A curated set of biological icons designed to support scientists and designers in creating clear, consistent figures and posters. Includes pathway components such as proteins, complexes, reactions, an...

figma.com

Release News: V94 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules 🖥️🧬

Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...

Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.

Starting the new academic year with a Reactome Research Spotlight🖥️🧬 In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...

Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.

Release News: V93 of #Reactome is live! 🎉 We have new and updated topics and pathways. 💡 Read more about V93 here: reactome.org/about/news/2...

Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...

Reactome is now CoreTrustSeal certified, meaning that our pathway data meets global standards for transparency, accessibility & long-term stability. Learn more at reactome.org/about/news/2... A big win for #FAIRdata, open science, and everyone who relies on Reactome for biological knowledge. 🖥️🧬

Check out this recap, where our #Reactome Outreach Coordinator summarizes some of the team discussions we had at #ReactomeSAB 2025! 🖥️🧬

@thenancyli.bsky.social · last yr.

Let's recap last weeks #ReactomeSAB 2025 (scientific advisory board) meeting! This year, our international #Reactome team was hosted by the OICR in Toronto, where we had the opportunity to tell our external advisors about our work and gather feedback.

Check out our new Youtube video about contributing to Reactome! Learn more by watching our youtube video, created by Cristoffer Sevilla! www.youtube.com/watch?v=P5Gi... Like and subscribe to our Youtube channel for more updates! 🖥️🧬

Contributing to Reactome

YouTube video by Reactome Knowledgebase

youtube.com

Reactome Release News: V92 of #Reactome is live! 🎉 We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/2... 🖥️🧬

Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪

Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪

Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: reactome.org/content/reac... If you have a publication that leverages Reactome, please submit them to help@reactome.org!

The #ReactomeResearchSpotlight for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids 🖥️🧬